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Table 3 Direct health care costs

From: Cost-effectiveness of human papillomavirus vaccination in Germany

Parameter Direct costs (€, 2010 price level)
Vaccination costs
 Vaccine (initial series of 3 doses) 451.23
 Administration (initial series of 3 doses) 22.50
 Booster shot (per dose) 150.41
 Administration of booster shot (per dose) 7.50
Costs of screening, management of abnormal cytological screening results, and observational follow-up of CIN 1 and CIN 2
 Cytological screening (Pap smear) 25.23
 Follow-up smear (including quarterly Gynaecologist’s fee and optional colposcopy) ≤59 years 20.15
60+ years 20.33
 HPV test (including quarterly Gynaecologist’s fee) ≤59 years 44.77
60+ years 44.94
 HPV test and follow-up smear (including quarterly Gynaecologist’s fee) ≤59 years 50.55
60+ years 50.73
 Colposcopy (including quarterly Gynaecologist’s fee) ≤59 years 14.37
60+ years 14.54
 Biopsy and histology 129.47
Costs of CIN/CIS treatment and post-treatment follow-up
 Conisation of the cervix (CIN 1 and CIN 2) ≤39 years 525.05
40–59 years 531.22
60+ years 534.17
 Treatment of CIN 3 and CIS 1621.53
 Post-treatment follow-up of CIN/CIS (year 1 and 2 after treatment) ≤59 years 70.71
60+ years 71.06
Costs of cervical cancer treatment and post-treatment follow-up
 Diagnostics of symptom-detected cervical cancer ≤59 years 323.03
60+ years 324.08
 Diagnostics of screen-detected cervical cancer ≤59 years 179.18
60+ years 180.06
 Treatment of cervical cancer (FIGO I) ≤59 years 7586.98
60+ years 7591.22
 Treatment of cervical cancer (FIGO II) ≤59 years 11,455.22
60+ years 11,456.94
 Treatment of cervical cancer (FIGO III) ≤59 years 12,380.21
60+ years 12,380.70
 Treatment of cervical cancer (FIGO IV) ≤59 years 10,615.72
60+ years 10,616.21
 Post-treatment follow-up of cervical cancer (year 1 after treatment) ≤49 years 841.53
50–59 years 835.65
60+ years 836.35
 Post-treatment follow-up of cervical cancer (year 2 after treatment) ≤49 years 428.13
50–59 years 422.25
60+ years 422.95
 Post-treatment follow-up of cervical cancer (year 3 after treatment) ≤49 years 352.42
50–59 years 346.54
60+ years 347.24
 Post-treatment follow-up of cervical cancer (year 4 and 5 after treatment) ≤49 years 282.50
50–59 years 276.62
60+ years 276.97
 Post-treatment follow-up of cervical cancer (from year 6 after treatment onwards) ≤49 years 262.35
50–59 years 256.47
60+ years 256.65
 Inpatient palliative care and treatment 7518.09
Costs of genital warts treatment
 Treatment of genital warts in females 572.14
 Treatment of genital warts in males 396.69
  1. CIN cervical intraepithelial neoplasia, CIS carcinoma in situ, FIGO International Federation of Gynecology and Obstetrics