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Table 1 Demographic and baseline clinical data

From: Pharmacoeconomic analysis of biologics and methotrexate for rheumatoid arthritis from the standpoint of the number needed to treat concept under the Japanese health insurance system

 

bDMARDS group (n = 55)

MTX group (n = 66)

Control group (n = 28)

p value

Age, years

53.5

57.0

64.4

n.s

Female sex (%)

70.1

75.8

75.0

n.s

Disease duration, years

5.8** ††

1.8

0.9

 < 0.01

DAS28-ESR at baseline

4.36

3.96

3.75

n.s

CDAI at baseline

17.4**

15.9**

11.6

 < 0.01

Steinbrocker stage

** ††

 

 < 0.01

 I

22

56

19

 

 II

17

5

9

 

 III

9

4

0

 

 IV

7

1

0

 

Steinbrocker class

** ††

 

 < 0.01

 1

17

44

19

 

 2

30

22

9

 

 3

7

0

0

 

 4

1

0

0

 

MTX (%)

76.3**

100**

0

 < 0.01

MTX dose (mg/week)

6.8

7.2

0

n.s

Glucocorticoid (%)

40.0

24.2

25.0

n.s

SASP (%)

41.8*

66.7

75.0

 < 0.01

BUC (%)

23.6*††

59.1

53.6

 < 0.01

IGU (%)

14.7

12.1

25.0

n.s

TAC (%)

5.4

0.0

3.6

n.s

bDMARDs group

55 cases

   

TCZ

20

   

GLM

16

   

ETN

13

   

CZP

3

   

ABT

2

   

IFX

1

   
  1. bDMARDS biologic disease-modifying anti-rheumatic drugs, ABT abatacept, BUC bucillamine, CDAI clinical disease activity index, CZP certolizumab pegol, DAS28-ESR disease activity score in 28 joints using erythrocyte sedimentation rate, ETN etanercept, GLM golimumab, IFX infliximab, IGU iguratimod, MTX methotrexate, SASP salazosulfapyridine, TAC tacrolimus, TCZ tocilizumab
  2. *p < 0.05 compared with control group; **p < 0.01 compared with control group
  3. p < 0.05 compared with MTX group; ††p < 0.01 compared with MTX group