- Open Access
Cost-effectiveness of cervical cancer screening and preventative cryotherapy at an HIV treatment clinic in Kenya
Cost Effectiveness and Resource Allocation volume 15, Article number: 13 (2017)
This study evaluated the potential cost-effectiveness of cervical cancer screening in HIV treatment clinics in Nairobi, Kenya.
A Markov model was used to project health outcomes and costs of cervical cancer screening and cryotherapy at an HIV clinic in Kenya using cryotherapy without screening, visual inspection with acetic acid (VIA), Papanicolaou smear (Pap), and testing for human papillomavirus (HPV). Direct and indirect medical and non-medical costs were examined from societal and clinic perspectives.
Costs of cryotherapy, VIA, Pap, and HPV for women with CD4 200–500 cells/mL were $99, $196, $219, and $223 from a societal perspective and $19, $94, $124, and $113 from a clinic perspective, with 17.3, 17.1, 17.1, and 17.1 years of life expectancy, respectively. Women at higher CD4 counts (>500 cells/mL) given cryotherapy VIA, Pap, and HPV resulted in better life expectancies (19.9+ years) and lower cost (societal: $49, $99, $115, and $102; clinic: $13, $51, $71, and $56). VIA was less expensive than HPV unless HPV screening could be reduced to a single visit.
Preventative cryotherapy was the least expensive strategy and resulted in highest projected life expectancy, while VIA was most cost-effective unless HPV could be reduced to a single visit.
Cancer is a growing cause of mortality worldwide, and cervical cancer is one of the leading causes of cancer death in sub-Saharan Africa (SSA) . Although preventable if detected early, cervical cancer is one of the most prevalent cancers on the continent with 75,000 incident cases per year [2, 3]. In addition to the cancer burden, more than 10 million women are infected with HIV and are therefore at greater risk for cervical cancer and early mortality, making early detection and prevention critical for this already vulnerable population [4, 5].
Reducing cervical cancer among HIV-infected women is a primary focus of the Pink Ribbon Red Ribbon Initiative, a joint public–private international program launched in 2011 supported by the President’s Emergency Plan for AIDS Relief (PEPFAR) . The initiative promotes integrating cervical cancer screening and treatment into HIV treatment clinics in sub-Saharan Africa . Understanding the cost-effectiveness of each cervical cancer screening method in an integrated context is essential to meeting the goals of the Initiative and to sustaining cervical cancer screening programs during a period of decreasing PEPFAR funding .
Our recent cross-sectional study at an HIV treatment clinic in Kenya in which 498 women all received Pap, VIA, and HPV screening, found human papilloma virus testing with a Cervex brush in PreservCyt media (HPV) to be the most sensitive cervical cancer screening method among HIV-infected women (81%) followed by Pap smear (74%) and visual inspection with acetic acid (VIA) (61%), while Pap smear was the most specific (98%) followed by VIA (63%) and HPV (55%) . However, VIA screening and treatment has been shown to be feasible, acceptable, and effective in detecting and treating pre-cancerous cervical lesions [8,9,10,11,12,13,14,15,16]. In Kenya, VIA, VIA/VILI, Pap, and HPV are all recommended for screening in Kenya , though the World Health Organization (WHO) recommends human papillomavirus (HPV)-based screening tests in countries that have not established an effective, high-coverage Pap-based program .
Furthermore, a recent abstract suggested that preventative cryotherapy for women of screening age may yield greater health benefits than once-in-a-lifetime screening . Cryotherapy has been shown to be effective and have relatively low risks [20, 21]. Particularly in settings where access to screening or cancer treatment may be limited, preventative cryotherapy may be an effective and affordable alternative.
In this study we compared the cost-effectiveness of Pap, VIA, and HPV screening, combinations of these screens, and preventative cryotherapy in an HIV clinic using primary cost data and screening test sensitivity and specificity based on the gold standard of colposcopy-directed biopsy. We modeled the costs and effectiveness of each cervical cancer screening strategy over the lifetime of an average HIV-infected patient to estimate which methods might be provide the best health outcomes while minimizing costs.
