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Table 2 Percentage of drug recommendations based on outcome

From: Surrogate outcomes: experiences at the Common Drug Review

Factor

Final outcome¥(n = 26)

Other outcome* (n = 62)

Surrogate outcome§(n = 68)

DNL recommendation

15/26 (58%)

32/62 (52%)

28/68 (41%)

Statement of clinical uncertainty

13/26 (50%)

36/62 (58%)

26/68 (38%)

Price only economic factor

12/26 (46%)

30/62 (48%)

34/68 (50%)

Economic considered

11/26 (42%)

29/62 (47%)

28/68 (41%)

Price greater than comparators

19/26 (73%)

30/62 (48%)

29/68 (43%)

  1. ¥Final outcome = end unit of health effect.
  2. *Other = clinical endpoints and clinical scales.
  3. §Surrogate outcome = biomarker intended to substitute for a clinical endpoint.