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Direct and indirect medical costs of bladder cancer in Iran

Cost Effectiveness and Resource Allocation volume 21, Article number: 5 (2023) Cite this article

Abstract

Background

Bladder cancer is one of the most prevalent and costly cancers in the world. Estimating the economic burden of bladder cancer is essential for allocating resources to different sectors of health systems and determining the appropriate payment mechanisms. The present study aimed at estimating the economic burden of bladder cancer in Iran.

Methods

In this study, we used a prevalence-based approach for estimating the economic burden of bladder cancer. Direct and indirect costs of bladder cancer were calculated using the cost of illness and human capital approaches. Data were collected using a researcher-made checklist obtained from several sources including Iran bladder cancer clinical practice guideline, the Statistical Center of Iran, Iran’s Ministry of Cooperatives, Labor, and Social Welfare, Relative Value of Health Services (RVHS) book and Iranian Food and Drug Administration organization.

The analyses were done by Microsoft Excel 2013 and Stata 13.

Results

The number of the cases of 5-year prevalence of bladder cancer in Iran was estimated as 21,807 people in 2018. The economic burden of bladder cancer in Iran was estimated at US$ 86,695,474. Indirect medical costs constituted about two-third of the economic burden of bladder cancer, and mostly related to productivity loss due to mortality. Most of the direct medical costs (29.7%) were related to the stage T2–T3 and transurethral resection of bladder (31.01%) and radical cystectomy (19.99%) procedures.

Conclusion

Our results showed that the costs of bladder cancer, imposed on the healthcare system, were significant and mostly related to lost production costs. The implementation of screening and diagnostic programs can improve the survival rate and quality of life of patients and reduce the cost of lost productivity due to mortality in these patients.

Background

Bladder cancer is one of the most prevalent cancers in both genders across the world and in males it is more than three times higher than females [1].

Urinary bladder cancer (UBC) clinically is classified to non-muscle invasive bladder cancer (NMIBC) and muscle invasive bladder cancer (MIBC) [2]. In Iran, NMIBC constitutes 68% of the bladder cancer diagnosed cases [3]. NMIBC which are restricted to the urothelial cell layers (stage Ta or Tis) or only penetrate the lamina propria (stage T1). At one end of the spectrum, low-grade NMIBC rarely progress to aggressive or metastatic tumors but as many as half will recur [4, 5]. At the other extreme, high-grade NMIBC have a high malignant potential associated with significant progression [6].

Bladder cancer is usually diagnosed at an early stage, however high progression and recurrence rate of this cancer results to a high economic burden [7]. The relative 5-year survival rate of UBC is about 97% (stage I) to 22% (stage IV) [2]. Bladder cancer is one of the most costly cancers in western countries [8] and also America [9]. Bladder cancer has the highest treatment cost per patient (from the time of diagnosis until death) [7].

Due to increasing trend of bladder cancer incidence in developing countries, we expect an increase in the economic burden of this cancer in the near future [10]. So, it is important to calculate the economic burden of cancers to provide the policy makers the awareness in allocating the resources to different sectors of health systems, also, insurance departments to determine the ways of paying the service healthcare providers [11,12,13]. Furthermore, such studies are used as a model of evaluating different therapeutic interventions, and they can be used as a basis for determining the priorities of medical studies [14, 15].

In a study in Iran on cancer patients, although patients with Urinary system accounted for only 2% of cases, they included 6.5% of the cancer costs [16]. Another study in Iran showed that breast, lung, blood and female reproductive organs cancers were the most costly cancers in Iran [17].

To our knowledge there is no evidence about the economic burden of bladder cancer in Iran and developing countries. We aimed to estimate the economic burden of bladder cancer in Iran for planning and policy making goals.