Study site and population
The Coptic Hope Center for Infectious Diseases in Nairobi, Kenya, is an HIV comprehensive care clinic where HIV-infected men, women, and children receive antiretroviral therapy (ART) and treatment for opportunistic infections . The Hope Center was established in 2004 by the University of Washington and the Coptic Christian Mission with funding from PEPFAR through the Centers for Disease Control and Prevention (CDC). Cervical cancer screening has been offered at the Hope Center since 2005 with over 7000 HIV-infected women having been screened to date .
In 2009, we conducted a cross-sectional study of cervical cancer screening with 498 HIV-infected women at the Hope Center to compare VIA, Pap smear, and HPV (Cervex brush with PreservCyt media) against the gold colposcopy-directed biopsy . Sensitivity, specificity, and overall accuracy of each screening method (defined by area under the receiver operator curve) were compared using pairwise tests and multivariable logistic regression models that included age, CD4 count, and ART duration. The cost analysis presented here was based on resource use for each method derived from the Coptic Hope Center.
Natural history model
A Markov model was used to simulate the natural history of cervical cancer in HIV-infected women based on a framework by Goldie et al. . that has been used extensively to model cervical cancer among HIV-infected patients [24,25,26]. In the model, the health states represented HPV DNA status, the grade of lesion, and the stage of invasive cancer (Fig. 1). Movement through the health states occurred in monthly increments according to probabilities (Table 1). Costs and benefits were discounted at an annual rate of 3% (0.25% monthly), consistent with economic guidelines . Modeling was completed using TreeAge Pro 2013 .
Model and strategies
Clinical strategies included: Pap smear, VIA, HPV, Pap plus VIA, Pap plus HPV, VIA plus Pap, and preventative cryotherapy with no screen (Fig. 1). For strategies including an HPV screen, women were considered to have a positive diagnosis if they tested positive for high-risk HPV types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 or 68. For strategies including a Pap smear, women were considered to have a positive diagnosis if they had high-grade squamous intra-epithelial lesions or greater (HSIL+). True test positivity was defined as having CIN 2/3 or greater by colposcopy-directed biopsy. Each woman was assumed to receive a single screening for cervical cancer during her lifetime at 38 years of age, which was the mean age of women in the screening study.
Test performance (sensitivity and specificity) data was based on our recent cross-sectional study at an HIV treatment clinic in Kenya (Table 1) . The median age of the population was 38 years and 57% were under age 50 . Nearly half (43%) of the participants were married, and 51% had at least a secondary school education. Most women (77%) were employed, none reported any smoking history, and 25% reported having 3 or more lifetime sexual partners . The median CD4 count at the time of cervical cancer screening was 371 cells/mL, with 16% having a low CD4 count (<200 cells/mL), and 28% having a high CD4 count (>500 cells/mL) . Three hundred and seventy-seven women (75%) were on ART at the time of cervical cancer screening, and 182 (48%) of these women had been on ART for >2 years . Those on ART had been taking antiretroviral medications for a median duration of 797 days (IQR 330–1210) .
For this model, women could receive screening and treatment in one, two or three visits. In a single-visit strategy, VIA screen and treatment with cryotherapy or LEEP were modeled to occur on the same day. Two-visit strategies consisted of an HPV or Pap screen, followed by provision of results and treatment (as needed) during a follow-up visit. Three-visit strategies included an initial screening visit, a second confirmatory screening visit for all women with positive results, and a treatment visit for all women with two positive results. We assumed a base case of loss to follow-up (LTFU) of 32% based on studied LTFU rates for cervical cancer screening in an ART clinic in Kenya . Treatment options included cryotherapy, loop electrosurgical excision procedure (LEEP), hysterectomy, chemotherapy, radiotherapy, and palliative care (Table 2). For treatment for high-grade lesions, 80% of women received cryotherapy and 20% received LEEP.
Table 1 shows selected variables based on published literature. Primary data from Coptic Hope Center was used whenever possible. We used literature values from Kenya, SSA, or low-income settings to supplement when primary data was unavailable. The base case model represented women with CD4 count 200–500 cells/mL. Progression, regression, and mortality rates were not dependent on a previous history of lesions or cancer, therefore, potential for cancer recurrence was not included (parameters were aggregate representations of populations that included women with and without a history of lesions and cancer). Mortality rates were age-specific and sensitivity and specificity of screening was binary for age <40 and ≥40 at time of screen. Background mortality rates for the population were WHO age-specific all-cause mortality rates for Kenyan females in 2011 .
