Skip to main content

Cost-effectiveness analysis of imaging surveillance in stage II and III extremity soft tissue sarcoma: an Australian perspective

Abstract

Background

Surveillance imaging is used to detect local and/or distant recurrence following primary treatment of localised soft tissue sarcoma (STS), however evidence supporting optimal surveillance modality or frequency is lacking. We used prospectively collected sarcoma data to describe current surveillance imaging practice in patients with AJCC stage II and III extremity STS and evaluate its cost-effectiveness.

Methods

From three selected Australian sarcoma referral centres, we identified patients with stage II and III extremity STS treated between 2009 and 2013. Medical records were reviewed to ascertain surveillance imaging practices, including modality, frequency and patient outcomes. A discrete event simulation model was developed and calibrated using clinical data to estimate health service costs and quality adjusted life years (QALYs) associated with alternative surveillance strategies.

Results

Of 133 patients treated for stage II and III extremity STS, the majority were followed up with CT chest (86%), most commonly at 3-monthly intervals and 62% of patients had the primary site imaged with MRI at 6-monthly. There was limited use of chest-X-ray. A discrete event simulation model demonstrated that CT chest screening was the most cost effective surveillance strategy, gaining additional QALYs at a mean incremental cost of $30,743. MRI alone and PET-CT alone were not cost-effective, whilst a combined strategy of CT + MRI had an incremental cost per QALY gained of $96,556.

Conclusions

Wide variations were observed in surveillance imaging practices in this high-risk STS cohort. Modelling demonstrated the value of CT chest for distant recurrence surveillance over other forms of imaging in terms of cost and QALYs. Further work is required to evaluate cost-effectiveness in a prospective manner.

Background

Soft tissue sarcomas (STS) are rare malignant tumours arising from mesenchymal cells, which predominantly occur at the extremities [1]. In 2009, the incidence rate of STS was reported to be 6.12 per 100,000 Australian population, significantly increased by more than 50% from that in 1982 [2]. Local treatment with surgery with or without radiotherapy is the mainstay treatment for localised disease with the use of systemic therapy reserved for selected subtypes to optimise the chance of cure [3]. Surveillance following completion of primary treatment aims to identify local or distant recurrence at a stage when surgical intervention may improve overall survival or enable further limb conservation [4,5,6,7,8,9,10,11]. In particular, early identification and treatment of oligometastatic lung metastases has been shown to improve overall survival [6,7,8,9,10,11].

Evidence supporting international guidelines on optimal STS follow-up is poor [3, 12, 13]. Surveys demonstrate wide variation in surveillance imaging practices within the sarcoma specialist community [14,15,16]. In recent decades, new imaging modalities, such as magnetic resonance imaging (MRI) and positron emission tomography (PET) have become widely available. However, the relative merits of these imaging modalities in surveillance, in comparison to X-ray or CT remains to be defined. Increased consumer demand for imaging must be balanced with rising health care expenditure and the risks of over-investigation, increased radiation exposure and patient anxiety [1, 17, 18].

Most available evidence for optimal interval and modality of imaging surveillance comes from single centre experiences, which report conflicting results on superiority of CT chest over chest X-ray in detecting lung metastases, amenable for salvage metastastectomy [19,20,21,22,23]. Some have supported the role of surveillance MRI for early detection of asymptomatic local recurrence, whilst others have advocated the less intensive surveillance with chest X-ray and patient education about examination of the site of surgery with no detrimental effect on overall survival [24,25,26,27]. The ideal ‘gold-standard’ method to develop evidence-based practice would be to conduct a large multi-centre randomised controlled trial (RCT) to examine the surveillance imaging practice of varying modality and frequency. However, RCTs are costly, and may take many years to complete to reach statistical and clinical significance. A novel strategy to develop evidence-based guidelines is to predict the costs and utility of alternative surveillance imaging strategies in STS patient population using a model-based cost effectiveness analysis [28,29,30,31].

Our study was designed to utilise an Australian sarcoma database to describe current surveillance imaging practices in a high-risk patient cohort with localised extremity STS and assess cost-effectiveness using a discrete event simulation model.