Methods

In this study we used 5-year bladder cancer prevalence by stage calculated in our previous study (refrence3). In the mentioned study, we used a prevalence-based approach to calculate the economic burden of bladder cancer in Iran for 2018 by a Markov model. More details of the Markov model and estimating procedure are presented elsewhere [3]. The we estimated both direct and indirect costs of bladder cancer as follows [3]:


(1) Direct medical costs estimation


To estimate the total direct medical costs of bladder cancer in Iran in 2018, we multiplied stage specific prevalent number of cases by the average cost per patient. We estimated the average costs per patient multiplying the frequency of health care services use per patients by the average price of the services. Health care services included diagnostic and treatment procedures and to identify the number of each services used per patient, we used Iran bladder cancer clinical practice guideline. The mentioned clinical practice guideline has been developed by cooperation of many research institutes and urology groups all over the country and published by the Ministry of Health, Treatment, and Medical Education of Iran [18]. The diagnostic and treatment services of bladder cancer by stage of the disease are depicted in Fig. 1.

Fig. 1
figure 1

Summary of the process of diagnosis, treatment and follow-up of bladder cancer

Full size image

We estimated the inpatient services average costs using our previous study results in 2015 [19] and updating the results for 2018 based on inflation rate of medical services in Iran. We used the Relative Value of Health Services (RVHS) book and medical tariffs approved by the government of Iran in 2018 [20] for the price of outpatient services including specialist visits, diagnostic tests, imaging, and etc. To extract the price of drugs we used the Iranian Food and Drug Administration organization data [21].


(2) Indirect costs estimation


Indirect costs of bladder cancer included both the morbidity and mortality cost due to bladder cancer. In this study, we used the human capital approach for estimating indirect costs [22] of bladder cancer in Iran. In this approach, we supposed the value of the lost production equal to the person’s income or wage.


Estimation of the morbidity cost


To estimate the Morbidity costs, we calculated the productivity loss due to bladder cancer incidence. Sometimes, patients affected by bladder cancer have to stop their daily activity for receiving healthcare. Furthermore, patient affected by high-grade cancer usually are not able to work anymore for the rest of their lifetime. This results in economic losses for both patients and the society. To estimate the productivity loss due to bladder cancer incidence, we used age-sex specific prevalent number of cases for the year 2018 in Iran multiplied by the number of daily work absence, age-sex specific employment rates, and the average daily wage.

We assumed the number of daily work absence equal to hospitalization days and the number of outpatient visit days. We extracted the average number of hospitalization days using previous studies [19] and the average number of outpatients’ visits using the bladder cancer Iranian clinical practice guidelines. We estimated all of the mentioned statistics by stage and elapsed time from diagnosis. We considered muscle invasive bladder cancer cases (local invasion and metastasis) as totally disabled [23].

We derived Age-Sex specific employment rates from Statistical Center of Iran data [24] and considered employee’s average annual income in Iran for the year 2018 as 8565 $, Based on household income and expense survey, and the Ministry of Labor and Social Affairs data [25]. we assumed the annual productivity loss value for housewives equal to the minimum annual wage in 2018 determined by the Ministry of Labor and Social Affairs (363,857,870.01 IRR). We calculated the average daily wage dividing the employees’ average annual income by the number of workdays in 2018 (290 days).


Estimation of the mortality cost


To estimate the mortality cost due to bladder cancer we calculated productivity loss due to premature death. To evaluate productivity loss due to bladder cancer morality in Iran for the year 2018, we multiplied the number of potential lost years by the age-sex specific employment rates, and the average annual income.

We calculated the number of potential lost years by subtracting the sex-specific age of death from the sex-specific life expectancy multiplied by the age-sex number of bladder cancer death. We estimated the age-sex number of bladder cancer death based on the results of the developed Markov model [3] and the Globocan 2018 data [26]. Calculating productivity loss cost we considered a 3% annual discount rate [27].

Statistical analyses

We calculated the economic burden of bladder by the sum of direct and indirect medical costs of bladder cancer. To estimate the total direct medical costs of bladder cancer, we estimated the average costs per patient multiplying the frequency of health care services use per patients by the average price of the services. To estimate the Morbidity and mortality costs, we calculated the productivity loss due to bladder cancer incidence and premature death. In this study, we did the analyses by Microsoft Excel 2013 and Stata, version 13 (Stata Corp, College Station, Texas). All cost were converted to US dollar by using the average exchange rate in 2018 (USD = IR Rials 40,864) [28].

