Table 1 AM results in patients with moderate to severe DED:

Cheng AMS, et al. Ocul. Surg. 2016

[10]

Retrospective review of 15 eyes in patients with moderate to severe dry eye disease and refractory to maximal medical treatment. Demographics: 2 males/8 females; age: 68.7 ± 16.2 years

10

Patients symptom free at 4 months. However after 4 months, symptoms recurred including itchy eye, blurred vision, burning sensation, dryness

John T, et al. Jr. Ophthal. 2017

[11]

Randomized controlled trial 17 patients—CAM (9) or conventional maximal treatment (8)—with moderate to severe dry eye disease. Demographics: 4 males/13 females; age: 67.8 ± 8.9 years; all presenting with moderate to severe DED grades 2–4

17

Patients in CAM group—symptoms improved dramatically after 3 months with adjunctive topical meds as needed. Control group symptoms remained the same with maximal medical treatment

McDonald MB, et al. Clin. Ophthal. 2018

[12]

Retrospective review of 97 eyes in patients with severe dry eye disease refractory to maximal medical treatment. Demographics: 12 male/69 female; all with severe DED; 86% manifested with superficial punctate keratitis

84

Patients ocular surface stable after 3 months with continued use of conventional treatments including artificial tears (96%); Restasis (57%) and steroids (32%)

Morkin MI, et al. Ocul. Surf. 2018

[13]

Retrospective cases series of 9 patients with DED and acute neuropathic corneal pain. Demographics: 1 male/8 females; age: 58.8 ± 4.3 years

9

During follow up of 9.3 ± 0.8 months, pain severity improved significantly. As well, only 2 out of the 9 patients required re-implantation due to pain recurrence