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Table 4 Adverse event cost and prevalence

From: Cost-effectiveness analysis for midostaurin versus standard of care in acute myeloid leukemia in the United Kingdom

Adverse event

Unit cost (£)

Induction

Consolidation

Monotherapy

MIDO (%)

SOC (%)

MIDO (%)

SOC (%)

MIDO (%)

SOC (%)

Platelet count decreased

£2469.87

50.15

49.99

33.07

34.16

0.18

1.71

Neutrophil count

£1076.37

48.03

49.20

32.33

34.50

0.89

1.05

Hemoglobin

£1142.90

45.90

42.55

28.75

28.69

0.09

0.00

Febrile neutropenia

£3579.00

39.06

41.13

21.00

20.49

0.09

0.00

Leukopenia NOS

£1076.37

11.85

13.60

8.04

10.25

0.27

0.00

Lymphopenia

£1956.51

7.14

8.70

6.85

9.05

0.71

0.26

Diarrhea NOS

£817.76

6.38

6.96

1.79

2.22

0.09

0.26

Hypokalemia

£1320.26

5.62

6.80

2.09

3.25

0.00

0.13

Alanine aminotransferase increased

£2421.00

3.19

2.85

3.28

2.22

0.45

0.53

Dermatitis exfoliative NOS

£1057.00

6.38

3.48

0.89

0.68

0.09

0.00

Fatigue

£664.00

2.13

3.64

2.83

1.71

0.09

0.13

Hyperglycemia NOS

£1053.56

1.52

1.90

1.79

1.37

0.27

0.66

Pneumonitis NOS

£892.00

2.74

2.85

1.19

1.71

0.00

0.13

Nausea

£664.00

2.43

4.27

0.74

1.71

0.00

0.00

Hyponatremia

£959.00

4.10

2.85

0.74

0.68

0.00

0.00

Blood bilirubin increased

£959.00

3.34

2.85

0.60

0.68

0.00

0.00

Infection

£3630.12

1.37

1.27

1.94

1.37

0.09

0.00

Hypophosphatasemia

£959.00

2.28

3.64

0.74

0.85

0.00

0.26

Gamma-glutamyltransferase increased

£959.00

1.67

2.85

0.74

1.02

0.09

0.00

Hypocalcemia

£959.00

2.74

2.53

0.30

0.34

0.00

0.00

Radiation mucositis

£664.00

2.28

3.32

0.30

1.02

0.00

0.00

Hypoalbuminemia

£959.00

2.58

2.69

0.45

0.17

0.00

0.00

Syncope

£664.00

0.46

0.00

1.79

1.20

0.00

0.13

Total cost, £

 

4515.62

4624.45

2768.40

2838.50

54.93

87.58

  1. MIDO midostaurin, SOC standard of care, NOS not otherwise specified