A quantity-and-price approach was used to estimate costs, based on primary data collected through a micro-costing study at Coptic Hope Center for Infectious Diseases and Kenyatta National Hospital, Kenya, between July 1 and October 31, 2014 . Direct medical, non-medical, and indirect costs were estimated using a time-and-motion study ad semi-structured interviews with patients and clinic staff. This study found VIA to cost $3.30, careHPV to cost $18.28, and pap Pap to cost $24.59 per screen . Indirect costs were lower for single-visit screening methods ($0.43 per screening) than two-visit screening methods ($2.88 per screening) . Costs are presented in 2014 US dollars, the year of the costing study. The study team at Coptic Hope Center procures their supplies from local vendors and international supply distributors. As an HIV-treatment center, costs at Coptic Hope Center may differ from primary care and non-specialized public health facilities. However, our costs estimates were reasonably comparable to estimates from other HIV-treatment and public health facilities previously reported for Kenya and SSA .
Costs were categorized as direct medical costs (e.g. staff time, medical supplies), direct non-medical costs (e.g. overhead, patient transportation costs), and indirect costs (e.g. patient time, child care). The analysis was completed using two perspectives for cost. First, a societal perspective included direct medical, direct non-medical, and indirect costs to the health center, patient, and caregiver. This perspective accounts for patient out-of-pocket costs and the economic opportunity costs (e.g., missed wages) associated with a patient or caregiver’s time lost while receiving care. Second, a clinic perspective included direct medical and direct non-medical costs for the health care center only.
Costs included for each health state are shown in Table 2, delineated separately for the first month of treatment and subsequent months of treatment. For individuals with local, regional or distant invasive cancer, 3 round-trip visits entailed: (1) examination under anesthesia for staging and diagnosis, (2) minor theater day/first treatment, and (3) one return visit for histology report and/or development of management plan. HPV screening costs were modeled on the projected use of careHPV . Cost of preventative cryotherapy included patient out-of-pocket costs, personnel, supplies, patient transport, non-medical costs, overhead, and lost wages. Costs included expenses resulting from false positive diagnoses and treatment complications.
Preventative cryotherapy was projected to have the lowest mean lifetime cost of screening and treatment ($99, societal perspective; $19, clinic perspective), as well as lead to the highest projected life expectancy (17.3 years from time of screening to death) (Table 3). VIA, Pap screening and HPV screening had higher projected mean lifetime costs of screening and treatment ($196, $219, $223, societal perspective; $94, $124, $113, clinic perspective, respectively), and lower life expectancy (17.1 years). The combination strategies of VIA + HPV, HPV + Pap, and VIA + Pap had higher mean lifetime costs of screening and treatment ($258, $261, and $263, societal perspective; $150, $155, and $158, perspective, respectively) and lower life expectancy (17.0 years).
When the number of visits was reduced from two to one for Pap and for HPV in scenario analyses, the projected mean lifetime costs of screening and treatment decreased (from $219 to $168 for Pap and from $223 to $169 for HPV, societal perspective). Additionally, the years of life expectancy for Pap remained the same (17.1 years), but increased for HPV (from 17.1 to 17.2 years).
All treatment strategies among women with a CD4 count ≤200 cells/mL at time of screening yielded projected years of life that were approximately two years lower than women who had CD4 count 200–500 cells/mL. Among women with CD4 count ≤200 cells/mL, preventative cryotherapy remained the least expensive ($122, societal perspective; $22, clinic perspective) and had the highest life expectancy (15.3 years) (Table 3). Among women with CD4 count >500 cells/mL at time of screening, all treatment strategies increased projected life expectancies by approximately 2 years but decreased costs compared to women with CD4 200–500 cells/mL. Preventative cryotherapy remained the least expensive strategy ($49, societal perspective; $13, clinic perspective) with the highest projected life expectancy (20.0 years) (Table 3).
