Improving the monitoring of chronic heart failure in Argentina: is the implantable pulmonary artery pressure with CardioMEMS Heart Failure System cost-effective?

Alcaraz, Andrea; Rojas-Roque, Carlos; Prina, Daniela; González, Juan Martín; Pichon-Riviere, Andrés; Augustovski, Federico; Palacios, Alfredo

doi:10.1186/s12962-021-00295-3

Cost Effectiveness and Resource Allocation

Table 1 Summary of input parameters

From: Improving the monitoring of chronic heart failure in Argentina: is the implantable pulmonary artery pressure with CardioMEMS Heart Failure System cost-effective?

Parameter	Base case	Variability range^a	Probability distribution	Source
Clinical, efficacy and epidemiological parameters
Baseline mean age of HF patients entering model	66	61 to 69	Normal	Weighted mean based on heart failure registries in Argentina
Baseline risk of HF hospital admission	1.13	0.68 to 1.55	Beta	Author estimations based on 21, 35, 36
HR of HF hospital admission, CardioMEMS cohort	0.48	0.38 to 0.67	Log normal	Meta-analysis based on 21, 35, 36
Baseline risk of mortality at 12 month of follow-up	0.16	0.14 to 0.18	Beta	35
HR of risk of mortality due to HF hospital admission	3.32	1.00 to 5.00	Log normal	51
Complications, treatment cohort (1–7 month)	0.03	0.02 to 0.04	Beta	49
Mortality due to device implantation procedure (1–7 month)	0.004	0.003 to 0.005	Beta	49
Utility parameters
Baseline utility	0.711	0.027	Beta	21
Monthly change of utility for month 1 to 6, treatment cohort	0.001	0.001	Beta	21
Monthly change of utility for month 7 to 60, treatment cohort	0.003	0.003	Beta	21
Monthly change of utility for month 1 to 6, control cohort	−0.005	0.004	Beta	21
Monthly change of utility for month 7 to 60, control cohort	−0.003	0.003	Beta	21
Disutility of HF hospital admission	0.045	0.012	Beta	28
Costs parameters, in ARS
Cost of CardioMEMS device	1,392,182	1,044,137 to 1,740,228	Normal	Abbott
Implant procedure	SS: 100,878 PS: 137,090	SS: 75,659 to 126,098 PS: 102,818 to 171,363	Normal	56
Weighted average cost of device complications^b	SS: 144,482 PS: 193,445	SS: 108,362 to 180,603 PS: 145,084 to 227,954	Normal	56
Monthly device monitoring cost	SS: 973 PS: 1,502	SS: 730 to 1,217 PS: 1,126 to 1,877	Normal	56
Standard HF care cost	SS: 4,512 PS: 5,440	SS: 3,384 to 5,641 PS: 4,080 to 6,800	Normal	56
Hospital admission for HF cost	SS: 362,788 PS: 534,983	SS: 272,091 to 453,485 PS: 401,237 to 655,753	Normal	56–58

PSA Probabilistic sensibility analysis, HF heart failure, HR hazard ratio, LMCCF last mothly change carried forward, SS Social Security, PS Private Sector
^aVaribility range for the clinical, efficacy and epidemiological parameters are reported as 95% confidence interval; variability range for the utility parameters are presented as standard deviation; variability range for the cost parameters are reported as minimum and maximum values
^bThe costs of the eight CardioMEMS complications were estimated as a weighted average according to its frequency
Exchange rate US $1 = ARS 76.95

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ISSN: 1478-7547

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