Table 2 Cost and utility parameters

Drug costs

Durvalumab (1 mg)

5.61

4.21

7.01

Gamma

[17]

Gemcitabine (1 g)

52.43

39.32

65.54

Gamma

[17]

Cisplatin (30 mg)

3.84

2.88

4.80

Gamma

[17]

Pembrolizumab (100 mg)

2777.98

2083.49

3472.48

Gamma

[17]

Dabrafenib (75 mg*120)

1718.70

1289.03

2148.37

Gamma

[17]

Trametinib (2 mg*30)

1718.60

1288.95

2148.25

Gamma

[17]

Paclitaxel for injection (100 mg)

108.22

81.16

135.27

Gamma

[17]

Calcium folinate injection (100 mg)

3.88

2.91

4.85

Gamma

[17]

Regorafenib (40 mg)

26.74

20.06

33.43

Gamma

[17]

Oxaliplatin (100 mg)

78.54

58.91

98.18

Gamma

[17]

Fluorouracil (500 mg)

8.11

6.08

10.14

Gamma

[17]

Terminal cost

4517.85

3388.39

5647.31

Gamma

[18]

Cost of adverse events

Durvalumab plus chemotherapy

603.87

452.90

754.84

Gamma

[14, 19,20,21,22]

Chemotherapy alone

591.20

443.40

739.00

Gamma

[14, 19,20,21,22]

Costs of laboratory tests and imaging

268.22

201.16

335.27

Gamma

Local

Utility values

Progression-free survival

0.9

0.675

1.125

Beta

[15]

Progressive disease

0.4

0.3

0.5

Beta

[15]

Discount rate

0.05

0.0375

0.0625

Beta

[12]