Methods

Data from three Australian sarcoma services were used to describe surveillance pathways and outcomes. A published cost-effectiveness model of alternative surveillance strategies for early breast cancer patients was adapted to replicate the patterns of recurrent cancer and death in patients diagnosed with high-risk localised extremity STS [32]. The model was populated using published evidence on progression of localised extremity STS, costs and health-related quality of life weights. Primary data was used to calibrate the model by comparing predicted and observed survival associated with observed surveillance pathways. This study was approved by the Human Research Ethics Committee at each site.

Patient population

Patients were 18 years and older with American Joint Committee on Cancer (AJCC) Stages II and III (Grade 2 or 3, T1a to T2bN0M0) extremity STS, diagnosed between 1 January 2009 and 31 December 2013 and managed with curative-intent treatment. Patients’ follow-up surveillance imaging data were collected from medical records. To minimise heterogeneity within the cohort, sarcoma subtypes of extraosseous Ewing sarcoma, extraosseous osteosarcoma, and rhabdomyosarcoma were excluded.

Model structure

The cost-effectiveness model was implemented as a discrete event simulation due to the use of individual level patient data to populate and calibrate the model (Fig. 1). Patients enter the model disease-free following surgery of the primary tumour, but remain at risk of developing either local or oligometastatic recurrence. Recurrence may be detected by imaging surveillance or clinically. Detection of recurrence is assumed to result in treatment that reduces the risk of further disease progression. Following oligometastasis, patients are at risk of polymetastases. Patients with polymetastases are assumed to die from causes related to sarcoma. Patients may die from causes unrelated to sarcoma prior to the development of polymetastases.

Fig. 1
figure1

Sarcoma model structure

The model represents the effects of alternative imaging-based surveillance pathways through the earlier detection of local and metastatic recurrence. Alternative forms of surveillance can be applied, including MRI (to detect local recurrence), CT scans (to detect metastatic recurrence) and PET scans (to detect both forms of recurrence). Patients with recurrence undergoing surveillance imaging move to a detected state (true positive imaging result) or move back to the same undetected state (false negative result). Patients without recurrence incur costs associated with further diagnostic tests if a false positive test result is returned.

Model inputs

Initial ranges for model input parameter values were estimated from published literature and consensus discussion between the clinical and health economist authors of the paper. These estimates were further explored and consolidated at Australia and New Zealand Sarcoma Association (ANZSA) Scientific Advisory Committee Meeting and were thought to be consistent with the latest literature. Valid (or convergent) combinations of input values for the clinical parameters (disease progression, imaging test characteristics and clinical presentation probabilities) were identified using a calibration process in which model outputs were compared with 5- and 10-year cumulative metastatic disease and mortality probabilities for the observed clinical cohort, were estimated using the Sarculator® (stratified prognosis of patients with high-risk STS) tool based on the baseline characteristics of the observed patient cohort [33].

The calibration process involved sampling sets of input parameter values from ranges for each clinical input parameter, which were based on literature. The cost-effectiveness model was run for each sampled set of parameter values, following 2000 hypothetical ‘patients’ from the time of diagnosis to the time of death. Each of the 2000 hypothetical patients was randomly assigned the baseline characteristics of one of the 133 patients in the observed cohort of patients, including the sampled patient’s observed surveillance pathway (i.e. the timing and type of surveillance received).

A sampled set of input parameter values was defined as convergent if the model predicted 5- and 10-year cumulative metastatic disease and mortality probabilities that were within the 95% confidence interval of the observed values. Calibration continued until 1000 sets of convergent input parameters were identified (Table 1) [28, 34,35,36,37,38,39].

Table 1 Parameter values

Model analysis

The calibration model was adapted to apply cost and health-related quality of life (utility) weights to events experienced within the model (Table 2) [40]. The cost parameters were based on consultations, tests and procedures associated with each health state, as defined by the clinical authors, to which Medicare Benefits Schedule (MBS) item numbers were applied [41]. The utility input parameter values were derived from the published literature [32, 41]. The cost estimation of surgical procedures for recurrence did not take into account for post-operative complications and other ancillary costs such as rehabilitation.

Table 2 Utility cost and value

The final model was set-up to analyse a non-imaging (‘baseline surveillance’) option and three surveillance imaging strategies (MRI, CT and PET). The same imaging pathway was applied to all three imaging options: each 3 months for 2 years post-primary treatment, followed by 6 months until 5 years post-primary treatment, followed by annual imaging beyond 5 years.