Results

The total direct medical costs were equal to $28,657,910. The highest percentage of the costs (29.7%) was related to T2–T3 stage and the lowest one belongs to Carcinoma in situ (7.4%; Table 1). The costs of low-grade and high-grade Ta respectively constituted 18.7 and 12.8 percent of the total direct costs.

Table 1 The number of patients and direct medical costs of bladder cancer by stage in Iran in 2018
Full size table

Among diagnostic and treatment procedures administered for bladder cancer cases, TURBT and radical cystectomy accounts for the highest proportion of costs which constituted about 50% of the costs direct medical costs. Imaging and BCG therapy costs were the next ones (Table 2).

Table 2 Direct medical costs of bladder cancer in terms of diagnostic and treatment procedures in Iran (2018)
Full size table

The total number of lost workdays due to bladder cancer morbidity in 2018 was equal to 1,681,931 days. About 83% of the workdays were lost by male employees. The lowest and the highest number of lost workdays were respectively related to the age groups of 40–44 (2.4%) and above 75 years (24.1%). The total cost morbidity productivity loss due to bladder cancer was equal 17,599,403 $ in Iran for the year 2018; about 96% of this value was related to men. Although the highest number of the lost workdays was related to the age group above 75 years, the cost of productivity loss was zero as a result of the zero employment rates in this group. The highest cost of morbidity productivity loss due to bladder cancer was related to the age group of 60–64 years (21.5% of the total morbidity cost; Table 3).

Table 3 The number of lost workdays and morbidity cost due to bladder cancer in Iran (2018)
Full size table

In 2018, 2383 cases of death due to bladder cancer have been estimated in Iran. The lowest and the highest number of deaths were respectively reported for the age groups of 40–44 years (28 cases) and above 75 years (1202 cases). The cost of productivity loss due to bladder cancer mortality was estimated 40,438,160.73 $. The highest percent of this cost were respectively related to the age groups of 50–54 years (19.5%) and 55–59 years (19.4%) (Table 4).

Table 4 The number of premature deaths and mortality cost due to bladder cancer in Iran (2018)
Full size table

The total economic burden of bladder cancer in Iran for the year 2018 was estimated $86,695,473.86. Mortality cost due to bladder cancer was responsible for the majority part of economic burden of bladder cancer (46.6%) and only 33% of the economic burden of bladder cancer was related to direct medical costs (Table 5).

Table 5 Direct and indirect medical cost of bladder cancer in Iran (2018)
Full size table

Discussion

In this study, economic burden of bladder cancer in Iran (2018) was estimated US$86,695,474 based on prevalence based approach. Indirect medical cost was responsible for about 67% of the total economic burden of bladder cancer and cost due to mortality constitutes about two third of it. Among direct medical costs, T2–T3 stage had the highest proportion (About 30%) and the CIS stage had the lowest cost (7.4%). Transurethral resection of bladder tumor (TURBT) was responsible for one third of direct medical cost of bladder cancer. Males between the ages 50–64 were responsible for the majority cost of bladder cancer.

The Average direct medical costs of bladder cancer in Iran in 2018 were $1314 per prevalent case. In European Union, the annual health care expenditures due to bladder cancer accounted €6942 per prevalent case [8]. In the United States, inpatient and outpatient costs of bladder cancer were estimated at about US$7806 per prevalent case in 2010 [29]. As a result, some researchers have questioned the effectiveness of higher US spending and suggested it is driven by higher costs, unnecessary testing, and unproven medical procedures [30]. Differences in health care expenditures due to bladder cancer could be explained by health system configuration (eg, the number of hospitalization days due to bladder cancer, differences in the introduction and administration of new drugs, differences in the prices paid for the same drugs, differences in the types of medication consumed, and variations in clinical practice).

