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Table 1 Summary of input parameters

From: Improving the monitoring of chronic heart failure in Argentina: is the implantable pulmonary artery pressure with CardioMEMS Heart Failure System cost-effective?

Parameter Base case Variability rangea Probability distribution Source
Clinical, efficacy and epidemiological parameters
 Baseline mean age of HF patients entering model 66 61 to 69 Normal Weighted mean based on heart failure registries in Argentina
 Baseline risk of HF hospital admission 1.13 0.68 to 1.55 Beta Author estimations based on 21, 35, 36
 HR of HF hospital admission, CardioMEMS cohort 0.48 0.38 to 0.67 Log normal Meta-analysis based on 21, 35, 36
 Baseline risk of mortality at 12 month of follow-up 0.16 0.14 to 0.18 Beta 35
 HR of risk of mortality due to HF hospital admission 3.32 1.00 to 5.00 Log normal 51
 Complications, treatment cohort (1–7 month) 0.03 0.02 to 0.04 Beta 49
 Mortality due to device implantation procedure (1–7 month) 0.004 0.003 to 0.005 Beta 49
Utility parameters
 Baseline utility 0.711 0.027 Beta 21
 Monthly change of utility for month 1 to 6, treatment cohort 0.001 0.001 Beta 21
 Monthly change of utility for month 7 to 60, treatment cohort 0.003 0.003 Beta 21
 Monthly change of utility for month 1 to 6, control cohort −0.005 0.004 Beta 21
 Monthly change of utility for month 7 to 60, control cohort −0.003 0.003 Beta 21
 Disutility of HF hospital admission 0.045 0.012 Beta 28
Costs parameters, in ARS
 Cost of CardioMEMS device 1,392,182 1,044,137 to 1,740,228 Normal Abbott
 Implant procedure SS: 100,878
PS: 137,090 		SS: 75,659 to 126,098
PS: 102,818 to 171,363 		Normal 56
 Weighted average cost of device complicationsb SS: 144,482
PS: 193,445 		SS: 108,362 to 180,603
PS: 145,084 to 227,954 		Normal 56
 Monthly device monitoring cost SS: 973
PS: 1,502 		SS: 730 to 1,217
PS: 1,126 to 1,877 		Normal 56
 Standard HF care cost SS: 4,512
PS: 5,440 		SS: 3,384 to 5,641
PS: 4,080 to 6,800 		Normal 56
 Hospital admission for HF cost SS: 362,788
PS: 534,983 		SS: 272,091 to 453,485
PS: 401,237 to 655,753 		Normal 56–58
  1. PSA Probabilistic sensibility analysis, HF heart failure, HR hazard ratio, LMCCF last mothly change carried forward, SS Social Security, PS Private Sector
  2. aVaribility range for the clinical, efficacy and epidemiological parameters are reported as 95% confidence interval; variability range for the utility parameters are presented as standard deviation; variability range for the cost parameters are reported as minimum and maximum values
  3. bThe costs of the eight CardioMEMS complications were estimated as a weighted average according to its frequency
  4. Exchange rate US $1 = ARS 76.95
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Cost Effectiveness and Resource Allocation

ISSN: 1478-7547

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