Table 2 Relapse Input Values
Parameter | Value | Data Source | ||
|---|---|---|---|---|
Part A: | Â | Â | Â | Â |
Relapse Rates Requiring Hospitalization – For Initial Relapse | Full Adherence | Partial Adherence | Non-Adherence |  |
   Olanzapine | 2.0% | 3.6% | 5.2% |  |
   Risperidone | 3.2% | 5.8% | 8.8% | Lieberman et al, 2005 [23]; |
   Quetiapine | 4.9% | 8.8% | 14.0% | Gilmer et al, 2004 [16] |
   Ziprasidone | 4.2% | 7.4% | 11.6% |  |
   Aripiprazole | 4.2% | 7.4% | 11.6% | Assumed equal to ziprasidone |
Relapse Rates Not Requiring Hospitalization | Full Adherence | Partial Adherence | Non-Adherence | Â |
   Olanzapine | 2.0% | 3.2% | 4.8% | Lieberman et al, 2005 [23]; |
   Risperidone | 3.2% | 5.1% | 7.9% | Gilmer et al, 2004 [16]; |
   Quetiapine | 4.9% | 7.8% | 12.6% | Edwards et al, 2005 [18] |
   Ziprasidone | 4.2% | 6.6% | 10.5% |  |
   Aripiprazole | 4.2% | 6.6% | 10.5% | Assumed equal to ziprasidone |
Part B: | Â | Â | Â | Â |
Adjusted Relapse Rates Given a History of Relapse | Full Adherence | Partial Adherence | Non-Adherence | Â |
   Probability given history of 1 relapse | 19% | 40% | 58% |  |
   Probability given history of 2 relapses | 36% | 75% | 100% | Olfson et al., 2000 [65]; Tiihonen et al., 2006 [66] |
   Probability given history of 3 relapses | 42% | 88% | 100% |  |
Part C: | Â | Â | Â | Â |
Probability of Suicide Event Given Adherence Level | Fully Adherent | Partially Adherent | Non-Adherent | Â |
   Probability of suicide attempt | 0.25% | 0.76% | 1.00% | Ahn et al., 2007 [62] |
   Probability suicide attempt is fatal | 10.00% | Siris 2001 [60] | ||
   Cost of non-fatal suicide attempt | $140 (in addition to relapse costs) | Assumption | ||
   Cost of fatal suicide attempt | $0 | Assumption | ||