Table 3 Threshold analysis
Parameter description | Adolescents/adults | Child aged 6–12 |
|---|---|---|
Number of recurrent ATIs in 12Â months prior to treatment (base case 2.5) | 3.33 ATIs: intervention becomes dominant | No threshold. Intervention dominant in all scenarios |
Probability of ATI after intervention | No threshold | Intervention no longer dominates where probability of ATI rises to 0.118 |
Reducing the expected number of ATIs in the control group in any one cycle (base case 0.66) | No threshold | Intervention no longer dominates when expected number of ATIs falls to 0.52 |
Number of treatment cycles (base case 6) | No threshold | Intervention no longer dominates when 2 or fewer treatment cycles |
Cost of SilAtro-5-90 (base case €13 and €26 per cycle for children and adults) | Intervention becomes dominant when cost falls to €14.48 | Intervention no longer dominates when costs increase to €14.49 |