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Table 3 Vaccination cost estimates and intervention costs in 2018 US$

From: Introduction of birth dose of hepatitis B virus vaccine to the immunization program in Ethiopia: an economic evaluation

Parameter Base assumptions Range for sensitivity analysis Source
Vaccination cost
Recurrent costs
   Vaccinea 0.25200 [23, 29]
   Syringes and safety boxb 0.04824 [23, 30]
   Transport and maintenance 0.02206 [12, 31]
   Cold chain storage 0.02213 [12, 31]
  Capital costs
   Social mobilization 0.05276 [12, 31]
   Training 0.34532 [12, 31]
  Total average costs per vaccinated child 0.74251 0.50–1.00  
Medical care costs (US$)
  Initial assessment and diagnosis cost 113.16 56.58–226.32 Local data
  Drug treatment 60.35 30.17–120.70 [32, 33]
  Monitoring on treatment 37.00 18.50–74.00 Local data
  Monitoring without treatment 18.50 9.25–37.00 Local data
  Average annual cost of hospital admission for decompensated cirrhosis 153.88 76.94–307.76 [34]
  Average annual cost of hospital admission for hepatocellular carcinoma 153.88 76.94–307.76 [34]
  Treatment cost of symptomatic acute infection 40.00 20.00–80.00 Assumptions
  Treatment cost of fulminant hepatitis 200.00 100.00–400.00 Assumptions
  1. aVaccine wastage rate was assumed to be 20% and a freight rate of 6%
  2. bWastage and freight rates were 10% and 15%, respectively