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Table 3 Results of one-way sensitivity analyses of selected parameters

From: A cost-effectiveness modeling study of treatment interventions for stage I to III esophageal squamous cell carcinoma

Parameters

Range

Preferred strategy*

Stage I

 Esophagectomy

  Complication**

0.119–0.35

EMR

  Dead

0.018–0.111

EMR (ICER of $34,768 for esophagectomy at 0.041)

  No recurrence to metastasis

0.002–0.0139

EMR (ICER of $24,377 for esophagectomy at 0.0109)

 EMR

  Complication**

0.030–0.069

EMR

  No recurrence to local recurrence

0.0076–0.0426

EMR (ICER of $532 for EMR vs EMR followed by ablation at 0.03389)

 EMR followed by ablation

  Complication**

0.068–0.222

EMR

  No recurrence to local recurrence

0.014–0.033

EMR

  Utility of stage I

0.66–0.71

EMR

  Utility stage II and III

0.74–0.78

EMR

  Utility stage IV

0.73–0.77

EMR

Stage II and III

 Esophagectomy

  Complication**

0.25–0.39

CRT followed by surgery

  Dead

0.0339–0.111

CRT followed by surgery

  No recurrence to dead

0–0.0905

At 0.0452, ICER of $3513 for esophagectomy vs CRT followed by surgery

 CRT followed by surgery

  Complication**

0.17–0.289

CRT followed by surgery (at 0.289, ICER of $2373)

  Dead

0.04–0.105

CRT followed by surgery (at 0.105, ICER of $2493)

 CRT

  Complication**

0.148–0.28

CRT followed by surgery

  Dead

0.024–0.058

CRT followed by surgery

  No recurrence to local recurrence

0.028–0.0528

CRT followed by surgery

  No recurrence to metastasis

0.0221–0.0139

CRT followed by surgery

  Utility stage II and III

0.74–0.78

CRT followed by surgery

  Utility stage IV

0.73–0.77

CRT followed by surgery

  1. *The sensitivity analysis is based on the QALY outcome, ICER reported per QALY
  2. **Complications included; for esophagectomy: pulmonary infection, heart failure, anastomotic leakage, severe arrhythmia, bleeding, wound infection, atelectasis, and acute respiratory distress syndrome. For EMR: bleeding, perforation, prolonger hospitalization, stenosis, and pneumonia. For EMR followed by ablation: strictures, bleeding, pain, and perforation. For CRT followed by surgery: anastomotic leakage, peritonitis, mediastinitis, esophagotracheal fistula, wound complication, and cardiac complication. For CRT: anastomotic leakage, pneumonia, cardiac arrhythmia, chyle leak, wound infection, and thromboembolic event