Preventative cryotherapy was less expensive than VIA in all one-way sensitivity analyses, and VIA was less expensive than HPV in almost all analyses (Fig. 2). Holding all other variables constant, HPV was projected to have the same cost as VIA when LTFU was lowered from the base case (32%) to 17%.
Preventative cryotherapy without screening was projected to be the least expensive strategy for preventing cervical cancer in HIV-infected women and led to the highest projected life expectancy compared to VIA, Pap, HPV, and their combinations. Of the screening strategies, VIA was the least expensive and led to the highest projected life expectancy. If HPV could be reduced to a 1-visit strategy, it would be projected to be less expensive than VIA. For all screening strategies, was least costly and most effective to intervene on women with any test at CD4 counts >500 cells/mL.
Our results supported previous work that found preventative cryotherapy to be a cost-effective intervention in LMICs . Given the high rate of test positivity in our HIV-infected population, the expense of screening, and the increased potential for LTFU in this resource-limited setting, it appears less expensive and more effective to treat all women with cryotherapy preventively. Prophylactic cryotherapy may also prevent acquisition of HPV that can lead to cervical cancer among those who test negative . Cryotherapy may result in minor adverse events such as vaginal discharge, abdominal/lower back pain, or vaginal bleeding . However, since cryotherapy appears safe to use without severe adverse effects related to pregnancy and without necessarily causing increased shedding of HIV virus from the cervix [35,36,37], it merits further investigation as a treatment tool that could help all women enrolled in an HIV clinic.
When comparing traditional screening methods, our results were consistent with other studies in LMICs that found VIA to be a cost-effective screening method for cervical cancer [11,12,13,14,15,16, 38]. Several studies have demonstrated that integration of VIA into routine HIV care in Africa is feasible and acceptable [39,40,41,42]. The results presented here further support integration of cervical cancer screening and HIV care. An overarching goal of the WHO global health sector strategy on HIV/AIDS is to achieve universal access to comprehensive HIV prevention, treatment, and care, including strengthening linkages between HIV and other related health programs, such as cervical cancer screening and treatment . Demonstrating that cervical cancer screening or preventative treatment is a cost-effective strategy in this setting is an important step towards successfully reaching that goal. With combined efforts of the research community and organizations, such as the Pink Ribbon Red Ribbon campaign, integration into HIV settings would allow for many more women with cervical cancer to receive screening and treatment.
In contrast to our findings, some evaluations of non-integrated settings found HPV screening to be a more cost-effective screening method than VIA [44, 45]. Our model used primary, current data of costs and test sensitivity when providing screening in an integrated setting. Our cost estimates included direct and indirect costs over the lifetime of the patient, whereas other studies used narrower definitions of costs and time horizons [44, 45]. These factors likely led to the difference in conclusion from previous studies. Other studies also may differ due to variations in the assumptions made related to number of visits and timing of treatment, which have been shown to be of key importance regardless of screening type [13, 46,47,48]. Finally, a SIL-based model was used here rather than a CIN-based model since the SIL-framework has been used more extensively for HIV-infected populations in LMICs [12, 13, 23, 24]. Studies that chose to use a CIN-based model or an non-HIV-infected population also found VIA and/or Pap screening to be cost-effective methods of screening [44, 49,50,51]. We do not expect that our results would change if we had chosen to use a CIN-based model. Our results did show that if patients could receive HPV screening and treatment in a single visit (i.e., same day see-and-treat), HPV would be projected to be less expensive than VIA with equivalent or better health outcomes. Although single visit screening may be advantageous in some respects, it could lead to longer patient wait times on that day and require logistical changes for facility procedures.
This study had several limitations. First, a Markov model does not take into account disease history, such as prior lesions or changes in CD4 over time, which may impact results. Second, all strategies considered here assume that women only receive one screening per lifetime, and do not consider periodic screenings or optimal age for screening. Third, screening implementation costs such as social mobilization or demand creation were not included, which could be a barrier for a health facility considering adding screening to their current clinic services. However, HIV treatment centers generally support an already engaged population, since many patients seek services on a monthly basis for prescription refills and checkups; therefore, costs of demand generation would likely be minimal.
