From: Cost-utility analysis of imrecoxib compared with diclofenac for patients with osteoarthritis
Adverse events | Source | ||||||
---|---|---|---|---|---|---|---|
 | GI discomforts | Symptomatic ulcer | Complicated GI | Stroke | MI | HF | |
Cost ($)a | Â | Â | Â | ||||
Initial states | 10.52 + cost of medication of OA | 34.57 | 1354.15 | 1289.92 | 5190.93 | 1182.33 | SuValue Database (Additional fie 1: Table S4-5) |
Post states | – | 0.81b | 21.54b | 619.59 | 948.47 | 451.29 | [13] |
Utility weights for AEs (1 = OA patients without any AEs) |  | ||||||
Initial states | 0.73 | 0.55 | 0.46 | 0.35 | 0.37 | 0.71 | [7] |
Post states | 1.00 | 0.98 | 0.98 | 0.71 | 0.88 | 1.00 | [7] |
Absolute AEs rates (%) | Â | ||||||
Diclofenac | 21.30 | 0.14 | 0.07 | 0.06 | 0.09 | 0.02 | [11] |
Relative risk of AEs rate of different treatment strategies | |||||||
Celecoxib vs. diclofenac | 0.66 | 0.43 | 0.68 | 0.51 | 1.40 | 1.42 | [9] |
Imrecoxib vs. celecoxib | 0.50 | 1.36 | 0.50 | 1.00 | 1.00 | 1.00 | |
Imrecoxib vs. diclofenac | 0.33 | 0.58 | 0.34 | 0.51 | 1.40 | 1.42 | – |
Relative risk of AEs rate with the addition of a PPI | |||||||
Diclofenac | 0.43 | 0.37 | 0.46 | 1.00 | 1.00 | 1.00 | [5] |
imrecoxib | 0.25 | 0.25 | 0.25 | 1.00 | 1.00 | 1.00 | [5] |