According to the stages of the disease, 56.7% of the costs were related to NMIBC and the remaining to MIBC. This finding is inconsistent with the results of the studies in America [31,32,33]. The findings of the study by Cooksley et al. suggested that the annual treatment cost for patients with muscle invasive bladder cancer was 70% more than the treatment cost of patients with non-muscle invasive bladder cancer [32]. In another study conducted by Avritscher et al. in America, the average cost primary treatment of bladder cancer was $6548 in non-muscle invasive stage and $42,035 in muscle invasive stage [31]. Considerable variation in the management of bladder cancer by different providers may contribute to heterogeneity of spending patterns. A variety of treatment algorithms are available for NMIBC management, and providers exert their best clinical judgment when choosing how strictly to adhere to these strategies.

In addition, the difference in results can be related to the prevalence in different countries. Regarding the higher prevalence of NMIBC than MIBC and high recurrence and progression rate is in this group that requires long term cystoscopy control and repeated interventions, the costs of NMIBC are considered higher than MIBC [2]. Furthermore, studies have shown that the care of patients with NMIBC varies significantly depending on the geographic region [34] and physician [35]. Also, the costs of caring for patients vary depending on the stages of disease; so that, these costs will increase by almost two times in the first 2 years after diagnosis [34].

According to our estimation of direct medical costs, the highest cost was related to TURBT and radical cystectomy. TURBT is the initial treatment of non-muscle invasive bladder cancer and it constitutes a major part of the total treatment costs [2]. The average cost of TURBT (including the costs of surgeon, anesthesia, operating room, hospitalization and laboratory tests) in Iran was US$1471 in 2018. The average cost of this procedure has been reported as US$4349 in America and US$2000–2500 in European countries [2].

Bacillus Calmette-Guerin (BCG) is suggested for patients with bladder cancer in CIS stage, high-grade Ta, and T1 [35,36,37,38]. According to the Iranian clinical practice guideline of bladder cancer, a 6-week period of induction therapy by BCG is suggested for patients in CIS stage, high-grade Ta, and T1 accompanying by maintenance intravesical treatment by BCG [35]. The average cost of a 6-week period of BCG injection (including the costs of the medicine and injection) in Iran (2018) has been estimated as US$4,409,786.19. The results of economic assessments suggested the intravesical immunotherapy by BCG to be cost-effective and its cost for one life-year saved is estimated to be about US$5000 [39,40,41].

Intravesical therapy is another treatment of bladder cancer NMIBC cases that includes immunotherapy and chemotherapy. Currently, clinical practice guidelines suggest intravesical chemotherapy to be performed immediately after TURBT for new diagnosed or recurred low-grade non-muscle invasive bladder cancer patients. Intravesical chemotherapy is usually done by using a dosage of mitomycin C 24 h after TURBT surgery [35,36,37]. The average cost of intravesical injection of a dosage of mitomycin C (40 mg) in Iran (2018) has been estimated US$45.4. The equivalent costs of this injection in America and England have been respectively estimated as US$219 and US$87 [2]. Although clinical practice guidelines suggest intravesical chemotherapy and economic studies have approved the cost-effectiveness of this treatment, it is not widely used even in America [42, 43].

In muscle invasive bladder cancer, based on the progress of disease and the patient’s conditions, a combination of treatments including TURBT surgery, radical cystectomy, neo-adjuvant chemotherapy, radiotherapy, and chemotherapy may be used for patients. According to suggestions of clinical practice guideline, the standard treatment of local muscle invasive bladder cancer (T2 or T3) is radical cystectomy accompanied by neo-adjuvant chemotherapy. Also, chemotherapy with or without radiotherapy has been suggested for patients with metastatic bladder cancer [35,36,37]. According to the data collected in this study, the average cost of cystectomy was US$948 in 2018. The costs of radical cystectomy in America and England were respectively equal to US$ 23,451 and US$ 8,090 [2]. The most prevalent bladder cancer chemotherapy drugs include Dose-Dense MVAC (methotrexate, vinblastine, doxorubicin, and cisplatin) and Gemcitabine and Cisplatin (GC) [2, 36]. As there is a significant difference between the prices of generic drugs and brand drugs, the costs of these chemotherapy drugs depend on using generic or brand drugs.

