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Table 4 Adverse event cost and prevalence

From: Cost-effectiveness analysis for midostaurin versus standard of care in acute myeloid leukemia in the United Kingdom

Adverse event Unit cost (£) Induction Consolidation Monotherapy
MIDO (%) SOC (%) MIDO (%) SOC (%) MIDO (%) SOC (%)
Platelet count decreased £2469.87 50.15 49.99 33.07 34.16 0.18 1.71
Neutrophil count £1076.37 48.03 49.20 32.33 34.50 0.89 1.05
Hemoglobin £1142.90 45.90 42.55 28.75 28.69 0.09 0.00
Febrile neutropenia £3579.00 39.06 41.13 21.00 20.49 0.09 0.00
Leukopenia NOS £1076.37 11.85 13.60 8.04 10.25 0.27 0.00
Lymphopenia £1956.51 7.14 8.70 6.85 9.05 0.71 0.26
Diarrhea NOS £817.76 6.38 6.96 1.79 2.22 0.09 0.26
Hypokalemia £1320.26 5.62 6.80 2.09 3.25 0.00 0.13
Alanine aminotransferase increased £2421.00 3.19 2.85 3.28 2.22 0.45 0.53
Dermatitis exfoliative NOS £1057.00 6.38 3.48 0.89 0.68 0.09 0.00
Fatigue £664.00 2.13 3.64 2.83 1.71 0.09 0.13
Hyperglycemia NOS £1053.56 1.52 1.90 1.79 1.37 0.27 0.66
Pneumonitis NOS £892.00 2.74 2.85 1.19 1.71 0.00 0.13
Nausea £664.00 2.43 4.27 0.74 1.71 0.00 0.00
Hyponatremia £959.00 4.10 2.85 0.74 0.68 0.00 0.00
Blood bilirubin increased £959.00 3.34 2.85 0.60 0.68 0.00 0.00
Infection £3630.12 1.37 1.27 1.94 1.37 0.09 0.00
Hypophosphatasemia £959.00 2.28 3.64 0.74 0.85 0.00 0.26
Gamma-glutamyltransferase increased £959.00 1.67 2.85 0.74 1.02 0.09 0.00
Hypocalcemia £959.00 2.74 2.53 0.30 0.34 0.00 0.00
Radiation mucositis £664.00 2.28 3.32 0.30 1.02 0.00 0.00
Hypoalbuminemia £959.00 2.58 2.69 0.45 0.17 0.00 0.00
Syncope £664.00 0.46 0.00 1.79 1.20 0.00 0.13
Total cost, £   4515.62 4624.45 2768.40 2838.50 54.93 87.58
  1. MIDO midostaurin, SOC standard of care, NOS not otherwise specified