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Table 3 Main findings of Cost-effectiveness studies comparing IMRT and 3D-CRT for localized prostate cancer

From: Model-based cost-effectiveness analysis of external beam radiation therapy for the treatment of localized prostate cancer: a systematic review

Study (authors, year) Results Conclusions
Mean cost QALYs ICER
Carter et al. (2014) [11] After 5 years IMRT: $9932 3D-CRT: $9706 After 20 years IMRT: $32,816 3D-CRT: $ 33,917 After 5 years IMRT: 4.244 3D-CRT: 4.239 After 20 years IMRT: 10.079 3D-CRT: 10.060 $41,572/QALY IMRT is dominant IMRT was estimated to have a modest long-term advantage over 3D-CRT in terms of both improved effectiveness and reduced cost
Hummel et al. (2012) [12] Scenario 1 IMRT: £6173 3D-CRT: £5184 Scenario 2 IMRT: £4946 3D-CRT: £4214 Scenario 3 IMRT: £4946 3D-CRT: £4486 Scenario 4 IMRT: £5687 3D-CRT: £7489 Scenario 1 IMRT: 6.802 3D-CRT: 6.792 Scenario 2 IMRT: 7.070 3D-CRT: 7.046 Scenario 3 IMRT: 7.070 3D-CRT: 6.983 Scenario 4 IMRT: 7.015 3D-CRT: 6.402 Scenario 1: £104,066/QALY Scenario 2: £31,162/QALY Scenario 3: £5295/QALY Scenario 4: dominant strategy If IMRT can be used to prolong survival, it is very cost-effective. Otherwise, cost-effectiveness is uncertain
Konski et al. (2005) [13] 70 years old with intermediate risk IMRT: $33,837 3D-CRT: $21,377 70 years old with good risk IMRT: $31,950 3D-CRT: $19,213   70 years old with intermediate risk US$16,182/QALY 70 years old with good risk US$17,448/QALY Intensity-modulated radiation therapy was found to be cost effective in the treatment of 70 years old man with prostate cancer
Konski et al. (2006) [14] 3D-CRT: $21,865 IMRT: $47,931 3D-CRT: 6.27 IMRT: 5.62 $40,101/QALY IMRT therapy was found to be cost-effective at the upper limits of acceptability
Yong et al. (2012) [15] 3D-CRT $13,501 IMRT $14,520 3D-CRT: 6.062 IMRT: 6.085 $26,768/QALY For radical radiation treatment of prostate cancer, IMRT seems to be cost-effective when compared with an equivalent dose of 3D-CRT
Cooperberg (2013) [16] IMRT: $37,718 3D-CRT: $27,636 IMRT: 9.6 3D-CRT: 10.3 Not calculated IMRT was found to be cost effective with a 0.5 QALYs gained
Zemplenyi et al. (2016) [17] 3D-CRT: €7160 IMRT: €6831 HF-IMRT: € 6.019 3D-CRT: €5.753 IMRT: €5.956 HF-IMRT: €5.957 3D-CRT dominated IMRT Compared to 3D-CRT, both IMRT and HF-IMRT resulted in more health gains at a lower cost