This study offers a societal and clinic perspective of costs of cervical cancer screening or preventative treatment. Data from a screening trial and cost study in the same clinic setting increases the strength of our analysis. There are likely many advantages to providing screening in an HIV clinic, including decreased LTFU and availability of trained nurses. However, future studies evaluating the ideal age and timing of screen among HIV-infected women would be of particular value to decision-makers and health providers. Additionally, trials should be undertaken to better understand long-term treatment effectiveness in an HIV-infected population, particularly for preventative cryotherapy.
Our results project preventative cryotherapy to be more cost-effective than cervical cancer screening for HIV-infected women. Ethical concerns for this strategy do need to be addressed, particularly for implementation in a vulnerable population such as HIV-infected women. Among screening methods, we found VIA to be the least expensive and lead to the highest life expectancy, unless HPV screening could be reduced to a single visit, in which case it may become less expensive than VIA. As such, future health systems research should focus on decrease the number of healthcare visits required for an HPV screen. Both preventative cryotherapy and VIA may be considered for widespread implementation among HIV-infected women in low-income settings.
Bray F, Ren J-S, Masuyer E, Ferlay J. Global estimates of cancer prevalence for 27 sites in the adult population in 2008. Int J Cancer. 2013;132:1133–45. doi:10.1002/ijc.27711.
Ferlay J, Shin H, Bray F, Forman D, Mathers C, Parkin D. GLOBOCAN 2008 v2.0, Cancer incidence and mortality worldwide: IARC cancer base No. 10. Lyon: International Agency for Research on Cancer; 2010.
Arbyn M, Castellsagué X, de Sanjosé S, Bruni L, Saraiya M, Bray F, et al. Worldwide burden of cervical cancer in 2008. Ann Oncol. 2011;22:2675–86. doi:10.1093/annonc/mdr015.
Joint United Nations Programme on HIV/AIDS (UNAIDS). UNAIDS report on the global AIDS epidemic 2013; 2013. http://www.unaids.org/en/media/unaids/contentassets/documents/epidemiology/2013/gr2013/UNAIDS_Global_Report_2013_en.pdf.
Schuman P, Ohmit SE, Klein RS, Duerr A, Cu-Uvin S, Jamieson DJ, et al. Longitudinal study of cervical squamous intraepithelial lesions in human immunodeficiency virus (HIV)-seropositive and at-risk HIV-seronegative women. J Infect Dis. 2003;188:128–36. doi:10.1086/375783.
Pink Ribbon Red Ribbon Who We Are. http://pinkribbonredribbon.org/who-we-are/. Accessed 21 Sept 2015.
Chung MH, McKenzie KP, De Vuyst H, Richardson BA, Rana F, Pamnani R, et al. Comparing pap smear, via, and hpv cervical cancer screening methods among HIV-positive women by immune status and antiretroviral therapy. AIDS. 2013. doi:10.1097/01.aids.0000432472.92120.1b.
Mwanahamuntu MH, Sahasrabuddhe VV, Kapambwe S, Pfaendler KS, Chibwesha C, Mkumba G, et al. Advancing cervical cancer prevention initiatives in resource-constrained settings: insights from the cervical cancer prevention program in Zambia. PLoS Med. 2011;8:e1001032. doi:10.1371/journal.pmed.1001032.
Pfaendler KS, Mwanahamuntu MH, Sahasrabuddhe VV, Mudenda V, Stringer JSA, Parham GP. Management of cryotherapy-ineligible women in a “screen-and-treat” cervical cancer prevention program targeting HIV-infected women in Zambia: lessons from the field. Gynecol Oncol. 2008;110:402–7. doi:10.1016/j.ygyno.2008.04.031.
Moon TD, Silva-Matos C, Cordoso A, Baptista AJ, Sidat M, Vermund SH. Implementation of cervical cancer screening using visual inspection with acetic acid in rural Mozambique: successes and challenges using HIV care and treatment programme investments in Zambézia Province. J Int AIDS Soc. 2012;15:17406.
Mandelblatt JS, Lawrence WF, Gaffikin L, Limpahayom KK, Lumbiganon P, Warakamin S, et al. Costs and benefits of different strategies to screen for cervical cancer in less-developed countries. J Natl Cancer Inst. 2002;94:1469–83.