According to the findings of this study about 67% of the economic burden of bladder cancer in Iran results from the productivity loss cost. In a study conducted by Leal et al. aimed at estimating the economic burden of bladder cancer in European countries (2012), the total economic burden of bladder cancer in European countries was 4.9 billion Euros; 41% of this rate resulted from the lost production costs [8]. In a study conducted by Gerace et al. in Italy (2017), the total economic burden of bladder cancer was estimated 1.2 billion Euros; 44% of this rate resulted from the lost production costs [44]. Although productivity loss costs constitute a significant part of the economic burden of diseases, these costs are sometimes overlooked by policy makers and planners.

Since bladder cancer is more prevalent among the elderly [45], it is expected that its occurrence, prevalence, and cost increase with the population aging in the future years. According to estimations of Globocan 2018, due to demographic changes, the number of bladder cancer cases in Iran will increase by about 1.5–2 times in 2025 compared with 2018. Since the costs of diagnosis, treatment, and follow up of bladder cancer in early stages are significantly less than the progressed stages, early diagnosis and careful follow up and also, early detection of recurrence cases can decrease the costs of the patients’ treatment and follow up.

Strengths and constraints of the study

This research is the first study to investigate the economic burden of bladder cancer in Iran. One of the strengths of this study is the use of modeling for estimation of prevalence cases in terms of stage and the occurrence year.

Although this study has investigated a major part of the economic burden of bladder cancer in Iran, however, some of the costs have not been estimated due to lack of reliable data including direct nonmedical costs (the costs of travelling and accommodation in other cities for receiving treatment; the costs of information cares and treatments); intangible costs (decreased quality of life); the costs of relieving cares and the treatments provided in the late stages of bladder cancer patients’ life (hospitalization, receiving care in ICU wards, etc.); and hidden cost such as informal payment.

Furthermore, this study has investigated the economic burden of the 5-year prevalence cases bladder cancer in Iran; whereas, some patients may report the recurrence of disease after the 5th year and they may need to receive follow up. So, this disease can impose costs on patients after the 5th year. Therefore, in this study, the economic burden of bladder cancer estimations could be less than the real value.

The other constraint of this study is estimation of direct medical costs based on some assumptions of using treatment methods. As stated previously, we assumed that in Iran, all bladder cancer patients are treated in accordance with the clinical practice guideline published by the Ministry of Health, Treatment, and Medical Education. However, although some treatments are suggested by clinical practice guidelines, they may not be used by all physicians. In this situation, the real costs of the disease will be different from the costs estimated in this study.

Conclusion

Our results showed that the costs of bladder cancer, imposed on the healthcare system, were significant and mostly related to lost production costs and in early stages, medical costs are significantly lower than the costs of progressed stages. Considering the high cost of lost productivity due to mortality, the implementation of screening and diagnostic programs can improve the survival rate and quality of life of patients and reduce the cost of lost productivity due to mortality in these patients. Also, the results of this research can be used in economic evaluation studies to select interventions as well as preventive programs such as cancer awareness and screening programs.

Availability of data and materials

The data-sets used and/or analyzed during the current study available from the corresponding author on reasonable request.

Abbreviations

UBC:

Urinary bladder cancer

NMIBC:

Non-muscle invasive bladder cancer

MIBC:

Muscle invasive bladder cancer

CIS:

Carcinoma in situ

References

  1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49.

    Article  Google Scholar 

  2. Svatek RS, Hollenbeck BK, Holmäng S, Lee R, Kim SP, Stenzl A, et al. The economics of bladder cancer: costs and considerations of caring for this disease. Eur Urol. 2014;66(2):253–62.

    Article  Google Scholar 

  3. Rashidian H, Haghdoost AA, Daroudi R, Raadabadi M, Ebadzadeh MR, Zendehdel K. Estimating the Prevalence of bladder cancer by stage in Iran as a developing country. Med J Islam Repub Iran (MJIRI). 2022;36(1):283–7.

