Table 2 Main characteristics of the included studies
Study | Country | Type of study | Study design | Perspective | Type of treatment | Strategies compared | Main results (costs adjusted to 2021 US dollars) | CHEERS properly reported items | Potential conflicts of interest |
|---|---|---|---|---|---|---|---|---|---|
Grutters et al., 2010 [37] | The Netherlands | CUA | Model-based | Health care payer | Radiotherapy | Inoperable stage I NSCLC: Carbon-ion Proton therapy CRT SABR Operable stage I NSCLC: Carbon-ion Proton therapy SABR | Inoperable stage I NSCLC: SABR dominated proton therapy and CRT Carbon-ion was not cost-effective compared to SABR: ICER $100,081/QALY Operable stage I NSCLC: SABR dominated other techniques | 63% | Yes |
Sher; Wee; Punglia, 2011 [32] | United States | CUA | Model-based | Health care payer | Radiotherapy | CRT SABR RFA | SABR was cost-effective compared to 3D-CRT: ICER $7,393/ QALY SABR was cost-effective compared to RFA: ICER $17,375/QALY | 50% | No |
Puri et al., 2012 [31] | United States | CEA | Model-based | Health care payer | Radiotherapy and surgery | Surgical intervention SABR | Surgical intervention was cost-effective compared to SABR: ICER $9,444/LYG | 29% | No |
Shah et al., 2013 [34] | United States | CUA | Model-based | Health care payer | Radiotherapy and surgery | MOP: SABR Wedge resection COP: SABR Lobectomy | MOP: SABR dominated wedge resection COP: lobectomy was cost-effective compared to SABR: ICER $15,472/QALY | 50% | No |
Louie et al., 2014 [35] | Canada | CUA | Model-based | Health care payer | Radiotherapy and surgery | CRT SABR Sublobar resection Lobectomy Pneumonectomy BSC | SABR dominated CRT, sublobar resection, and BSC Lobectomy was cost effective compared to SABR: ICER $52,149/ QALY | 33% | Yes |
Mitera et al., 2014 [35] | Canada | CEA | Single study-based | Health care payer / Hospital | Radiotherapy | CRT SABR | SABR was cost-effective compared to CFRT: ICER $1,110/LYG*. $934/LYG** | 42% | Yes |
Smith et al., 2015 [33] | United States | CEA | Single study-based | Health care payer | Radiotherapy and surgery | SABR Sublobar resection Lobectomy | Sublobar resection was not cost-effective compared to SABR: ICER $51,585/LYG Lobectomy was cost-effective compared to SABR: ICER $32,345/ LYG | 33% | Yes |
Paix et al., 2018 [39] | France | CUA | Model-based | Health care payer | Radiotherapy and surgery | SABR Lobectomy | SABR dominated lobectomy | 67% | No |
Wolff et al., 2020 [39] | The Netherlands | CUA | Model-based | Health care payer | Radiotherapy and surgery | VATS resection SABR | SABR dominated VATS resection | 54% | Yes |