For each of the evaluated surveillance scenarios, the same generated cohort of 2000 ‘patients’ was run through the model for each of the 1000 sampled sets of convergent input parameter values. The model time horizon was the remaining lifetime of the patient cohorts. Model outputs included discounted costs (health state costs, costs of surveillance and total costs), the percentage of ‘patients’ dying due to sarcoma, undiscounted life expectancy and discounted QALYs. Costs and QALYs were discounted at 5% per annum.

Two scenario analyses were undertaken with respect to the cost and utility input parameter values. In the analysis designed to favour surveillance options that only detect metastatic disease, costs associated with detected local recurrence and metastatic disease are increased and decreased by 25%, respectively, and the utility differences between the disease-free state and detected local recurrence and metastatic disease are decreased and increased by 50%, respectively. In the analysis designed to favour strategies that detect both local recurrence and metastatic disease, the opposite increases and decreases are applied to the cost and utility values.

Mean incremental cost-effectiveness ratios (ICERs) were estimated between the alternative surveillance imaging strategies. A probabilistic sensitivity analysis generated probabilities that each strategy is most cost-effective at alternative assumed monetary values for the gain of additional QALYs.

Results

Baseline characteristics of patient population and treatments received are summarised in Table 3.

Table 3 Baseline characteristics of final study cohort

Surveillance imaging frequency and modality (observed patient cohort)

Three-monthly chest imaging was the most commonly adopted follow-up frequency in the first 2 years (n = 53, 46%). The rest were followed up between 4 and 6 monthly. Of 127 patients who commenced surveillance imaging, 86% (n = 110) were imaged with CT scan. Twelve patients (9%) underwent alternating chest X-ray and CT chest. Only three patients were followed up with chest X-ray alone. Two patients had no chest surveillance.

MRI was used to follow-up the primary site in 62% of patients (n = 79) at a variable time intervals between 3 and 6 months in the first 2 years. Ultrasound and CT scan were used sporadically to detect local recurrence in seven and three patients respectively. Twenty-six patients had PET-CT alone at least once during their surveillance period (20%). Overall, there was no consistent practice among clinicians or across the three institutions with regards to imaging frequency and modality.

Treatment outcomes (observed patient cohort)

40 patients (30%) developed disease recurrence after a median follow-up of 29.9 months (range 0.3–67.7 months). 12.0% (n = 16) had local recurrence alone, 21.1% (n = 28) had distant recurrence, with the majority developing pulmonary metastases alone (n = 22, 78.6%). Six patients (4.5%) had both local and distant recurrences.

Cost-effectiveness analysis

The cost-effectiveness model simulated the health service costs and QALYs that would be experienced by the observed cohort of patients with high-grade STS, for alternative surveillance strategies (Table 4). In the base case (no surveillance), the model predicted that 49% of the cohort is expected to die as a result of developing polymetastatic disease. Mean, undiscounted life expectancy across the whole cohort was 19.6 years. Discounted at 5% per annum, the expected mean QALY gain is 7.5 QALYs and expected costs related to the treatment of sarcoma are $42,483 per patient.

Table 4 Base case results

CT screening was the least costly surveillance strategy, costing an expected $4032 per patient over their remaining lifetime. As a result of CT surveillance and earlier detection of metastatic disease, the costs of treating sarcoma recurrence and progression increased slightly to $44,357 to generate an aggregate lifetime cost per patient of $48,389. The CT alone strategy had an expected increment of 0.19 QALYs per patient, which generated an incremental cost per QALY gained of $30,743 per QALY gained compared to a no surveillance strategy.

Adding MRI to CT screening increased surveillance costs significantly, to $10,654 per patient. QALY gains increased to 7.76, an incremental gain of 0.07 QALYs, which resulted in an incremental cost per QALY gained of $96,556 compared to 6 monthly CT screening alone.

PET-CT surveillance has a theoretical advantage of enabling early detection of both local recurrence and metastatic disease with a single imaging modality, but it was marginally less effective than the combined CT + MRI option. It was also significantly most costly, which resulted in PET-CT being dominated (costing more and gaining fewer QALYs) by the CT + MRI option.

