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Table 2 Design of the SBRT treatment of HCC models in studies

From: Health economic evaluation of stereotactic body radiotherapy (SBRT) for hepatocellular carcinoma: a systematic review

VariableHayeon Kim [17]Leung [18]Pollom [19]Leung [20]
Cycle periodEvery monthEvery monthEvery month 
Time horizonLifetime5 yearsLifetime5 years
Natural history state setting
 Stable diseaseNo disease progression, stable after treatmentStable diseaseStable disease after treatment, stable disease after local progressionStable disease
 Progression of diseaseLocal recurrence, local or distant metastasisDisease progressionLocal metastasis, distant metastasisDisease progression
 DeathDeathDeathDeathDeath
Parameter setting and source
 Transition probabilitySystemic literature reviewSource was one RCT and one sorafenib and SBRT in clinical trial of advanced HCC; the transition probability of the health state was calculated using a formulaSystemic literature reviewSource was one stage I/II RCT of SBRT and one stage II RCT
 Life qualitySystemic literature reviewSource was one RCT and one sorafenib and SBRT in clinical trial of advanced HCCSystemic literature reviewSource was one stage I/II RCT of SBRT and one stage II RCT
 CostSource was one 2014 Medicare payment dataset of the total treatment cost including the potential complication costs, hospitalization, retreatment, and palliative chemotherapySource was from 2015 National Health Insurance Research Database of Taiwan, which was mainly the direct medical cost including drug costs, laboratory tests, physician visits, pharmacy dispensing fees, administration and nursing care feesSource was 2015 Medicare Services physician fee scheduleSource was from 2016 National Health Insurance Research Database of Taiwan, which was mainly the direct medical cost, including drug costs, laboratory tests, physician visits, pharmacy dispensing fees, and treatment costs for grade 3/4 adverse events
 Discount rate3%3%3%3%
Sensitivity analysis
 MethodOne-way and probabilistic sensitivity analysesOne-way and probabilistic sensitivity analysesOne-way and probabilistic sensitivity analysesOne-way and probabilistic sensitivity analyses
 Choice of variableAll parametersAll parametersAll parametersAll parameters
 Threshold value (each QALY)$100,000NT $2213,145$100,000NT $2157,024