Cost-effectiveness model comparing olanzapine and other oral atypical antipsychotics in the treatment of schizophrenia in the United States

Table 5 Treatment Switch Patterns by Reason for Switching and by Antipsychotic:

Medication Switch To →	Olanzapine	Risperidone	Quetiapine	Ziprasidone	Aripiprazole	Clozapine
Medication Switched From ↓ by Reason
Lack of Efficacy
Olanzapine	0%	20%	10%	20%	20%	30%
Risperidone	30%	0%	20%	20%	20%	10%
Quetiapine	20%	20%	0%	20%	20%	20%
Ziprasidone	30%	20%	20%	0%	30%	0%
Aripiprazole	20%	20%	20%	30%	0%	0%
Clozapine	0%	0%	0%	0%	0%	0%
Weight Gain
Olanzapine	0%	10%	10%	35%	45%	0%
Risperidone	0%	0%	10%	45%	45%	0%
Quetiapine	0%	30%	0%	35%	35%	0%
Ziprasidone	0%	0%	100%	0%	0%	0%
Aripiprazole	0%	0%	0%	5%	95%	0%
Clozapine	0%	20%	0%	40%	40%	0%
Diabetes
Olanzapine	0%	10%	10%	35%	45%	0%
Risperidone	0%	0%	10%	45%	45%	0%
Quetiapine	0%	30%	0%	35%	35%	0%
Ziprasidone	0%	0%	100%	0%	0%	0%
Aripiprazole	0%	0%	0%	5%	95%	0%
Clozapine	0%	20%	0%	40%	40%	0%
EPS
Olanzapine	0%	0%	30%	0%	30%	40%
Risperidone	40%	0%	30%	0%	30%	0%
Quetiapine	50%	0%	0%	0%	40%	10%
Ziprasidone	50%	0%	30%	0%	20%	0%
Aripiprazole	50%	0%	40%	0%	0%	10%
Clozapine	0%	0%	0%	0%	0%	100%
Hyperlipidemia
Olanzapine	0%	10%	10%	35%	45%	0%
Risperidone	0%	0%	10%	45%	45%	0%
Quetiapine	0%	30%	0%	35%	35%	0%
Ziprasidone	0%	0%	100%	0%	0%	0%
Aripiprazole	0%	0%	0%	5%	95%	0%
Clozapine	0%	20%	0%	40%	40%	0%
Patient Preference
Olanzapine	0%	50%	10%	20%	20%	0%
Risperidone	30%	0%	20%	20%	20%	0%
Quetiapine	20%	50%	0%	10%	10%	0%
Ziprasidone	20%	50%	10%	0%	10%	0%
Aripiprazole	20%	50%	10%	10%	0%	0%
Clozapine	0%	0%	0%	0%	0%	100%

ISSN: 1478-7547