Goldie SJ, Kuhn L, Denny L, Pollack A, Wright TC. Policy analysis of cervical cancer screening strategies in low-resource settings: clinical benefits and cost-effectiveness. JAMA J Am Med Assoc. 2001;285:3107–15.
Goldie SJ, Gaffikin L, Goldhaber-Fiebert JD, Gordillo-Tobar A, Levin C, Mahé C, et al. Cost-effectiveness of cervical-cancer screening in five developing countries. N Engl J Med. 2005;353:2158–68. doi:10.1056/NEJMsa044278.
Gaffikin L, Blumenthal PD, Emerson M, Limpaphayom K, Royal Thai College of Obstetricians and Gynaecologists (RTCOG)/JHPIEGO Corporation Cervical Cancer Prevention Group [corrected]. Safety, acceptability, and feasibility of a single-visit approach to cervical-cancer prevention in rural Thailand: a demonstration project. Lancet. 2003;361:814–20.
Sankaranarayanan R, Esmy PO, Rajkumar R, Muwonge R, Swaminathan R, Shanthakumari S, et al. Effect of visual screening on cervical cancer incidence and mortality in Tamil Nadu, India: a cluster-randomised trial. Lancet. 2007;370:398–406. doi:10.1016/S0140-6736(07)61195-7.
Shastri SS, Mittra I, Mishra GA, Gupta S, Dikshit R, Singh S, et al. Effect of VIA screening by primary health workers: randomized controlled study in Mumbai, India. J Natl Cancer Inst. 2014;106:dju009. doi:10.1093/jnci/dju009.
Kenya Ministry of Health. National guidelines for cancer management Kenya; 2013. http://kehpca.org/wp-content/uploads/National-Cancer-Treatment-Guidelines2.pdf. Accessed 11 Feb 2016.
WHO. WHO Guidelines for screening and treatment of precancerous lesions for cervical cancer prevention. http://www.who.int/reproductivehealth/publications/cancers/screening_and_treatment_of_precancerous_lesions/en/. Accessed 21 Sept 2015.
Campos N, Geng F, Lee K, Jeronimo J, Feldman S, Kim J. HPV15-0414 Public health/epidemiology–economics and mathematical modeling the cost-effectiveness of universal cryotherapy for women of screening age in low-resource settings. In: 30th International Papillomavirus Conference, Lisbon, Portugal; 2015.
Nene BM, Hiremath PS, Kane S, Fayette J-M, Shastri SS, Sankaranarayanan R. Effectiveness, safety, and acceptability of cryotherapy by midwives for cervical intraepithelial neoplasia in Maharashtra. India Int J Gynaecol Obstet. 2008;103:232–6. doi:10.1016/j.ijgo.2008.07.016.
Chamot E, Kristensen S, Stringer JSA, Mwanahamuntu MH. Are treatments for cervical precancerous lesions in less-developed countries safe enough to promote scaling-up of cervical screening programs? A systematic review. BMC Womens Health. 2010;10:11. doi:10.1186/1472-6874-10-11.
Chung MH, Drake AL, Richardson BA, Reddy A, Thiga J, Sakr SR, et al. Impact of prior HAART use on clinical outcomes in a large Kenyan HIV treatment program. Curr HIV Res. 2009;7:441–6.
Goldie SJ, Weinstein MC, Kuntz KM, Freedberg KA. The costs, clinical benefits, and cost-effectiveness of screening for cervical cancer in HIV-infected women. Ann Intern Med. 1999;130:97–107.
Atashili J, Smith JS, Adimora AA, Eron J, Miller WC, Myers E. Potential impact of antiretroviral therapy and screening on cervical cancer mortality in HIV-positive women in sub-Saharan Africa: a simulation. PLoS ONE. 2011;6:e18527. doi:10.1371/journal.pone.0018527.
Demarteau N, Detournay B, Tehard B, El Hasnaoui A, Standaert B. A generally applicable cost-effectiveness model for the evaluation of vaccines against cervical cancer. Int J Public Health. 2011;56:153–62. doi:10.1007/s00038-010-0216-6.
