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Table 2 Parameter inputs of the model

From: Using a dynamic adherence Markov model to assess the efficiency of Respiratory Medication Therapy Adherence Clinic (RMTAC) on asthma patients in Malaysia

Parameter Value Range Distribution
Low High
Monthly transition probabilities between states A–D under RMTAC + UC
 A → B 0.122 0.03365 0.35673 Dirichlet
 A → C 0.152 0.04763 0.39112 Dirichlet
 A → D 0.030 0.00304 0.23896 Dirichlet
 B → A 0.382 0.18072 0.63454 Dirichlet
 B → C 0.032 0.00306 0.26248 Dirichlet
 B → D 0.058 0.00895 0.29784 Dirichlet
 C → A 0.184 0.08224 0.36201 Dirichlet
 C → B 0.008 0.00042 0.13430 Dirichlet
 C → D 0.043 0.00867 0.18760 Dirichlet
 D → A 0.088 0.01812 0.33530 Dirichlet
 D → B 0.051 0.00708 0.28827 Dirichlet
 D → C 0.088 0.01812 0.33530 Dirichlet
Effectiveness factor
 Asthma control OR 3.059 1.632 5.733 Log normal
 Medication adherence OR 1.89 1.08 3.30 Log normal
Monthly probabilities of low adherence level patient to have an exacerbation
 B → E 0.09273 0.07489 0.11021 Beta
 B → F 0.00412 0.00330 0.00495 Beta
 D → E 0.23237 0.19068 0.27191 Beta
 D → F 0.05390 0.04335 0.06432 Beta
Risks of high adherence level patient to have an exacerbation
 A → E HR 0.72 0.34 1.51 Log normal
 A → F HR 0.72 0.34 1.51 Log normal
 C → E HR 0.59 0.37 0.95 Log normal
 C → F HR 0.59 0.37 0.95 Log normal
Monthly probabilities of having good/poor asthma control after an exacerbation
 E → A 0.02528 0.01962 0.03132 Beta
 E → C 0.10484 0.07127 0.16332 Beta
 F → A 0.02394 0.01862 0.02961 Beta
 F → C 0.10738 0.07261 0.16990 Beta
Monthly probabilities of having an exacerbation after a recent exacerbation
 E → F 0.047 0.0376 0.0564 Beta
 F → E 0.047 0.0376 0.0564 Beta
Monthly probability of mortality after an exacerbation that does not involve hospitalization
 E → G 0.000059 0.000048 0.000071 Beta
Utilities input for base case analysis
 A 0.5583 0.4435 0.6731 Beta
 B 0.5583 0.4435 0.6731 Beta
 C 0.5316 0.3788 0.6844 Beta
 D 0.5316 0.3788 0.6844 Beta
 E 0.5311 0.4254 0.6368 Beta
 F 0.3842 0.2882 0.4802 Beta
Utilities input for PSA
 A 0.5598 0.4588 0.6608 Beta
 B 0.5598 0.4588 0.6608 Beta
 C 0.5316 0.3788 0.6844 Beta
 D 0.5316 0.3788 0.6844 Beta
 E 0.4514 0.3589 0.5439 Beta
 F 0.2919 0.2091 0.3747 Beta
Monthly direct cost ($)*
 A (maintenance) 38.78 33.77 43.78 Gamma
 B (maintenance) 39.70 34.70 44.71 Gamma
 C (maintenance) 42.48 37.46 47.50 Gamma
 D (maintenance) 38.67 35.62 45.64 Gamma
 E (ED management) 13.50 12.53 14.46 Log normal
 F (hospitalization) 552.13 468.03 636.23 Gamma
 RMTAC recruitment (cycle 0) 12.38 9.30 15.48 Gamma
 RMTAC 3 monthly follow-up (cycle 1–15) 2.23 1.91 2.54 Gamma
 RMTAC biannual follow-up (cycle 16 and above) 1.11 0.96 1.27 Gamma
  1. A, good control–high adherence; B, good control–low adherence; C, poor control–high adherence; D, poor control–low adherence; E, exacerbation without hospitalization (Emergency Department visit); F, severe exacerbation with hospitalization; G, death due to asthma; PSA, probabilistic sensitivity analysis; RMTAC, Respiratory Medication Therapy Adherence Clinic; UC, usual care
  2. * Monthly direct cost is expressed in 2014 US dollars ($)