The results of the scenario analyses show that the use of cost and utility values that are more favourable to strategies that only detect metastatic disease decreased the ICERs associated with the CT screening options, with the more frequent CT screening option becoming the most cost-effective strategy (Table 5). In the scenario analysis favouring options able to detect both local recurrence and metastatic disease, the ICER for low frequency CT surveillance increases significantly to over $75,000 per QALY gained. The ICER for higher versus lower frequency CT surveillance decreases, but the ICER for the ICER for higher frequency CT surveillance versus no surveillance increases to almost $50,000 per QALY gained. The CT + MRI strategy becomes more attractive, whilst PET remains a dominated strategy.

Table 5 One-way sensitivity analysis

The outputs from a probabilistic sensitivity analysis are presented in the form of a cost-effectiveness acceptability curve in Fig. 2, which shows that both MRI and PET-CT strategies have a zero probability of being cost-effective no matter what monetary value is attached to the gain of additional QALYs. At a monetary value of $30,000 per QALY gained, the probability of CT surveillance being cost-effective is 49%, and at $50,000 the probability is around 82%. Beyond $50,000, the probability of CT + MRI being cost-effective starts to rise, reaching a probability of 49% at a monetary value of $100,000 per QALY gained.

Fig. 2
figure2

Cost-effectiveness acceptability curves

Figure 3 presents the results of the probabilistic sensitivity analysis in the form of a cost-effectiveness plane, which shows the separation of the cost differences (to a no surveillance option) and the overlapping QALY differences between the surveillance options.

Fig. 3
figure3

Cost-effectiveness plane

Discussion

Evidence for surveillance following primary soft tissue sarcoma treatment is scarce and survival benefits and cost-effectiveness has not been established [8, 42, 43]. The purpose of surveillance imaging is to detect disease recurrence early enough to allow for curative intervention and reduced disease-specific mortality. Current surveillance practices are widely variable and existing guidelines from the National Comprehensive Cancer Network and the European Society for Medical Oncology are based on expert consensus [3, 13]. (Table 6).

Table 6 Differences in recommended surveillance imaging between NCCN and ESMO guidelines

Variability in frequency and modality of follow-up is widely reported in the literature. A literature review by Goel et al. identified 54 different surveillance strategies of 5-year surveillance protocols for postoperative, low- to high-grade extremity STS covering years 1982 to 2003 in 34 published studies [29]. Clinical examination and chest X-ray were the most commonly used methods. Our study showed marked variability in post-operative surveillance across three Australian sarcoma services and between sarcoma specialists, however with infrequent use of chest X-ray. This may reflect easier access to more sophisticated imaging in Australia including the prevalent use of CT-PET.

High quality evidence to guide optimal surveillance is limited. Increased frequency of surveillance may lead to earlier detection of local or distant recurrence and improved survival. However, increased frequency also increases cost and may not be the most effective use of resources. Evidence for survival benefit for early detection of recurrence is lacking [5, 44]. The only available randomised study comes from a large Indian specialist cancer centre, where 500 non-metastatic sarcoma patients were randomised to four different surveillance protocols to determine non-inferiority of chest X-ray to CT scan and of less frequent (6-monthly) to more frequent (3-monthly) group [45]. In the updated analysis with a median follow up of 81 months, Puri et al. concluded that less intensive follow-up regimen with chest X-ray at 6-monthly intervals and patient education regarding self-examination of the primary sarcoma site detected the majority of distant and local recurrences without deleterious effects on overall survival [25]. The role of chest X-ray and physical examination should be explored in the Australian setting as adequate modality of surveillance.

Similar to our study design, Royce et al. used a computer simulation model to analyse the most cost-effective surveillance strategy for distant recurrence in a stage II and III extremity STS cohort [31]. Four different surveillance strategies were assessed, including ‘watchful waiting’ with no imaging, chest X-ray, CT chest or PET/CT. They concluded that optimal surveillance should be individualised based on patients’ risks for disease recurrence with CT chest as a preferred modality for imaging high-risk patients for distant recurrence and chest X-ray or CT chest at a less frequent interval as a preferred option for low-risk patients.

