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Table 3 Budget impact analysis results

From: Cost-effectiveness and budget impact analysis of Daratumumab, Lenalidomide and dexamethasone for relapsed-refractory multiple myeloma

Year

2022

2023

2024

2025

2026

Iran population

85,345,667

86,369,815

87,406,253

88,455,128

89,516,589

Number of patients of MM

4267

4318

4370

4423

4476

Number of patients of MM with adjusted death rate

3456

3498

3540

3582

3625

Total number of MM who deserve to receive DRd or KRd

691

700

708

716

725

KRD market share

0.95

0.9

0.85

0.8

0.75

Daratumumab market share

0.05

0.1

0.15

0.2

0.25

Scenario 1 (without DRd)

10,258,397

10,381,497

10,506,457

10,632,438

10,759,734

Scenario 2 (with DRd)

10,656,889

11,188,046

11,730,407

12,284,193

12,849,570

Financial impact

398,492

806,549

1,223,950

1,651,755

2,089,836

Financial impact%

3%

7%

12%

16%

19%

  1. DRd, Daratumumab, Lenalidomide, dexamethasone, KRd Carfilzomib, Lenalidomide, dexamethasone