    Google Scholar 

  4. Bosset PO, Neuzillet Y, Paoletti X, Molinie V, Botto H, Lebret T. Long-term follow-up of TaG1 non–muscle-invasive bladder cancer. Urol Oncol. 2015. https://doi.org/10.1016/j.urolonc.2014.09.001.

    Article  Google Scholar 

  5. Benhamou S, Bonastre J, Groussard K, Radvanyi F, Allory Y, Lebret T. A prospective multicenter study on bladder cancer: the COBLAnCE cohort. BMC Cancer. 2016;16(1):837.

    Article  Google Scholar 

  6. Lebret T, Neuzillet Y. Indication and timing of cystectomy in high-risk bladder cancer. Curr Opin Urol. 2012;22(5):427–31.

    Article  Google Scholar 

  7. James AC, Gore JL. The costs of non-muscle invasive bladder cancer. Urol Clin North Am. 2013;40(2):261–9.

    Article  Google Scholar 

  8. Leal J, Luengo-Fernandez R, Sullivan R, Witjes JA. Economic burden of bladder cancer across the European Union. Eur Urol. 2016;69(3):438–47.

    Article  Google Scholar 

  9. Botteman MF, Pashos CL, Redaelli A, Laskin B, Hauser R. The health economics of bladder cancer: a comprehensive review of the published literature. Pharmacoeconomics. 2003;21(18):1315–30.

    Article  Google Scholar 

  10. John R, Ross H. Global economic cost of cancer. Atlanta: The American Cancer Society and LIVESTRONG; 2010.

    Google Scholar 

  11. Lang HC, Wu SL. Lifetime costs of the top five cancers in Taiwan. Eur J Health Econ. 2012;13(3):347–53.

    Article  Google Scholar 

  12. Max W, Sung HY, Stark B. The economic burden of breast cancer in California. Breast Cancer Res Treat. 2009;116(1):201–7.

    Article  Google Scholar 

  13. Yabroff KR, Lund J, Kepka D, Mariotto A. Economic burden of cancer in the United States: estimates, projections, and future research. Cancer Epidemiol Biomarkers Prev. 2011;20(10):2006–14.

    Article  Google Scholar 

  14. Brown ML, Yabroff KR. Economic impact of cancer in the United States. In: Schottenfeld D, Faumeni JF, editors. Cancer epidemiology and prevention. New York, NY: Oxford University Press; 2006. p. 209–2.

    Google Scholar 

  15. Drummond M. Cost-of-illness studies: a major headache? Pharmacoeconomics. 1992;2(1):1–4.

    Article  CAS  Google Scholar 

  16. Askarzade E, Adel A, Ebrahimipour H, Badiee Aval S, Pourahmadi E, Javan BA. Epidemiology and cost of patients with cancer in Iran: 2018. Middle East J Cancer. 2019;10(4):362–71.

    Google Scholar 

  17. Farokhi Noori M, Holakouie Naieni K, Haghdoost A, Emami A. Cost analysis for cancer subgroups in Kerman, IRAN. Iran J Epidemiol. 2012;8(1):62–70.

    Google Scholar 

  18. The ministry of health and medical education, treatment deputy, guideline development office, Iranian guidelines on diagnosis, treatment and surveillance of bladder cancer; 2015. (In Persian)

  19. Rashidian H, Zendehdel K, Daroudi R, Ebadzadeh MR, Haghdoost AA. Epidemiology and hospitalization cost of bladder cancer in Kerman Province, Southeastern Iran. Iran J Public Health. 2018;47(4):567.

    Google Scholar 

  20. Relative value of health services book in Iran. Third Edition ed. Tehran: Ministry of Health and Medical Education (MoHME); 2017

  21. National Formulary of IRAN. In: Food and Drug Administration MoHaME, editor. Tehran; 2018.

  22. Mennini FS, Gitto L. Approaches to estimating indirect costs in healthcare: motivations for choice. J Eur Econ. 2022. https://doi.org/10.35774/jee2022.01.017.

