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Table 1 Results of the systematic literature review regarding median OS

From: Cost-benefit evaluation of advanced therapy lines in metastatic triple-negative breast cancer in Germany

Authors

Title

Year

Journal

Intervention

Population [n]

Median OS

Bardia, A. et al. [6]

Sacituzumab Govitecan in Metastatic Triple-Negative Breast Cancer

2021

N Engl J Med

SG

267

11.8 months

Bardia, A. et al. [26]

Efficacy and Safety of Anti-Trop-2 Antibody Drug Conjugate Sacituzumab Govitecan (IMMU-132) in Heavily Pretreated Patients With Metastatic Triple-Negative Breast Cancer

2017

J Clin Oncol

SG

69

16.6 months

Sari, M. et al. [36]

Eribulin monotherapy in heavily pretreated metastatic breast cancer patients in real life

2020

Indian J Cancer

Eribulin

7

10 months

Krasniqi, E. et al. [27]

Second-line Eribulin in Triple Negative Metastatic Breast Cancer patients. Multicentre Retrospective Study: The TETRIS Trial

2021

Int J Med Sci

Eribulin

44

11.9 months

Kazmi, S. et al. [28]

Overall survival analysis in patients with metastatic breast cancer and liver or lung metastases treated with eribulin, gemcitabine, or capecitabine

2020

Breast Cancer Res Treat

Eribulin Capecitabine

66 (Eribulin)

20 (Capecitabine)

7.0 months (Eribulin)

5.5 months (Capecitabine)

Ates, O. et al. [37]

Efficacy and safety of eribulin monotherapy in patients with heavily pretreated metastatic breast cancer

2016

J BUON

Eribulin

7

3 months

Mougalian, SS. et al. [29]

Clinical benefit of treatment with eribulin mesylate for metastatic triple-negative breast cancer: Long-term outcomes of patients treated in the US community oncology setting

2018

Cancer Med

Eribulin

127

14.7 months

Miyoshi, Y. et al. [30]

High absolute lymphocyte counts are associated with longer overall survival in patients with metastatic breast cancer treated with eribulin-but not with treatment of physician’s choice-in the EMBRACE study

2020

Breast Cancer

Eribulin

27

65*

9.5 months

9.5 months**

Valerio, M.R. et al. [31]

Eribulin Mesylate for the Treatment of Metastatic Hormone-refractory and Triple-negative Breast Cancer: A Multi-institutional Real-world Report on Efficacy and Safety

2021

Am J Clin Oncol

Eribulin

38

10.8 months

Decker, T. et al. [39]

VicTORia: a randomised phase II study to compare vinorelbine in combination with the mTOR inhibitor everolimus versus vinorelbine monotherapy for second-line chemotherapy in advanced HER2-negative breast cancer

2019

Breast Cancer Res Treat

Vinorelbine

12

9.44 months

Pedersini, R. et al. [38]

Eribulin in Heavily Pretreated Metastatic Breast Cancer Patients in the Real World: A Retrospective Study

2018

Oncology

Eribulin

8

7.43 months

Aogi, K. et al. [32]

A phase II study of eribulin in Japanese patients with heavily pretreated metastatic breast cancer

2012

Ann Oncol

Eribulin

22

10.68 months

Mougalian, SS. et al. [33]

Effectiveness of Eribulin in Metastatic Breast Cancer: 10 Years of Real-World Clinical Experience in the United States

2021

Adv Ther

Eribulin

256

9.8 months

Twelves, C. et al. [34]

Subgroup Analyses from a Phase 3, Open-Label, Randomized Study of Eribulin Mesylate Versus Capecitabine in Pretreated Patients with Advanced or Metastatic Breast Cancer

2016

Breast Cancer (Auckl)

Eribulin

Capecitabine

106 (Eribulin)

102 (Capecitabine)

15.2 months (Eribulin)

9.2 months (Capecitabine)

Chan, A. et al. [35]

Incorporation of eribulin in the systemic treatment of metastatic breast cancer patients in Australia

2022

Asia Pac J Clin Oncol.

Eribulin

51***

4.3 months

  1. * Two arms received eribulin
  2. ** We included the average into the efficiency frontier calculation
  3. *** Number of total TNBC population, the exact number of patients evaluated for late-use not provided