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Table 1 Values, ranges, distributions and references for parameters used in the decision tree

From: Cost-effectiveness of diagnostic tests for threatened preterm labor in singleton pregnancy in France

Variables

Value

Rangea

Distribution

References

Incidence of preterm birth (%)

0.097

0.05–0.15

–

[8, 10, 13, 24, 25]

Diagnostic performances

 CL < 25 mm sensitivity

0.78

0.68–0.87

beta

[14]

 CL < 25 mm specificity

0.71

0.67–0.74

beta

[14]

 CL < 15 mm sensitivity

0.6

0.53–0.67

beta

[14]

 CL < 15 mm specificity

0.9

0.89–0.92

beta

[14]

 Qualitative fFN sensitivity

0.75

0.66–0.83

beta

[8, 20]

 Qualitative fFN specificity

0.76

0.73–0.79

beta

[8, 20]

 Quantitative fFN sensitivity

0.59

0.36–0.95

beta

[24]

 Quantitative fFN specificity

0.94

0.91–0.97

beta

[24]

 Cervical IL-6 sensitivity

0.83

0.53–1

beta

[10]

 Cervical IL-6 specificity

0.94

0.89–0.99

beta

[10]

 Combination CL < 18 mm, plasma RANTES, plasma IL-10 sensitivity

0.74

0.63–0.85

beta

[25]

beta

 Combination CL < 18 mm, plasma RANTES, plasma IL-10 specificity

0.86

0.79–0.93

beta

[25]

beta

 CL < 15 mm or CL 16–30 mm and qualitative fFN sensitivity

0.89

0.83–0.95

beta

[13]

 CL < 15 mm or CL 16–30 mm and qualitative fFN specificity

0.7

0.67–0.73

beta

[13]

Probability of perinatal death

 If preterm birth [24–27] GA

0.392

0.35–0.44

beta

[29]

 If preterm birth [28–31] GA

0.078

0.05–0.10

beta

[29]

 If preterm birth [32–34] GA

0.033

0.009–0.057

beta

[29]

 If preterm birth [24–34] GA

0.109

0.09–0.13

–

[29]

Probability of severe neonatal morbidity

[29]

 If preterm birth [24–27] GA

0.303

0.25–0.36

beta

[29]

 If preterm birth [28–31] GA

0.085

0.059–0.11

beta

[29]

 If preterm birth [32–34] GA

0.016

0–0.034

beta

[29]

 If preterm birth [24–34] GA

0.07

0.054–0.086

–

[29]

Probability of subsequent hospitalization

 If preterm birth [24–27] GA

0.13

–

–

PMSI

 If preterm birth [28–31] GA

0.17

–

–

PMSI

 If preterm birth [32–34] GA

0.27

–

–

PMSI

Probability of home follow-up

 If preterm birth [24–27] GA

0.94

–

–

PMSI

 If preterm birth [28–31] GA

0.938

–

–

PMSI

 If preterm birth [32–34] GA

0.916

–

–

PMSI

  1. GA gestational age, CL cervical length, fFN fetal fibronectin, IL interleukin, PMSI Programme de medicalization du système d’information
  2. a Range used for univariate sensitivity analyses