Scenario | Description |
---|---|
Scenario 1: LEAD study baseline cohort | Base case analysis repeated using baseline characteristics reported in the LEAD study |
Scenario 2: split between SHE1:SHE2 as 1:1 | Adjusted the proportion of hypoglycemia requiring (SHE2) versus not-requiring medical (SHE1) assistance to 1:1. In base case, the percentage of SHE2 is set as 11.8% of total hypoglycemia rate |
Scenario 3: efficacy adjusted | Assumed that the rates of severe hypoglycaemia were at the upper bound of the 95% CI of glargine U100 treatment and the lower bound of 95% CI of NPH treatment |
Scenario 4: PROcam risk equations | Repeated analysis using PROcam risk equations to predict outcomes |
Scenario 5: UKPDS 82 risk equations | Repeated analysis using UKPDS 82 risk equations to predict outcomes |