Goldhaber-Fiebert JD, Stout NK, Ortendahl J, Kuntz KM, Goldie SJ, Salomon JA. Modeling human papillomavirus and cervical cancer in the United States for analyses of screening and vaccination. Popul Health Metr. 2007;5:11. doi:10.1186/1478-7954-5-11.
Shepard DS. Cost-effectiveness in Health and Medicine. In: Gold MR, Siegel JE, Russell LB, Weinstein MC, editors. New York: Oxford University Press, 1996. J Ment Health Policy Econ. 1999;2:91–2.
TreeAge Software, Williamstown, Inc. :MA 01267. Home. https://www.treeage.com/. Accessed 22 May 2015.
Khozaim K, Orang’o E, Christoffersen-Deb A, Itsura P, Oguda J, Muliro H, et al. Successes and challenges of establishing a cervical cancer screening and treatment program in western Kenya. Int J Gynaecol Obstet. 2013. doi:10.1016/j.ijgo.2013.06.035.
WHO. WHO data repository Kenya 2011. http://apps.who.int/gho/data/view.main. Accessed 13 Jan 2014.
Vodicka EL, Babigumira JB, Mann MR, Kosgei RJ, Lee F, Mugo NR, et al. Costs of integrating cervical cancer screening at an HIV clinic in Kenya. Int J Gynecol Obstet. 2017;136:220–8. doi:10.1002/ijgo.12025.
Ying H, Jing F, Fanghui Z, Youlin Q, Yali H. High-risk HPV nucleic acid detection kit-the careHPV test—a new detection method for screening. Sci Rep. 2014. doi:10.1038/srep04704.
Franceschi S. Embryonic cells in the squamous-columnar junction of the cervix: scope for prophylactic ablation? Int J Cancer. 2015;136:989–90. doi:10.1002/ijc.29057.
Lewis KDC, Sellors JW, Dawa A, Tsu VD, Kidula NA. Report on a cryotherapy service for women with cervical intraepithelial neoplasia in a district hospital in western Kenya. Afr Health Sci. 2011;11:370–6.
Arbyn M, Kyrgiou M, Simoens C, Raifu AO, Koliopoulos G, Martin-Hirsch P, et al. Perinatal mortality and other severe adverse pregnancy outcomes associated with treatment of cervical intraepithelial neoplasia: meta-analysis. BMJ. 2008;337:a1284.
Castanon A, Brocklehurst P, Evans H, Peebles D, Singh N, Walker P, et al. Risk of preterm birth after treatment for cervical intraepithelial neoplasia among women attending colposcopy in England: retrospective-prospective cohort study. BMJ. 2012;345:e5174.
Chung MH, McKenzie KP, Richardson BA, John-Stewart GC, Coombs RW, De Vuyst H, et al. Cervical HIV-1 RNA shedding after cryotherapy among HIV-positive women with cervical intraepithelial neoplasia stage 2 or 3. AIDS. 2011;25:1915–9. doi:10.1097/QAD.0b013e32834a3654.
Lince-Deroche N, Phiri J, Michelow P, Smith JS, Firnhaber C. Costs and cost effectiveness of three approaches for cervical cancer screening among HIV-positive women in Johannesburg, South Africa. PLoS ONE. 2015;10:e0141969. doi:10.1371/journal.pone.0141969.
Ramogola-Masire D, de Klerk R, Monare B, Ratshaa B, Friedman HM, Zetola NM. Cervical cancer prevention in HIV-infected women using the “see and treat” approach in Botswana. J Acquir Immune Defic Syndr. 2012;59:308–13. doi:10.1097/QAI.0b013e3182426227.
Huchko MJ, Bukusi EA, Cohen CR. Building capacity for cervical cancer screening in outpatient HIV clinics in the Nyanza province of western Kenya. Int J Gynaecol Obstet. 2011;114:106–10. doi:10.1016/j.ijgo.2011.02.009.
Horo A, Jaquet A, Ekouevi DK, Toure B, Coffie PA, Effi B, et al. Cervical cancer screening by visual inspection in Côte d’Ivoire, operational and clinical aspects according to HIV status. BMC Public Health. 2012;12:237. doi:10.1186/1471-2458-12-237.
