Skip to main content

Advertisement

Table 3 Follow-up events, procedural resource use, and cost

From: Comparative cost-effectiveness of surgery, angioplasty, or medical therapy in patients with multivessel coronary artery disease: MASS II trial

  Year 1 Year 2 Year 3
PCI (n = 195) MT (n = 201) CABG (n = 195) PCI (n = 191) MT (n = 197) CABG (n = 191) PCI (n = 189) MT (n = 189) CABG (n = 185)
Clinical outcomes, n (%)
 Death 4 (2.1) 4 (2.0) 4 (2.1) 2 (1.0) 8 (4.1) 6 (3.1) 0 (0) 11 (5.8) 1 (0.5)
 AMI 3 (1.5) 6 (3.0) 2 (1.0) 4 (2.1) 9 (4.6) 4 (2.1) 0 (0) 11 (5.8) 0 (0)
 Stroke 1 (0.5) 3 (1.5) 3 (1.5) 0 (0) 3 (1.5) 3 (1.0) 1 (0.5) 2 (1.1) 3 (1.6)
 Angina 5 (2.6) 1 (0.5) 0 (0) 3 (1.6) 0 (0) 0 (0) 1 (0.5) 1 (0.5) 3 (1.0)
Resource use, n events/100 patients
 Repeat revascularization (any) 12.3 5.0 4.6 5.8 7.1 3.7 1.6 5.3 1.1
 PCI procedure 12.3 2.5 0.5 5.2 3.6 0.5 1.1 1.6 0.5
 CABG procedure 0.0 2.5 4.1 0.5 3.6 3.1 0.5 3.7 0.5
 Bare metal stent 11.3 3.0 1.0 4.2 4.6 0.5 1.1 1.6 0.5
 Balloon angioplasty 21.5 3.0 1.5 9.9 5.6 0.5 1.1 1.6 0.5
 Diagnostic catheterization 15.4 5.5 15.9 11.0 6.1 4.2 3.7 10.1 1.1
Cost per patient, $
 Medication 47 ± 32 [39] 80 ± 104 [64] 39 ± 29 [30] 93 ± 63 [78] 162 ± 210 [127] 78 ± 58 [60] 93 ± 63 [78] 163 ± 212 [127] 72 ± 53 [56]
 Outpatient service 116 ± 82 [91] 111 ± 116 [85] 90 ± 82 [61] 160 ± 99 [124] 200 ± 229 [157] 115 ± 72 [98] 146 ± 81 [123] 209 ± 223 [166] 110 ± 71 [97]
 PCI procedure 150 ± 433 [0] 34 ± 221 [0] 10 ± 141 [0] 63 ± 360 [0] 48 ± 290 [0] 6 ± 90 [0] 13 ± 127 [0] 20 ± 155 [0] 7 ± 91 [0]
 CABG procedure 0 48 ± 304 [0] 80 ± 387 [0] 10 ± 141 [0] 69 ± 361 [0] 61 ± 340 [0] 10 ± 141 [0] 72 ± 369 [0] 10 ± 143 [0]
 Revascularization procedure (any) 150 ± 433 [0] 83 ± 371 [0] 90 ± 410 [0] 73 ± 385 [0] 118 ± 456 [0] 48 ± 294 [0] 23 ± 190 [0] 92 ± 397 [0] 17 ± 234 [0]
 Total 221 ± 474 [54] 120 ± 408 [18] 146 ± 417 [16] 233 ± 432 [124] 316 ± 576 [160] 183 ± 365 [100] 171 ± 222 [123] 306 ± 489 [170] 131 ± 281 [97]
  1. Values in brackets represent medians
  2. MT medical treatment, PCI percutaneous coronary intervention, CABG coronary artery bypass graft, AMI acute myocardial infarction, $ American dollar
  3. aChi square test of homogeneity
  4. bKruskal–Wallis