    Article  Google Scholar 

  23. Mohamed N, Diefenbach M, Goltz H, Lee C, Latini D, Kowalkowski M, et al. Muscle invasive bladder cancer: from diagnosis to survivorship. Adv Urol. 2012. https://doi.org/10.1155/2012/142135.

    Article  Google Scholar 

  24. Statistical Center of Iran, Iran statistical yearbook 2013–2014. https://nnt.sci.org.ir/sites/Apps/yearbook/Lists/year_book_req/Item/newifs.aspx?List=97c00882-734c-4417-831a-633d795b18ce&RootFolder=&Web=f9aca984-16ee-4860-8c00-bb43c696d32d. Accessed 22 Feb 2022.

  25. Ministry of Labour and Social Affair. https://bimeh.mcls.gov.ir/. Accessed 22 March 2021.

  26. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424.

    Article  Google Scholar 

  27. Haacker M, Hallett TB, Atun R. On discount rates for economic evaluations in global health. Health Policy Plan. 2020;35(1):107–14.

    Google Scholar 

  28. World Development Indicators database, World Bank. https://data.worldbank.org/indicator/PA.NUS.PPP?locations=IR. Accessed 11 Feb 2022.

  29. Mariotto AB, Robin Yabroff K, Shao Y, Feuer EJ, Brown ML. Projections of the cost of cancer care in the United States: 2010–2020. J Natl Cancer Inst. 2011;103(2):117–28.

    Article  Google Scholar 

  30. Furlow B. Expensive US cancer care: value for money? Lancet Oncol. 2012;13(5):e193.

    Article  Google Scholar 

  31. Avritscher EB, Cooksley CD, Grossman HB, Sabichi AL, Hamblin L, Dinney CP, et al. Clinical model of lifetime cost of treating bladder cancer and associated complications. Urology. 2006;68(3):549–53.

    Article  Google Scholar 

  32. Cooksley CD, Avritscher EB, Grossman HB, Sabichi AL, Dinney CP, Pettaway C, et al. Clinical model of cost of bladder cancer in the elderly. Urology. 2008;71(3):519–25.

    Article  Google Scholar 

  33. Han M, Schoenberg MP. The use of molecular diagnostics in bladder cancer. Urol Oncol Semin Orig Investig. 2000. https://doi.org/10.1016/S1078-1439(99)00052-6.

    Article  Google Scholar 

  34. Skolarus TA, Ye Z, Zhang S, Hollenbeck BK. Regional differences in early stage bladder cancer care and outcomes. Urology. 2010;76(2):391–6.

    Article  Google Scholar 

  35. Hollenbeck BK, Ye Z, Dunn RL, Montie JE, Birkmeyer JD. Provider treatment intensity and outcomes for patients with early-stage bladder cancer. J Natl Cancer Inst. 2009;101(8):571–80.

    Article  Google Scholar 

  36. Network NCC. NCCN clinical practice guidelines in oncology: bladder cancer (including upper tract tumors and urothelial carcinoma of the prostate); 2015. Fort Washington (PA): The Network; 2015.

  37. Babjuk M, Böhle A, Burger M, Capoun O, Cohen D, Compérat EM, et al. EAU guidelines on non–muscle-invasive urothelial carcinoma of the bladder: update 2016. Eur Urol. 2017;71(3):447–61.

    Article  Google Scholar 

  38. Hall MC, Chang SS, Dalbagni G, Pruthi RS, Seigne JD, Skinner EC, et al. Guideline for the management of nonmuscle invasive bladder cancer (stages Ta, T1, and Tis): 2007 update. J Urol. 2007;178(6):2314–30.

    Article  Google Scholar 

  39. Sievert KD, Amend B, Nagele U, Schilling D, Bedke J, Horstmann M, et al. Economic aspects of bladder cancer: what are the benefits and costs? World J Urol. 2009;27(3):295–300.

