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Table 4 Mean costs and QALYs estimated by the model and sensitivity analyses

From: Decision uncertainty and value of further research: a case-study in fenestrated endovascular aneurysm repair for complex abdominal aortic aneurysms

  Cost OSR QALY OSR Cost fEVAR QALY fEVAR Difference in cost 95% CI   Difference in QALY 95% CI   ICER p (20 k) p (30 k)
Base-case 16,067 4.333 31,673 4.542 15,606 8391 22,512 0.209 − 0.124 1.311 74,580 0.090 0.158
Model2 16,246 4.626 31,604 4.544 15,358 8126 22,902 − 0.082 − 0.167 0.090 Dominated 0.001 0.003
Model3 15,860 4.017 31,694 4.554 15,834 8383 23,611 0.537 − 0.072 1.944 29,498 0.269 0.401
Model4 15,801 3.923 31,648 4.295 15,848 8467 23,859 0.372 − 0.318 1.707 42,584 0.224 0.318
Model5 16,194 4.525 31,762 4.615 15,567 8126 23,379 0.090 − 0.083 0.612 173,452 0.019 0.046
Model6 16,032 4.303 31,876 4.547 15,843 8438 23,193 0.243 − 0.071 1.136 65,154 0.077 0.165
Model7 18,292 4.353 31,665 4.548 13,373 6089 20,803 0.196 − 0.118 1.101 68,348 0.100 0.169
Model8 16,047 4.344 22,948 4.545 6901 − 804 14,238 0.201 − 0.123 1.308 34,373 0.249 0.330
  1. OSR open surgical repair, fEVAR fenestrated endovascular aneurysm repair, ICER incremental cost effectiveness ratio, QALY quality-adjusted life years, Pr(X) probability that fEVAR is cost-effective at threshold of X(£), Dominated fEVAR had greater cost and lower health benefit
  2. Scenario 2: Odds ratio (OR) of operative mortality favours OSR
  3. Scenario 3: OR of operative mortality is more favourable to fEVAR than the base-case
  4. Scenario 4: Greater base-line risk of operative mortality
  5. Scenario 5: Lower base-line risk of operative mortality
  6. Scenario 6: No difference in late-aneurysm related deaths between groups
  7. Scenario 7: No difference in late re-interventions between groups
  8. Scenario 8: Lower price of endovascular device