Mwanahamuntu MH, Sahasrabuddhe VV, Blevins M, Kapambwe S, Shepherd BE, Chibwesha C, et al. Utilization of cervical cancer screening services and trends in screening positivity rates in a “screen-and-treat” program integrated with HIV/AIDS care in Zambia. PLoS ONE. 2013;8:e74607. doi:10.1371/journal.pone.0074607.
WHO Global health sector strategy on HIV/AIDS 2011–2015. http://www.who.int/hiv/pub/hiv_strategy/en/. Accessed 2 Oct 2015.
de Kok IMCM, van Rosmalen J, Dillner J, Arbyn M, Sasieni P, Iftner T, et al. Primary screening for human papillomavirus compared with cytology screening for cervical cancer in European settings: cost effectiveness analysis based on a Dutch microsimulation model. BMJ. 2012;344:e670.
Shi J-F, Canfell K, Lew J-B, Zhao F-H, Legood R, Ning Y, et al. Evaluation of primary HPV-DNA testing in relation to visual inspection methods for cervical cancer screening in rural China: an epidemiologic and cost-effectiveness modelling study. BMC Cancer. 2011;11:239. doi:10.1186/1471-2407-11-239.
Kulasingam SL, Havrilesky LJ, Ghebre R, Myers ER. Screening for cervical cancer: a modeling study for the US preventive services task force. J Low Genit Tract Dis. 2013;17:193–202. doi:10.1097/LGT.0b013e3182616241.
Demarteau N, Breuer T, Standaert B. Selecting a mix of prevention strategies against cervical cancer for maximum efficiency with an optimization program. Pharmacoeconomics. 2012;30:337–53. doi:10.2165/11591560-000000000-00000.
Kulasingam SL, Rajan R, St Pierre Y, Atwood CV, Myers ER, Franco EL. Human papillomavirus testing with Pap triage for cervical cancer prevention in Canada: a cost-effectiveness analysis. BMC Med. 2009;7:69. doi:10.1186/1741-7015-7-69.
Bistoletti P, Sennfält K, Dillner J. Cost-effectiveness of primary cytology and HPV DNA cervical screening. Int J Cancer. 2008;122:372–6. doi:10.1002/ijc.23124.
Praditsitthikorn N, Teerawattananon Y, Tantivess S, Limwattananon S, Riewpaiboon A, Chichareon S, et al. Economic evaluation of policy options for prevention and control of cervical cancer in Thailand. Pharmacoeconomics. 2011;29:781–806. doi:10.2165/11586560-000000000-00000.
Siebert U, Sroczynski G, Hillemanns P, Engel J, Stabenow R, Stegmaier C, et al. The German cervical cancer screening model: development and validation of a decision-analytic model for cervical cancer screening in Germany. Eur J Public Health. 2006;16:185–92. doi:10.1093/eurpub/cki163.
Maranga IO, Hampson L, Oliver AW, Gamal A, Gichangi P, Opiyo A, et al. Analysis of factors contributing to the low survival of cervical cancer patients undergoing radiotherapy in Kenya. PLoS ONE. 2013;8:e78411. doi:10.1371/journal.pone.0078411.
Rodger AJ, Lodwick R, Schechter M, Deeks S, Amin J, Gilson R, et al. Mortality in well controlled HIV in the continuous antiretroviral therapy arms of the SMART and ESPRIT trials compared with the general population. AIDS. 2013;27:973–9. doi:10.1097/QAD.0b013e32835cae9c.
All authors made substantial contributions to this work. Additionally, all authors contributed to drafting or revising this manuscript, and approved the final version for submission. All authors agree to be accountable for all aspects of this work. MRZ completed analyses and drafted manuscript, EV completed costing analyses and reviewed manuscript, JBB oversaw economic analyses and reviewed manuscript, TO, NM, and SS led clinical applicability, designed scenarios, and reviewed manuscript, LPG guided economic methods and reviewed manuscript, and MHC oversaw the project and collaboration and reviewed and guided manuscript drafting and submission. All authors read and approved the final manuscript.
The authors have no acknowledgements to report.
The authors declare that they have no competing interests.
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