Skip to main content

Table 1 Summary of model inputs

From: Cost-effectiveness analysis of ceritinib vs. crizotinib in previously untreated anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) in Hong Kong

Model input Value Notes/sources
Utility inputs for disease states
 Stable disease: ceritinib 0.81 ASCEND-4 (Soria et al. [5])
 Treatment response: Ceritinib 0.81
 Stable disease: crizotinib 0.81 Felip et al. [22, 26]
 Treatment response: Crizotinib 0.81
 Disease progression: all treatments 0.64 Chouaid et al. [27]
Hazard ratios
 PFS: Ceritinib vs. Crizotinib 0.64 (0.47, 0.87) Li et al. [17]
 OS: Ceritinib vs. Crizotinib 0.82 (0.54, 1.27)
Unit cost
 Ceritinib (450 mg) $52.77 per pill Hong Kong Hospital Authority [1]
 Crizotinib (250 mg) $113.21 per pill
Relative dose intensity
 Ceritinib 92.2% ASCEND-8 [6]
 Crizotinib 92.0% PROFILE 1014 (Australian Department of Health) [15]
Monthly medical costs/ pre-progression frequency/post-progression frequency
 Cancer nurse $12.82/ 0.1 time per month/0.1 time per month Hong Kong Hospital Authoritya
 Outpatient visit $142.31/ 1 time per month / 1.08 times per month
 Pharmacist $49.36/ 1 time per month /0.1 time per month
 Complete blood count $17.31 / 1 time per month / 1.08 times per month
 CT scan $1,730.77/ 0.25 time per month / 0.18 time per month
 MRI $602.56/ 0.17 time per month /0.12 time per month
 X-Ray $24.36/ 1 time per month / 1.08 times per month
 Serum chemistry $116.03/ 1 time per month / 1.08 times per month
Total post-progression treatment costs
 Ceritinib $11,142.92 ASCEND-4; PROFILE 1014 [15]; Hong Kong Hospital Authority [1] and literature
 Crizotinib $10,385.68
 Terminal care cost $24,089.00 Wong et al. [25]
Costs associated with AEs
 Ceritinib $2,024.93 ASCEND-8 (Cho et al. [6] PROFILE 1014 (Solomon et al. [15]) Hong Kong Hospital Authority [1]
 Crizotinib $1,236.39
  1. AE, adverse event; CT, computed tomography; MRI, magnetic resonance imaging; OS, overall survival; PFS, progression-free survival
  2. All costs were converted to 2018 US Dollars (USD) from Hong Kong Dollars (HKD) using a prevailing exchange rate obtained from the Linked Exchange Rate System in Hong Kong (1 USD = 7.8 HKD)
  3. aHong Kong Monetary Authority. Fees and Charges. https://www.ha.org.hk/visitor/ha_visitor_index.asp?Content_ID=10045&Lang=ENG Accessed January 10, 2020