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Table 2 Studies examining the use of craniotomy with high grade gliomas in areas of eloquence

From: The value of using a brain laser interstitial thermal therapy (LITT) system in patients presenting with high grade gliomas where maximal safe resection may not be feasible

Study Number patients identified with tumors in areas of eloquence Tumor type Length of stay Extent resection KPS (presurgery/postsurgery) Major complicationsa
Sawaya [14] 154 Metastatic disease 48 %; GBM 27 % Median 5 days 37 % had <95 % EOR Post 32 % improved; 58 % no change; 9 % deterioration 13 %
Lacroix [13] 79 rGBM 17 %
GBM 83 %
N/A 78 % N/A 9 %
Jackson [16] 78 GBM N/A Median 96 % N/A 12.8 %
Kim [17] 200 Primarily GBM N/A 125/200 patients had a GTR (63 %) [defined as ≥95 %]; 20/200 (14 %) STR, 46/200 (23 %) partial resection N/A 11 %
Sanai [9] 40 Insular gliomas WHO Type III & IV N/A 87.5 % had <90 % EOR N/A 4.8 %
Kuhnt [12] 79 GBM
rGBM
N/A 78.2 % N/A 9 %
Kreig [11] 47 GBM; anaplastic astrocytoma, diffuse astrocytoma N/A   90 % going to 80 % 8.5 %
Chaichana [10] 146 GBM Median 4 days 81 ± 1.6 % N/A 7.3 % overall. However this was not broken out by complications in areas of eloquence
Schucht [8] 67 GBM N/A 73 % GTR 27 % STR N/A 4.5 % with persistent motor deficit
  1. KPS Karnofsky performance scale, GTR gross total resection, STR subtotal resection
  2. aMajor complications = neurocognitive complications extending >3 months post surgery