Table 3 Summary of additional deterministic scenario analyses
Scenario | Incremental LYs | Incremental QALYs | Incremental costs | ICER |
|---|---|---|---|---|
Deterministic base case | 0.86 | 0.80 | SGD 540 | SGD 677/QALY |
Discount rate (0%) | 1.63 | 1.41 | SGD 4842 | SGD 3446/QALY |
Discount rate (5%) | 0.59 | 0.58 | SGD 32 | SGD 55/QALY |
Time horizon 30 years | 0.69 | 0.68 | − SGD 2888 | Dominant |
Time horizon 50 years | 0.95 | 0.86 | SGD 2726 | SGD 3168/QALY |
OS HR approach | 0.72 | 0.70 | SGD 4605 | SGD 6593/QALY |
OS combined fit alternate curve | 0.64 | 0.63 | − SGD 16,250 | Dominant |
DoT KM individual treatments | 0.86 | 0.80 | − SGD 31,454 | Dominant |
DoT KM by treatment arm | 0.86 | 0.80 | − SGD 33,187 | Dominant |
DoT KM then extrapolated by response | 0.86 | 0.80 | SGD 13,876 | SGD 17,370/QALY |
DoR alternative curve | 0.86 | 0.70 | SGD 49,472 | SGD 70,758/QALY |
Societal perspective | 0.86 | 0.80 | − SGD 27,960 | Dominant |
Age-adjusted utilities: regression equation | 0.86 | 0.73 | SGD 540 | SGD 739/QALY |
Age-adjusted utilities: Gen pop age category | 0.86 | 0.81 | SGD 540 | SGD 669/QALY |
Single comparator: ECP | 0.70 | 0.68 | − SGD 82,391 | Dominant |
Single comparator: MMF | 0.72 | 0.70 | SGD 63,741 | SGD 91,199/QALY |
Single comparator: MTX | 1.02 | 0.91 | SGD 76,198 | SGD 83,448/QALY |
BAT distribution based on informal physician survey | 0.86 | 0.80 | SGD 11,459 | SGD 14,344/QALY |
REACH3 BAT distribution | 0.86 | 0.80 | SGD 29,764 | SGD 37,259/QALY |
Include concomitant medicines | 0.86 | 0.80 | SGD 535 | SGD 670/QALY |
Include terminal care costs | 0.86 | 0.80 | SGD 666 | SGD 833/QALY |
Drug costs only | 0.86 | 0.80 | SGD 11,229 | SGD 14,057/QALY |