Our study has several limitations worth noting. Firstly, the model is based on a small number of patients from heterogeneous population of soft tissue sarcomas from three selected sarcoma referral centres. Given the rarity of individual sarcoma histology subtype, heterogeneity inevitably complicates studies of this disease group. In addition, chest X-ray was not included as a surveillance option due to low utilisation in our patient population and physical examination as a modality to detect local recurrence was not explored in this analysis, rather we concentrated more on the use of surveillance imaging. Despite these limitations this study is the first of its kind reflecting on the ‘real-world’ practice in the Australian setting and utilising patient data to generate a computer simulation model.

The soaring cost of health care is a well-recognised problem worldwide. Surveillance following primary cancer treatment must balance gains in survival with societal willingness to expend health care resources and cost effectiveness. Our study suggests that CT surveillance of chest is the most cost-effective surveillance option and frequent use of MRI and PET is not supported by its significant cost burden.

Conclusions

This study confirms wide variation in surveillance practices amongst Australian sarcoma specialists within the high-risk STS cohort. Relatively intense imaging follow-up strategies were practiced at Australian sarcoma referral centres. For patients with high-risk extremity STS, more frequent surveillance for distant disease recurrence with CT scan appears cost-effective at an acceptable gain in QALY. Further work is required to evaluate cost-effectiveness in a prospective manner and to stratify surveillance against risk.

Availability of data and materials

The datasets used for the analysis in the study can be made available from the corresponding author upon reasonable request.

Abbreviations

AJCC:

American Joint Committee on Cancer

ANZSA:

Australia and New Zealand Sarcoma Association

CT:

Computed tomography

ICER:

Incremental cost-effectiveness ratios

MRI:

Magnetic resonance imaging

MBS:

Medicare Benefits Schedule

QALY:

Quality adjusted life years

PET:

Position emission tomography

STS:

Soft tissue sarcomas

References

  1. 1.

    Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin. 2010;60(5):277–300.

    PubMed  Article  Google Scholar 

  2. 2.

    Bessen T, Caughey GE, Shakib S, Potter JA, Reid J, Farshid G, et al. A population-based study of soft tissue sarcoma incidence and survival in Australia: an analysis of 26,970 cases. Cancer Epidemiol. 2019;63:101590.

    PubMed  Article  Google Scholar 

  3. 3.

    National Comprehensive Cancer Network. Soft Tissue Sarcoma (Version 1.2018). http://nlmsf.org/wp-content/uploads/2018/03/NCCNsarcoma-guidelines-for-physicians.pdf. Accessed 1 Dec 2018.

  4. 4.

    Chou YS, Liu CY, Chen WM, Chen TH, Chen PC, Wu HT, et al. Follow-up after primary treatment of soft tissue sarcoma of extremities: impact of frequency of follow-up imaging on disease-specific survival. J Surg Oncol. 2012;106(2):155–61.

    PubMed  Article  Google Scholar 

  5. 5.

    Stojadinovic A, Yeh A, Brennan MF. Completely resected recurrent soft tissue sarcoma: primary anatomic site governs outcomes. J Am Coll Surg. 2002;194(4):436–47.

    PubMed  Article  Google Scholar 

  6. 6.

    Smith R, Pak Y, Kraybill W, Kane JM 3rd. Factors associated with actual long-term survival following soft tissue sarcoma pulmonary metastasectomy. Eur J Surg Oncol. 2009;35(4):356–61.

    CAS  PubMed  Article  Google Scholar 

  7. 7.

    Rehders A, Hosch SB, Scheunemann P, Stoecklein NH, Knoefel WT, Peiper M. Benefit of surgical treatment of lung metastasis in soft tissue sarcoma. Arch Surg. 2007;142(1):70–5 (discission 6).

    PubMed  Article  Google Scholar 

  8. 8.

    Okiror L, Peleki A, Moffat D, Bille A, Bishay E, Rajesh P, et al. Survival following pulmonary metastasectomy for sarcoma. Thorac Cardiovasc Surg. 2016;64(2):146–9.

    PubMed  Article  Google Scholar 

  9. 9.

    Casson AG, Putnam JB, Natarajan G, Johnston DA, Mountain C, McMurtrey M, et al. Five-year survival after pulmonary metastasectomy for adult soft tissue sarcoma. Cancer. 1992;69(3):662–8.

