Healthcare costs of congenital cytomegalovirus (cCMV) disease in infants during the first two years of life: a retrospective German claims database analysis

Table 2 All-cause healthcare costs^a during the first 1–365 days of life

Cost domain	cCMV₉₀ cohort	“Representative” controls	Mean difference (CI)	p-value^b	cCMV_21-S cohort	“Healthy” controls	Mean difference (CI)	p-value^b
N (infants)	54	3240			24	1440
Outpatient
Sum	52,563	2,065,429			25,007	749,019
Mean	973	637	336 (234–438)	< 0.01	1042	520	522 (348–696)	< 0.01
SD	382	281			435	122
Min	328	0			328	214
Q1	695	505			818	440
Median	947	604			1009	516
Q3	1171	721			1244	589
Max	2082	6262			2082	1369
Inpatient
Sum	1,071,210	6,927,803			737,247	153,331
Mean	19,837	2138	17,699 (8477–26,921)	< 0.01	30,719	106	30,612 (13,639–47,586)	< 0.01
SD	34,555	9217			42,425	694
Min	0	0			3238	0
Q1	3,683	0			10,531	0
Median	8,343	0			14,723	0
Q3	19,407	986			29,972	0
Max	194,846	202,112			194,846	14,618
Pharmaceuticals
Sum	58,093	487,828			30,013	58,617
Mean	1076	151	925 (456–1395)	< 0.01	1251	41	1210 (528–1892)	< 0.01
SD	1757	707			1705	57
Min	1	0			6	0
Q1	71	29			85	15
Median	154	54			503	29
Q3	1184	103			1434	49
Max	7272	22,369			5903	1584
Aids and remedies^c
Sum	45,924	534,654			35,681	18,142
Mean	850	165	685 (175–1195)	< 0.01	1487	13	1474 (384–2565)	< 0.01
SD	1910	655			2726	55
Min	0	0			0	0
Q1	0	0			0	0
Median	208	29			394	0
Q3	850	165			1487	13
Max	10,694	17,737			10,694	757
Total
Sum	1,227,790	10,015,714			827,948	979,109
Mean	22,737	3091	19,646 (9814–29,477)	< 0.01	34,498	680	33,818 (15,811–51,825)	< 0.01
SD	36,838	9935			45,008	735
Min	655	0			5015	214
Q1	4958	653			12,950	479
Median	9759	863			20,924	569
Q3	21,623	2106			31,201	667
Max	212,552	211,210			212,552	15,662

cCMV congenital cytomegalovirus, cCMV₉₀ infants with cCMV diagnosis during the first 90 days of life, “Representative” infants with no cCMV or CMV diagnosis in the observation period, cCMV_21-S infants with inpatient cCMV diagnosis and symptoms during the first 21 days of life, “Healthy” infants with no ICD-10-GM diagnosis (except Z-diagnoses) until 4th preventive health checkup and no cCMV or CMV diagnosis in the observation period, CI 95% confidence interval, SD standard deviation, Min minimum; Q1, 25th percentile; Q3, 75th percentile, Max maximum
^aCosts are displayed in Euros (€). Figures were commercially rounded, which may result in minor calculation differences
^bP-value < 0.05 was considered as statistically significant (Wilcoxon rank-sum test)
^cData for aids and remedies were not completely available for all individuals in the database (18.5% cCMV₉₀ cohort and 31.6% respective controls, 12.5% cCMV_21-S cohort and 25.9% respective controls), and single imputation was applied using the mean costs of infants with available data

ISSN: 1478-7547