Table 1 Model parameters
Input parameter | Deterministic value | Values in one-way sensitivity and threshold analyses | Values in probabilistic sensitivity analyses | Assumption on distribution in probabilistic sensitivity analysis | Source |
|---|---|---|---|---|---|
Costs | |||||
SilAtro-5-90 costs per month (C) | €6.73 | L: €3.37 | – | Fixed | Palm et al. |
U: €10.10 | |||||
SilAtro-5-90 costs per month (AA) | €13.45 | L: €6.73 | – | Fixed | Palm et al. |
U: €20.18 | |||||
Tonsillectomy surgery (C) | €3495 | L: €1748 | – | Fixed | German Diagnosis Related Groups (DRG) data 2019 |
U: €5243 | |||||
Tonsillectomy surgery Adolescents and Adults (AA) | €2538 | L: €1269 | – | Fixed | German Diagnosis Related Groups (DRG) data 2019 |
U: €3807 | |||||
Antibiotics (1-week course) (C) | €12.41 | L: €6.21 | – | Fixed | German pharmacy data 2019 |
U: €18.62 | |||||
Antibiotics (1-week course) (AA) | €13.09 | L: €6.55 | – | Fixed | German pharmacy data 2019 |
U: €19.64 | |||||
Pharmaceutical dispensing fee | €5 per item for adults | – | – | Fixed | German pharmacy data 2019 |
General practitioner (per consultation) | €28 | L: €14 | – | Fixed | Data from the Association of Statutory Health Insurance Physicians 2019 |
U: €42 | |||||
Daily productivity loss cost | €175.94 | L: €87.97 | α = 6.736 | Gamma | Federal Office of Statistics 2019 |
U: €263.91 | λ = 0.038 | ||||
Travel time to/from GP | 1.5 hours | L: 0.75 hours | – | Fixed | Assumption linked to mean travel distance |
U: 2.25 hours | |||||
Travel time to/from hospital | 3 hours | L: 1.5 hours | – | Fixed | Assumption linked to mean travel distance |
U: 4.5 hours | |||||
Time out of role due to ATI per treatment cycle in intervention group | 0.05 daysa | L: 0.025 | α = 1.082 | Gamma | Palm et al. |
U: 0.075 | λ = 20.945 | ||||
Time out of role due to ATI per treatment cycle in control group | 0.16 daysa | L: 0.08 days | α = 2.217 | Gamma | Palm et al. |
U: 0.24 days | λ = 13.917 | ||||
Discount rate costs | 3.0% | L: 0% | – | Fixed | Eunethta |
U: 6% | |||||
Discount rate outcomes | 3.0% | L: 0% | – | Fixed | Eunethta |
U: 6% | |||||
Effectiveness and other parameters | |||||
Number of ATIs in 12 months prior to baseline | 2.5 | L:2 | Min.: 2 | Pert | Palm et al. |
U:3.75 | Max.: 3.75 | ||||
Probability of having an ATI in cycle with intervention | 0.11 | L: 0.055 | α = 0.323 | Beta | Palm et al. |
U: 0.165 | β = 2.629 | ||||
Probability of having an ATI in cycle with usual care only | 0.21 | L: 0.105 | α = 1.113 | Beta | Palm et al. |
U: 0.315 | β = 4.185 | ||||
Number of expected ATIs in cycle with intervention if patient has an ATI | 0.54 | L:0.27 | α = 1.736 | Gamma | Palm et al. |
U: 0.81 | λ = 3.217 | ||||
Number of expected ATIs in cycle with usual care only if patient has an ATI | 0.66 | L: 0.33 | α = 2.089 | Gamma | Palm et al. |
U: 0.99 | λ = 3.176 | ||||
Probability of ATI being treated with antibiotics in intervention group | 0.37 | L:0.185 | α = 3.407 | Beta | Palm et al. |
U: 0.555 | β = 5.811 | ||||
Probability of ATI being treated with antibiotics for ATI in usual care only group | 0.58 | L: 0.29 | α = 1.939 | Beta | Palm et al. |
U:0.87 | β = 1.392 | ||||
Probability of surgery if 4 or more ATIs per year (%) | 0.25 | L:0.125 | – | Fixed | Authors’ assumption |
U:0.375 | |||||
Probability of all-cause mortality per cycle (%) (C) | 0.000128452 | L: 0.000064226 | – | Fixed | WHO Global Health Observatory 2021 |
U: 0.000192678 | |||||
Probability of all-cause mortality (%) per cycle (AA) | 0.0007043578 | L: 0.0003521789 | α = 5.299 | Beta | WHO Global Health Observatory 2021 |
U: 0.0010565367 | β = 7518.025 | ||||
Probability of mortality following tonsillectomy (%) | 0.00242348 | L: 0.001938784 | α = 37.407 | Beta | Østvoll et al. 2015 |
U: 0.002908176 | β = 15397.71 | ||||