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Table 3 Main findings of Cost-effectiveness studies comparing IMRT and 3D-CRT for localized prostate cancer

From: Model-based cost-effectiveness analysis of external beam radiation therapy for the treatment of localized prostate cancer: a systematic review

Study (authors, year) Results Conclusions
Mean cost QALYs ICER
Carter et al. (2014) [11] After 5 years
IMRT: $9932
3D-CRT: $9706
After 20 years
IMRT: $32,816
3D-CRT: $ 33,917
After 5 years
IMRT: 4.244
3D-CRT: 4.239
After 20 years
IMRT: 10.079
3D-CRT: 10.060
$41,572/QALY
IMRT is dominant
IMRT was estimated to have a modest long-term advantage over 3D-CRT in terms of both improved effectiveness and reduced cost
Hummel et al. (2012) [12] Scenario 1
IMRT: £6173
3D-CRT: £5184
Scenario 2
IMRT: £4946
3D-CRT: £4214
Scenario 3
IMRT: £4946
3D-CRT: £4486
Scenario 4
IMRT: £5687
3D-CRT: £7489
Scenario 1
IMRT: 6.802
3D-CRT: 6.792
Scenario 2
IMRT: 7.070
3D-CRT: 7.046
Scenario 3
IMRT: 7.070
3D-CRT: 6.983
Scenario 4
IMRT: 7.015
3D-CRT: 6.402
Scenario 1: £104,066/QALY
Scenario 2: £31,162/QALY
Scenario 3: £5295/QALY
Scenario 4: dominant strategy
If IMRT can be used to prolong survival, it is very cost-effective. Otherwise, cost-effectiveness is uncertain
Konski et al. (2005) [13] 70 years old with intermediate risk
IMRT: $33,837
3D-CRT: $21,377
70 years old with good risk
IMRT: $31,950
3D-CRT: $19,213
  70 years old with intermediate risk
US$16,182/QALY
70 years old with good risk
US$17,448/QALY
Intensity-modulated radiation therapy was found to be cost effective in the treatment of 70 years old man with prostate cancer
Konski et al. (2006) [14] 3D-CRT: $21,865
IMRT: $47,931
3D-CRT: 6.27
IMRT: 5.62
$40,101/QALY IMRT therapy was found to be cost-effective at the upper limits of acceptability
Yong et al. (2012) [15] 3D-CRT
$13,501
IMRT
$14,520
3D-CRT: 6.062
IMRT: 6.085
$26,768/QALY For radical radiation treatment of prostate cancer, IMRT seems to be cost-effective when compared with an equivalent dose of 3D-CRT
Cooperberg (2013) [16] IMRT: $37,718
3D-CRT: $27,636
IMRT: 9.6
3D-CRT: 10.3
Not calculated IMRT was found to be cost effective with a 0.5 QALYs gained
Zemplenyi et al. (2016) [17] 3D-CRT: €7160
IMRT: €6831
HF-IMRT:
€ 6.019
3D-CRT: €5.753
IMRT: €5.956
HF-IMRT: €5.957
3D-CRT dominated IMRT Compared to 3D-CRT, both IMRT and HF-IMRT resulted in more health gains at a lower cost