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Table 1 Mortality, re-intervention and HRQoL in the cost-effectiveness decision model

From: Decision uncertainty and value of further research: a case-study in fenestrated endovascular aneurysm repair for complex abdominal aortic aneurysms

  Mean value used in the model Distribution used in the model Source
Early mortality
 Probability of AAA-related mortality, fEVAR, 0–6 m Pr = 0.026 Beta (43,1627) Additional file 1
 Log-odds ratio, fEVAR vs OSR − 0.61 N (Mean − 0.61, SE 1.22) Meta-analysis of 4 studies (adjusted for case-mix)
Late AAA mortality
 Late mortality rate > 6 months–4 years, fEVAR 0.004 Gamma (6, 1/1558) Additional file 1
 Late mortality rate > 4–8 years, fEVAR 0.006 1.5 × 6 months–4 years EVAR-1
 Late mortality rate > 8 years, fEVAR 0.008 2 × 6 months-4 years EVAR-1
 Log Hazard ratio > 6 months-4 years, fEVAR vs OSR 0.38 N (0.38, 0.48) EVAR-1
 Log Hazard ratio > 4–8 years, fEVAR vs OSR 1.13 N (1.13, 0.57) EVAR-1
 Log Hazard ratio > 8 years, fEVAR vs OSR 1.76 N (1.76, 0.63) EVAR-1
Re-interventions 0–6 months
 Probability, fEVAR 0.068 Beta (81, 1117) Additional file 1
 Log odds ratio, fEVAR vs OSR − 0.87 N (− 0.87, 0.24) Meta-analysis of 3 studies (unadjusted for case-mix)
Re-interventions > 6 months
 Re-intervention rate > 6 months-4 years, fEVAR 0.087 Gamma (132, 1/1507) Additional file 1
 Re-intervention rate > 4–8 years, fEVAR   As > 6 months–4 years Assumption
 Re-intervention rate > 8 years, fEVAR   As > 6 months–4 years Assumption
 Log Hazard ratio > 6 months–4 years, fEVAR vs OSR 1.84 N (1.84, 0.35) Additional file 1
 Log Hazard ratio > 4–8 years, fEVAR vs OSR 0.47 N (0.47, 0.34) EVAR-1
 Log Hazard ratio > 8 years, fEVAR vs OSR 0.47 N (0.47, 0.34) EVAR-1
Health related quality of life, EQ-5D index
 After AAA repair, baseline 0.804 N (0.804, 0.021) EVAR-1
 Decrement after OSR 0-6 m − 0.060 N (− 0.060, 0.017) EVAR-1
 Decrement in the 6 months following a re-intervention − 0.060 N (− 0.060, 0.026) EVAR-1
 Decrement in the 6 months before death − 0.149 N (− 0.149, 0.017) EVAR-1
  1. AAA Abdominal aortic aneurysms; OSR Open surgical repair; m months; yr years