    CAS  PubMed  Article  PubMed Central  Google Scholar 

  10. 10.

    Garcia Franco CE, Algarra SM, Ezcurra AT, Guillen-Grima F, San-Julian M, Mindan JP, et al. Long-term results after resection for soft tissue sarcoma pulmonary metastases. Interact Cardiovasc Thorac Surg. 2009;9(2):223–6.

    PubMed  Article  Google Scholar 

  11. 11.

    Predina JD, Puc MM, Bergey MR, Sonnad SS, Kucharczuk JC, Staddon A, et al. Improved survival after pulmonary metastasectomy for soft tissue sarcoma. J Thorac Oncol. 2011;6(5):913–9.

    PubMed  Article  Google Scholar 

  12. 12.

    Grimer R, Judson I, Peake D, Seddon B. Guidelines for the management of soft tissue sarcomas. Sarcoma. 2010;2010:506182.

    PubMed  PubMed Central  Google Scholar 

  13. 13.

    Casali PG, Abecassis N, Aro HT, Bauer S, Biagini R, Bielack S, et al. Soft tissue and visceral sarcomas: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2018;29(Supplement_4):iv268–9.

    CAS  PubMed  Article  Google Scholar 

  14. 14.

    Beitler AL, Virgo KS, Johnson FE, Gibbs JF, Kraybill WG. Current follow-up strategies after potentially curative resection of extremity sarcomas: results of a survey of the members of the society of surgical oncology. Cancer. 2000;88(4):777–85.

    CAS  PubMed  Article  Google Scholar 

  15. 15.

    Greenberg DD, Crawford B. Surveillance strategies for sarcoma: results of a survey of members of the musculoskeletal tumor society. Sarcoma. 2016;2016:8289509.

    PubMed  PubMed Central  Article  Google Scholar 

  16. 16.

    Gerrand CH, Billingham LJ, Woll PJ, Grimer RJ. Follow up after Primary treatment of soft tissue sarcoma: a survey of current practice in the United Kingdom. Sarcoma. 2007;2007:34128.

    CAS  PubMed  PubMed Central  Article  Google Scholar 

  17. 17.

    Gonzalez A, Mahesh M, Kim KP, Bhargavan M, Lewis R, Mettler F, et al. Projected cancer risks from computed tomographic scans performed in the United States in 2007. Arch Intern Med. 2009;169(22):2071–7.

    PubMed Central  Article  PubMed  Google Scholar 

  18. 18.

    Brenner DJ, Hall EJ. Computed tomography—an increasing source of radiation exposure. N Engl J Med. 2007;357(22):2277–84.

    CAS  PubMed  PubMed Central  Article  Google Scholar 

  19. 19.

    Hovgaard TB, Nymark T, Skov O, Petersen MM. Follow-up after initial surgical treatment of soft tissue sarcomas in the extremities and trunk wall. Acta Oncol. 2017;56(7):1004–12.

    PubMed  Article  PubMed Central  Google Scholar 

  20. 20.

    Kane JM 3rd. Surveillance strategies for patients following surgical resection of soft tissue sarcomas. Curr Opin Oncol. 2004;16(4):328–32.

    PubMed  Article  PubMed Central  Google Scholar 

  21. 21.

    Patel SR, Zagars GK, Pisters PW. The follow-up of adult soft-tissue sarcomas. Semin Oncol. 2003;30(3):413–6.

    PubMed  Article  PubMed Central  Google Scholar 

  22. 22.

    Rothermundt C, Whelan JS, Dileo P, Strauss SJ, Coleman J, Briggs TW, et al. What is the role of routine follow-up for localised limb soft tissue sarcomas? A retrospective analysis of 174 patients. Br J Cancer. 2014;110(10):2420–6.

    CAS  PubMed  PubMed Central  Article  Google Scholar 

  23. 23.

    Whooley BP, Mooney MM, Gibbs JF, Kraybill WG. Effective follow-up strategies in soft tissue sarcoma. Semin Surg Oncol. 1999;17(1):83–7.

    CAS  PubMed  Article  PubMed Central  Google Scholar 

  24. 24.

    Cheney MD, Giraud C, Goldberg SI, Rosenthal DI, Hornicek FJ, Choy E, et al. MRI surveillance following treatment of extremity soft tissue sarcoma. J Surg Oncol. 2014;109(6):593–6.

