Table 4 Deterministic sensitivity analysis (example of results for Brazil)

Main results (QALYs lost and total costs)

Vaccine efficacy (range ∓ 12%)

 QALYs lost*

3,650,818 to 3,650,818

2,371,905 to 2,366,092

Cost-saving

2,554,111 to 2,545,448

Cost-saving

2,231,568 to 2,231,313

Cost-saving

 Total costs

$14,899,414,477 to $14,899,414,477

$10,328,733,920 to $10,271,273,293

$10,292,861,063 to $10,209,303,909

$10,413,997,276 to $10,407,423,859

Vaccination cost per dose, including total vaccination costs (range ∓ 25%)

 QALYs lost*

3,650,818 to 3,650,818

2,368,674 to 2,368,674

Cost-saving

2,549,322 to 2,549,322

Cost-saving

2,231,441 to 2,231,441

Cost-saving

 Total costs

$14,899,414,477 to $14,899,414,477

$9,737,176,309 to $10,860,768,550

$9,793,338,127 to $10,704,273,833

$97,27,507,775 to $11,093,911,333

Vaccination coverage (range ∓ 25%)

 QALYs lost*

3,650,818 to 3,650,818

2,573,443 to 2,182,900

Cost-saving

2,726,390 to 2,389,756

Cost-saving

2,452,015 to 2,034,425

Cost-saving

 Total costs

$14,899,414,477 to $14,899,414,477

$10,152,618,903 to $10,549,018,547

$10,318,767,762 to $10,382,247,295

$10,114,708,594 to $10,757,417,545

Health event costs (range ∓ 25%)

 QALYs lost*

3,650,818 to 3,650,818

2,368,674 to 2,368,674

Cost-saving

2,549,322 to 2,549,322

Cost-saving

2,231,441 to 2,231,441

Cost-saving

 Total costs

$11,174,560,858 to $18,624,268,097

$8,286,025,443 to $12,311,919,417

$8,142,072,338 to $12,355,539,622

$8,491,233,945 to $12,330,185,164

Disease transmission (range ∓ 25%)

 QALYs lost*

2,312,737 to 4,856,134

1,400,574 to 3,093,737

Cost-saving

1,542,160 to 3,285,146

Cost-saving

1,290,504 to 2,951,926

Cost-saving

 Total costs

$7,667,170,115 to $21,085,912,835

$7,287,515,194 to $12,417,277,625

$7,163,837,041 to $13,021,191,154

$7,419,212,868 to $12,377,885,228

Vaccine immunity duration (range 270–365 days)

 QALYs lost*

3,650,818 to 3,650,818

2,386,808 to 2,357,638

Cost-saving

2,566,343 to 2,539,071

Cost-saving

2,249,817 to 2,220,215

Cost-saving

 Total costs

$14,899,414,477 to $14,899,414,477

$10,336,865,926 to $10,277,311,931

$10,307,730,018 to $10,216,440,444

$10,442,698,112 to $10,391,333,074