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Table 1 Key intervention and clinical parameters

From: Universal testing for hepatitis B and hepatitis C in the emergency department: a cost-effectiveness and budget impact analysis of two urban hospitals in the United Kingdom

Base case probabilities

Mean value (LTHT, Leeds)

Distribution

Mean Value (GSTT, London)

Distribution

Source

HBV Parameters

 Age of HBV cases

41.1

N/A

48.6a

N/A

LTHT [13]/GSTT [14]

 Prevalence (HBsAg)

0.5%

Beta (α = 73, β = 15,980)

0.9%

Beta (α = 235, β = 27,411)

LTHT/GSTT

 Proportion of diagnoses requiring linkage to care

53.4%

Beta (α = 39, β = 34)

57.4%

Beta (α = 135, β = 100)

LTHT/GSTT

 Proportion attending referral

69.2%

Beta (α = 27, β = 12)

71.1%

Beta (α = 96, β = 39)

LTHT/GSTT

 Proportion accepting treatment, post-referral (if indicated)

86.6%

Beta (α = 13, β = 2)

86.6%

Beta (α = 13, β = 2)

Parry [9]

 Proportion HBeAg + 

8.3%

Beta (α = 5, β = 55)

8.3%

Beta (α = 5, β = 55)

LTHT [13]

 Proportion inactive disease (HBeAg + seroconverted or HBeAg- inactive disease)

80%

Beta (α = 80, β = 20)

80%

Beta (α = 80, β = 20)

PHE

 Proportion cirrhotic

12%

Beta (α = 3, β = 22)

12%

Beta (α = 3, β = 22)

Parry

HCV Parameters

 Age of HCV cases

42.3

N/A

47.1a

N/A

LTHT/GSTT

 Prevalence (HCV RNA + or Ag +)

1.0%

Beta (α = 156, β = 15,897)

0.9%

Beta (α = 261, β = 27,396)

LTHT/GSTT

 Proportion of Ab + testing RNA + /Ag + upon reflex test

45.6%

Beta (α = 156, β = 186)

49.9%

Beta (α = 261, β = 262)

LTHT/GSTT

 Proportion of diagnoses requiring linkage to care

94.9%

Beta (α = 148, β = 8)

86.5%b

Beta (α = 217, β = 34)b

LTHT/GSTT

 Proportion attending referral

51.4%

Beta (α = 76, β = 72)

23.5%

Beta (α = 51, β = 166)

LTHT/GSTT

 Proportion receiving treatment, post-referral

53.9%

Beta (α = 41, β = 35)

51.0%

Beta (α = 26, β = 25)

LTHT/GSTT

 Proportion F0

57.5%

Dirichlet (42, 12, 2, 5, 12)

22.7%

Dirichlet (10,10,10,7,7)c

LTHT/Parry

 Proportion F1

16.4%

Dirichlet (42, 12, 2, 5, 12)

22.7%

Dirichlet (10,10,10,7,7)c

LTHT/Parry

 Proportion F2

2.7%

Dirichlet (42, 12, 2, 5, 12)

22.7%

Dirichlet (10,10,10,7,7)c

LTHT/Parry

 Proportion F3

6.8%

Dirichlet (42, 12, 2, 5, 12)

15.9%

Dirichlet (10,10,10,7,7)c

LTHT/Parry

 Proportion cirrhotic (F4)

16.4%

Dirichlet (42, 12, 2, 5, 12)

15.9%

Dirichlet (10,10,10,7,7)c

LTHT/Parry

 Proportion current PWID

61.3%

Beta (α = 84, β = 53)

61.3%

Beta (α = 84, β = 53)

LTHT

  1. Bold values indicate the element of the Dirichlet distribution (i.e. first value represents F0, second value F1 etc.)
  2. aThe mean age for individuals diagnosed in GSTT was estimated from the proportion of patients in each age band, using a midpoint to calculate the mean age
  3. bPatients who were uncontacted were assumed to require linkage to care
  4. cSample size of 44, Dirichlet (10,10,10,7,7)
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Cost Effectiveness and Resource Allocation

ISSN: 1478-7547

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