    Article  CAS  Google Scholar 

  40. Kilbridge K, Kantoff P, Loughlin K. Is bacillus calmette-guerin (BCG) immunotherapy cost-effective in recurrent high grade transitional cell cancer (TCC). J Urol. 1997;157(4):214.

    Google Scholar 

  41. Uchida A, Yonou H, Hayashi E, Iha K, Oda M, Miyazato M, et al. Intravesical instillation of bacille Calmette-Guerin for superficial bladder cancer: cost-effectiveness analysis. Urology. 2007;69(2):275–9.

    Article  Google Scholar 

  42. Madeb R, Golijanin D, Noyes K, Fisher S, Stephenson JJ, Long SR, et al. Treatment of nonmuscle invading bladder cancer: do physicians in the United States practice evidence based medicine? Cancer. 2009;115(12):2660–70.

    Article  Google Scholar 

  43. Yeung C, Dinh T, Lee J. The health economics of bladder cancer: an updated review of the published literature. Pharmacoeconomics. 2014;32(11):1093–104.

    Article  Google Scholar 

  44. Gerace C, Montorsi F, Tambaro R, Cartenì G, De Luca S, Tucci M, et al. Cost of illness of urothelial bladder cancer in Italy. Clinicoecon Outcomes Res. 2017;9:433–42.

    Article  Google Scholar 

  45. van Rhijn BW, Burger M, Lotan Y, Solsona E, Stief CG, Sylvester RJ, et al. Recurrence and progression of disease in non-muscle-invasive bladder cancer: from epidemiology to treatment strategy. Eur Urol. 2009;56(3):430–42.

    Article  Google Scholar 

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Acknowledgements

Authors would like to thank Kerman University of Medical Sciences in partially funding the study.

Funding

This Study Was Part of PhD Thesis Supported by Kerman University of Medical Sciences, Grant No: 9421.

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Authors and Affiliations

  1. Health Policy and Management Research Center, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Mehdi Raadabadi

  2. Department of Health Management, Policy and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

    Rajabali Daroudi

  3. Cancer Research Center, Cancer Institute of Iran, Imam Khomeini Hospital, Tehran University of Medical Sciences, Keshavarz Bulvard, PoBox: 13145-158, Tehran, Iran

    Kazem Zendehdel & Hamideh Rashidian

  4. Cancer Biology Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran

    Kazem Zendehdel

  5. HIV/STI Surveillance Research Center, and WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran

    Ali Akbar Haghdoost

  6. Department of Urology, Bahonar Hospital, Kerman University of Medical Sciences, Kerman, Iran

    Mohammad Reza Ebadzadeh

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Contributions

HR and AAH have designed the study and supervised the thesis. MR and RD collected the data and analyzed it. They also prepared the first draft of the manuscript. MRE and KZ has edited and finalized the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Hamideh Rashidian.

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Ethics approval and consent to participate

The article’s proposal was approved by the ethics committee of Kerman University of Medical Sciences with the ID of IR. Icmu.Rec.1394.104. Due to the retrospective nature of the study, no study specific consent form was used. However, patients admitted to our hospital are asked to sign a general consent upon admission, which covers the collection of patient data and publication of these results. We received administrative permission from (Secretary of University/Regional Research Ethics Committee, Kerman University of Medical Sciences) to access and use the data. Data used in the study were anonymized. The ethics committee approved this procedure with the above ethical code. The present study was conducted in terms of the principles of the revised Declaration of Helsinki.

Consent for publication

Not applicable.

Competing interests

All authors declare that they have no competing interest regarding this study.

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Raadabadi, M., Daroudi, R., Zendehdel, K. et al. Direct and indirect medical costs of bladder cancer in Iran. Cost Eff Resour Alloc 21, 5 (2023). https://doi.org/10.1186/s12962-023-00416-0

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  • DOI: https://doi.org/10.1186/s12962-023-00416-0

Keywords

Cost Effectiveness and Resource Allocation

ISSN: 1478-7547

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