Table 4 Univariate sensitivity analysis of ICER results of PCV13 vs PCV10 vs no vaccination in Colombian children younger than 5 years, 2014
Base case | Lowest value | Highest value | |||||||
|---|---|---|---|---|---|---|---|---|---|
Base case value | ICER | Value to prove | ICER | Value to prove | ICER | ||||
NV vs PCV10 | PCV10 vs PCV13 | NV vs PCV10 | PCV10 vs PCV13 | NV vs PCV10 | PCV 10 vs PCV13 | ||||
Discount rate | 3% | 813,41 | - 417,53 | 2% | 612,22 | - 338,43 | 5% | 1.288,37 | - 572,40 |
Vaccine costs (US$) | |||||||||
PCV10 | 45,36 | 813,41 | -417,53 | 41,12 | 669,04 | - 13,68 | 49,60 | 957,77 | - 821,39 |
PCV13 | 50,04 | 813,41 | - 417,53 | 45,34 | 813,41 | - 866,01 | 54,74 | 813,41 | - 30,94 |
Medical costs (US$) | |||||||||
Avoided cases | Mean values | 813,41 | - 417,53 | Mean values | 1.401,61 | - 185,47 | Mean values | 11.082,66 | - 12.268,58 |
PCV10 effectiveness | |||||||||
Sepsis | 0,6500 | 813,41 | -417,53 | 0,1110 | 5.804,26 | - 609,93 | 0,8620 | 288,94 | - 1.223,03* |
Meningitis | 0,6500 | 0,1110 | 0,8620 | ||||||
Pneumonia | 0,2240 | 0,0570 | 0,3610 | ||||||
OMA | 0,3240 | 0,2160 | 0,4040 | ||||||
PCV 13 effectiveness | |||||||||
Sepsis | 0,8910 | 813,41 | - 417,53 | 0,7370 | 813,41 | - 923,48* | 0,9630 | 813,41 | - 568,52 |
Meningitis | 0,8910 | 0,7370 | 0,9630 | ||||||
Pneumonia | 0,3030 | 0,1070 | 0,4468 | ||||||
OMA | 0,6810 | 0,6150 | 0,7944 | ||||||