    PubMed  Article  PubMed Central  Google Scholar 

  25. 25.

    Puri A, Ranganathan P, Gulia A, Crasto S, Hawaldar R, Badwe RA. Does a less intensive surveillance protocol affect the survival of patients after treatment of a sarcoma of the limb? updated results of the randomized TOSS study. Bone Joint J. 2018;100-B(2):262–8.

    CAS  PubMed  Article  PubMed Central  Google Scholar 

  26. 26.

    Watts AC, Teoh K, Evans T, Beggs I, Robb J, Porter D. MRI surveillance after resection for primary musculoskeletal sarcoma. J Bone Joint Surg Br. 2008;90(4):484–7.

    CAS  PubMed  Article  PubMed Central  Google Scholar 

  27. 27.

    Ezuddin NS, Pretell-Mazzini J, Yechieli RL, Kerr DA, Wilky BA, Subhawong TK. Local recurrence of soft-tissue sarcoma: issues in imaging surveillance strategy. Skeletal Radiol. 2018;47(12):1595–606.

    PubMed  Article  PubMed Central  Google Scholar 

  28. 28.

    Whooley BP, Gibbs JF, Mooney MM, McGrath BE, Kraybill WG. Primary extremity sarcoma: what is the appropriate follow-up? Ann Surg Oncol. 2000;7(1):9–14.

    CAS  PubMed  Article  PubMed Central  Google Scholar 

  29. 29.

    Goel A, Christy ME, Virgo KS, Kraybill WG, Johnson FE. Costs of follow-up after potentially curative treatment for extremity soft-tissue sarcoma. Int J Oncol. 2004;25(2):429–35.

    PubMed  PubMed Central  Google Scholar 

  30. 30.

    Patel SA, Royce TJ, Barysauskas CM, Thornton KA, Raut CP, Baldini EH. Surveillance imaging patterns and outcomes following radiation therapy and radical resection for localized extremity and trunk soft tissue sarcoma. Ann Surg Oncol. 2017;24(6):1588–95.

    PubMed  Article  Google Scholar 

  31. 31.

    Royce TJ, Punglia RS, Chen AB, Patel SA, Thornton KA, Raut CP, et al. Cost-effectiveness of surveillance for distant recurrence in extremity soft tissue sarcoma. Ann Surg Oncol. 2017;24(11):3264–70.

    PubMed  Article  Google Scholar 

  32. 32.

    Bessen T, Karnon J. A patient-level calibration framework for evaluating surveillance strategies: a case study of mammographic follow-up after early breast cancer. Value Health. 2014;17(6):669–78.

    PubMed  Article  Google Scholar 

  33. 33.

    Frezza AM, Stacchiotti S, Gronchi A. Highlights in soft tissue sarcomas and gastrointestinal stromal tumours (GIST) trials reported at ASCO 2017 Annual Meeting. BMC Med. 2017;15(1):160.

    PubMed  PubMed Central  Article  CAS  Google Scholar 

  34. 34.

    Guadagnolo BA, Zagars GK, Ballo MT, Patel SR, Lewis VO, Pisters PW, et al. Long-term outcomes for synovial sarcoma treated with conservation surgery and radiotherapy. Int J Radiat Oncol Biol Phys. 2007;69(4):1173–80.

    PubMed  Article  Google Scholar 

  35. 35.

    Daigeler A, Zmarsly I, Hirsch T, Goertz O, Steinau HU, Lehnhardt M, et al. Long-term outcome after local recurrence of soft tissue sarcoma: a retrospective analysis of factors predictive of survival in 135 patients with locally recurrent soft tissue sarcoma. Br J Cancer. 2014;110(6):1456–64.

    CAS  PubMed  PubMed Central  Article  Google Scholar 

  36. 36.

    Welter S, Grabellus F, Bauer S, Schuler M, Eberhardt W, Totsch M, et al. Growth patterns of lung metastases from sarcoma: prognostic and surgical implications from histology. Interact Cardiovasc Thorac Surg. 2012;15(4):612–7.

    PubMed  PubMed Central  Article  Google Scholar 

  37. 37.