  5. cP value refers to 5-years cumulative
  Year 4 Year 5 5-years cumulative
PCI (n = 188) MT (n = 178) CABG (n = 183) PCI (n = 182) MT (n = 170) CABG (n = 178) PCI (n = 195) MT (n = 201) CABG (n = 195) P valuec
Clinical outcomes, n (%)
 Death 7 (3.7) 8 (4.5) 6 (3.3) 5 (2.7) 2 (1.2) 7 (3.9) 18 (9.2) 33 (16.4) 24 (12.3) 0.098a
 AMI 5 (2.6) 2 (1.1) 1 (0.5) 2 (1.1) 2 (1.2) 7 (3.9) 14 (7.2) 30 (14.9) 14 (7.2) 0.022a
 Stroke 0 (0) 3 (1.7) 2 (1.1) 2 (1.1) 2 (1.2) 0 (0) 4 (2.1) 13 (6.5) 11 (5.6) 0.178a
 Angina 2 (1.1) 1 (0.6) 1 (0.5) 4 (2.2) 4 (2.4) 6 (3.4) 15 (7.7) 7 (3.5) 10 (5.1) 0.395a
Resource use, n events/100 patients
 Repeat revascularization (any) 3.2 1.7 0.0 5.5 7.6 1.1 27.7 24.9 10.3 0.001a
 PCI procedure 2.1 1.1 0.0 4.4 2.9 1.1 24.6 10.9 2.6 < 0.001a
 CABG procedure 1.1 0.6 0.0 1.1 4.7 0.0 3.1 13.9 7.7 < 0.001a
 Bare metal stent 0.5 1.1 0.0 3.3 4.1 1.1 20.0 13.4 3.1 0.014a
 Balloon angioplasty 2.7 1.1 0.0 4.4 5.3 1.1 39.0 15.4 3.6 < 0.001a
 Diagnostic catheterization 4.8 3.4 0.5 12.6 14.7 7.3 46.2 36.3 28.2 0.042a
Cost per patient, $
 Medication 93 ± 63 [78] 165 ± 218 [127] 77 ± 57 [72] 92 ± 63 [78] 166 ± 222 [127] 77 ± 57 [60] 403 ± 284 [329] 680 ± 939 [558] 334 ± 255 [262] < 0.001b
 Outpatient service 148 ± 83 [123] 199 ± 228 [158] 108 ± 63 [96] 162 ± 97 [127] 220 ± 246 [168] 120 ± 76 [100] 707 ± 373 [635] 867 ± 995 [733] 523 ± 306 [470] < 0.001b
 PCI procedure 18 ± 126 [0] 14 ± 131 [0] 0 48 ± 297 [0] 42 ± 257 [0] 14 ± 131 [0] 287 ± 717 [0] 149 ± 473 [0] 36 ± 226 [0] < 0.001b
 CABG procedure 20 ± 200 [0] 11 ± 146 [0] 0 21 ± 203 [0] 91 ± 413 [0] 0 60 ± 337 [0] 271 ± 676 [0] 151 ± 522 [0] < 0.001b
 Revascularization procedure (any) 38 ± 234 [0] 25 ± 195 [0] 0 69 ± 357 [0] 134 ± 508 [0] 14 ± 131 [0] 347 ± 802 [0] 420 ± 849 [0] 167 ± 553 [0] 0.003b
 Total 189 ± 283 [123] 229 ± 32 [161] 111 ± 65 [97] 235 ± 413 [133] 359 ± 606 [176] 142 ± 171 [103] 1402 ± 1780 [673] 1707 ± 2090[0] 877 ± 1184 [501] < 0.001b
  1. Values in brackets represent medians
  2. MT medical treatment, PCI percutaneous coronary intervention, CABG coronary artery bypass graft, AMI acute myocardial infarction, $ American dollar
  3. aChi square test of homogeneity
  4. bKruskal–Wallis
  5. cP value refers to 5-years cumulative