The value of using a brain laser interstitial thermal therapy (LITT) system in patients presenting with high grade gliomas where maximal safe resection may not be feasible

Table 2 Studies examining the use of craniotomy with high grade gliomas in areas of eloquence

Study	Number patients identified with tumors in areas of eloquence	Tumor type	Length of stay	Extent resection	KPS (presurgery/postsurgery)	Major complications^a
Sawaya [14]	154	Metastatic disease 48 %; GBM 27 %	Median 5 days	37 % had <95 % EOR	Post 32 % improved; 58 % no change; 9 % deterioration	13 %
Lacroix [13]	79	rGBM 17 % GBM 83 %	N/A	78 %	N/A	9 %
Jackson [16]	78	GBM	N/A	Median 96 %	N/A	12.8 %
Kim [17]	200	Primarily GBM	N/A	125/200 patients had a GTR (63 %) [defined as ≥95 %]; 20/200 (14 %) STR, 46/200 (23 %) partial resection	N/A	11 %
Sanai [9]	40	Insular gliomas WHO Type III & IV	N/A	87.5 % had <90 % EOR	N/A	4.8 %
Kuhnt [12]	79	GBM rGBM	N/A	78.2 %	N/A	9 %
Kreig [11]	47	GBM; anaplastic astrocytoma, diffuse astrocytoma	N/A		90 % going to 80 %	8.5 %
Chaichana [10]	146	GBM	Median 4 days	81 ± 1.6 %	N/A	7.3 % overall. However this was not broken out by complications in areas of eloquence
Schucht [8]	67	GBM	N/A	73 % GTR 27 % STR	N/A	4.5 % with persistent motor deficit

KPS Karnofsky performance scale, GTR gross total resection, STR subtotal resection
^aMajor complications = neurocognitive complications extending >3 months post surgery

ISSN: 1478-7547