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Table 3 Drug dosages and costs (primary therapy)

From: Cost-effectiveness analysis for midostaurin versus standard of care in acute myeloid leukemia in the United Kingdom

Phase Arm Regimen Dose Mg per cyclea Vial size mg (or tablet) Price per vial/tablet, £ Cost per cycle as per indication, £ Cost with wastage and dose reduction, £
Induction MIDO CYTA 200 mg/m2/day (1–7) 2660 500 £19.50 £103.74 £113.59
DAUNO 60 mg/m2/day (1–3) 342 20 £65.00 £1111.50 £1216.61
MIDO 50 mg (2 × 25) twice per day (8–21) 1400 25 £100.18 £6024.10 £5572.98
Total cost per cycle   £7239.34 £6903.18
SOC CYTA 200 mg/m2/day (1–7) 2660 500 £19.50 £103.74 £112.68
DAUNO 60 mg/m2/day (1–3) 342 20 £65.00 £1111.50 £1216.16
Total cost per cycle   £1215.24 £1328.84
Consolidation MIDO High-dose CYTA 3000 mg/m2/day (1, 3, 5) twice/day 34,200 500 £19.50 £1333.80 £1590.36
MIDO 50 mg (2 × 25) twice/day (8–21) 1400 25 £100.18 £6024.10 £5753.67
Total cost per cycle   £7357.90 £7344.03
SOC High-dose CYTA 3000 mg/m2/day (1, 3, 5) twice/day 34,200 500 £19.50 £1333.80 £1585.32
Total cost per cycle £1333.80 £1585.32
Monotherapy MIDO arm MIDO 50 mg (2 × 25) twice/day (1–28) 2800 25 £100.18 £12,048.19 £11,596.39
Total cost per cycle   £12,048.19 £11,596.39
  1. Cost source: British National Formulary and Novartis
  2. Bold italic indicates total costs, underline indicates values belonging to the MIDO arm in each section
  3. MIDO midostaurin, SOC standard of care, CYTA cytarabine, DAUNO daunomycin
  4. aMg per cycle based on a body surface area of 1.9 m2 (from the RATIFY clinical trial)