Table 2 Cost parameters input in the model

Nivolumab (100 mg)

1342.11 (China)

1073.69-1610.53

Local estimate

Gamma

3290.22 (US)

2632.18-3948.26

RED BOOK

Gamma

Nivolumab (40 mg)

665.40 (China)

532.32-798.48

Local estimate

Gamma

1316.09 (US)

1052.87-1579.31

RED BOOK

Gamma

Oxaliplatin (50 mg)

164.50 (China)

131.60-197.40

Local estimate

Gamma

98.88(US)

79.10-118.66

RED BOOK

Gamma

Capecitabine (500 mg)

1.76 (China)

1.41–2.11

Local estimate

Gamma

37.71 (US)

30.17–45.25

RED BOOK

Gamma

5-Fu (250 mg)

7.61 (China)

6.09–9.13

Local estimate

Gamma

59.85 (US)

47.88–71.82

RED BOOK

Gamma

Leucovorin (100 mg)

2.22 (China)

1.78–2.66

Local estimate

Gamma

22.8 (US)

18.24–27.36

RED BOOK

Gamma

Paclitaxel (30 mg)

59.25 (China)

47.40–71.10

Local estimate

Gamma

20.16 (US)

16.13–24.19

RED BOOK

Gamma

Docetaxel (20 mg)

162.18 (China)

129.74-194.62

Local estimate

Gamma

211.14 (US)

168.91-253.37

RED BOOK

Gamma

Carboplatin (50 mg)

4.40 (China)

3.52–5.28

Local estimate

Gamma

12.29 (US)

9.83–14.75

RED BOOK

Gamma

Cisplatin (30 mg)

2.78 (China)

2.22–3.34

Local estimate

Gamma

21.20 (US)

16.96–25.44

RED BOOK

Gamma

Ramucirumab (100 mg)

-

Local estimate

Gamma

1427.58 (US)

1142.06-1713.10

RED BOOK

Gamma

Perbrolizumab (100 mg)

2596.96 (China)

2077.57-3116.35

Local estimate

Gamma

5834.45 (US)

4667.56-7001.34

RED BOOK

Gamma

Toripalimab (2400 mg)

304. 51 (China)

243.61-365.41

Local estimate

Gamma

-

-

RED BOOK

Gamma

Atezolizumab (1200 mg)

4753.90 (China)

3803.12-5704.68

Local estimate

Gamma

11032.84 (US)

8826.27-13239.41

RED BOOK

Gamma

Ipilimumab (50 mg)

4058.21 (China)

3246.57-4869.85

Local estimate

Gamma

9273.77 (US)

7419.02-11128.52

RED BOOK

Gamma

Laboratory tests

28.99 (China)

23.19–34.79

Local estimate

Gamma

315 (US)

252–378

[17]

Gamma

CT

289.73 (China)

231.78-347.68

Local estimate

Gamma

231 (US)

184.8-277.2

[17]

Gamma

Anemia

508.2 (China)

406.56-609.84

[15]

Gamma

4368 (US)

3494.4-5241.6

[19]

Gamma

Neutropenia

466 (China)

372.8-559.2

[15]

Gamma

5937 (US)

4749.6-7124.4

[18]

Gamma

Neutrophil count decreased

534.4 (China)

427.52-641.28

[16]

Gamma

5937 (US)

4749.6-7124.4

[18]

Gamma

Cost of supportive

care per cycle

117 (China)

93.6-140.4

[17]

Gamma

3049 (US)

2439.2-3658.8

[17]

Gamma

Routine follow-up of patients per unit

51.5 (China)

41.2–61.8

[17]

Gamma

422 (US)

337.6-506.4

[19]

Gamma