    Christie-Large M, James SL, Tiessen L, Davies AM, Grimer RJ. Imaging strategy for detecting lung metastases at presentation in patients with soft tissue sarcomas. Eur J Cancer. 2008;44(13):1841–5.

    CAS  PubMed  Article  Google Scholar 

  38. 38.

    Park SY, Chung HW, Chae SY, Lee JS. Comparison of MRI and PET-CT in detecting the loco-regional recurrence of soft tissue sarcomas during surveillance. Skelet Radiol. 2016;45(10):1375–84.

    Article  Google Scholar 

  39. 39.

    Bastiaannet E, Groen H, Jager PL, Cobben DC, van der Graaf WT, Vaalburg W, et al. The value of FDG-PET in the detection, grading and response to therapy of soft tissue and bone sarcomas; a systematic review and meta-analysis. Cancer Treat Rev. 2004;30(1):83–101.

    CAS  PubMed  Article  Google Scholar 

  40. 40.

    Jonsson L, Justo N, Musayev A, Krishna A, Burke T, Pellissier J, et al. Cost of treatment in patients with metastatic soft tissue sarcoma who respond favourably to chemotherpy. The SArcoma treatment and Burden of Illness in North America and Europe (SABINE) study. Eur J Cancer Care (Engl). 2016;25(3):466–77.

    CAS  Article  Google Scholar 

  41. 41.

    Australian Government Department of Health. Medicare benefits schedule online. 2018. https://mbsonline.gov.au. Accessed 18 Nov 2018.

  42. 42.

    Cho HS, Park IH, Jeong WJ, Han I, Kim HS. Prognostic value of computed tomography for monitoring pulmonary metastases in soft tissue sarcoma patients after surgical management: a retrospective cohort study. Ann Surg Oncol. 2011;18(12):3392–8.

    PubMed  Article  PubMed Central  Google Scholar 

  43. 43.

    Tseng WW, Amini B, Madewell JE. Follow-up of the soft tissue sarcoma patient. J Surg Oncol. 2015;111(5):641–5.

    PubMed  Article  PubMed Central  Google Scholar 

  44. 44.

    Trovik CS, Gustafson P, Bauer HC, Saeter G, Klepp R, Berlin O, et al. Consequences of local recurrence of soft tissue sarcoma: 205 patients from the Scandinavian Sarcoma Group Register. Acta Orthop Scand. 2000;71(5):488–95.

    CAS  PubMed  Article  PubMed Central  Google Scholar 

  45. 45.

    Puri A, Gulia A, Hawaldar R, Ranganathan P, Badwe RA. Does intensity of surveillance affect survival after surgery for sarcomas? Results of a randomized noninferiority trial. Clin Orthop Relat Res. 2014;472(5):1568–75.

    PubMed  Article  PubMed Central  Google Scholar 

Download references

Acknowledgements

We acknowledge the contribution of data collection by data managers at each institution (Jasmine Mar, Sonya Stephens, Jessica Reid, and Diane Schipp).

Funding

This work was supported by a grant provided by the Ursini Foundation via the Australia & New Zealand Sarcoma Association (ANZSA). BioGrid Australia provided the data linkage support (Grant ID 25/2013).

Author information

Affiliations

Authors

Contributions

The first author contributed from the audit through to manuscript submission with design, statistical and editorial input from the rest of the co-authors. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Susie Bae.

Ethics declarations

Ethics approval and consent to participate

This study was approved by the Human Research Ethics Committee at Peter MacCallum Cancer Centre, Royal Adelaide Hospital and Prince of Wales Hospital. The need for individual patient consent was waived based on low risk to participants.

Consent for publication

Not applicable, as the manuscript does not contain any individual person’s data.

Competing interests

The authors declare that they have no competing interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Bae, S., Karnon, J., Crane, G. et al. Cost-effectiveness analysis of imaging surveillance in stage II and III extremity soft tissue sarcoma: an Australian perspective. Cost Eff Resour Alloc 18, 5 (2020). https://doi.org/10.1186/s12962-020-0202-7

Download citation

Keywords

  • Soft tissue sarcoma
  • Cost-effectiveness
  • Imaging surveillance
  • Disease recurrence
  • Local recurrence
  • Distant recurrence
  • Pulmonary metastases
  • Metastasectomy