Fig. 1

Schematic diagram of the Markov model used in this study for cost-effectiveness analysis. The arrows show the transition of patients into different health states during each model cycle. At disease baseline, patients first pass through six 28-day tunnel states to capture initial mortality. During these cycles, patients can either progress to the next tunnel state or move into the death state. At response assessment (day 168), patients were assigned into overall responder (ORR) or non-responder (NR) health states. During each subsequent 28-day cycle, patients in the ORR health state could either remain in the ORR health state, progress to the NR health state, or die. Similarly, patients in the NR health state could either remain in the same health state or die during each model cycle. ALT, alanine aminotransferase; cGVHD, chronic graft-versus-host disease; CMV, cytomegalovirus