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Table 1 Mortality, re-intervention and HRQoL in the cost-effectiveness decision model

From: Decision uncertainty and value of further research: a case-study in fenestrated endovascular aneurysm repair for complex abdominal aortic aneurysms

 

Mean value used in the model

Distribution used in the model

Source

Early mortality

 Probability of AAA-related mortality, fEVAR, 0–6 m

Pr = 0.026

Beta (43,1627)

Additional file 1

 Log-odds ratio, fEVAR vs OSR

− 0.61

N (Mean − 0.61, SE 1.22)

Meta-analysis of 4 studies (adjusted for case-mix)

Late AAA mortality

 Late mortality rate > 6 months–4 years, fEVAR

0.004

Gamma (6, 1/1558)

Additional file 1

 Late mortality rate > 4–8 years, fEVAR

0.006

1.5 × 6 months–4 years

EVAR-1

 Late mortality rate > 8 years, fEVAR

0.008

2 × 6 months-4 years

EVAR-1

 Log Hazard ratio > 6 months-4 years, fEVAR vs OSR

0.38

N (0.38, 0.48)

EVAR-1

 Log Hazard ratio > 4–8 years, fEVAR vs OSR

1.13

N (1.13, 0.57)

EVAR-1

 Log Hazard ratio > 8 years, fEVAR vs OSR

1.76

N (1.76, 0.63)

EVAR-1

Re-interventions 0–6 months

 Probability, fEVAR

0.068

Beta (81, 1117)

Additional file 1

 Log odds ratio, fEVAR vs OSR

− 0.87

N (− 0.87, 0.24)

Meta-analysis of 3 studies (unadjusted for case-mix)

Re-interventions > 6 months

 Re-intervention rate > 6 months-4 years, fEVAR

0.087

Gamma (132, 1/1507)

Additional file 1

 Re-intervention rate > 4–8 years, fEVAR

 

As > 6 months–4 years

Assumption

 Re-intervention rate > 8 years, fEVAR

 

As > 6 months–4 years

Assumption

 Log Hazard ratio > 6 months–4 years, fEVAR vs OSR

1.84

N (1.84, 0.35)

Additional file 1

 Log Hazard ratio > 4–8 years, fEVAR vs OSR

0.47

N (0.47, 0.34)

EVAR-1

 Log Hazard ratio > 8 years, fEVAR vs OSR

0.47

N (0.47, 0.34)

EVAR-1

Health related quality of life, EQ-5D index

 After AAA repair, baseline

0.804

N (0.804, 0.021)

EVAR-1

 Decrement after OSR 0-6 m

− 0.060

N (− 0.060, 0.017)

EVAR-1

 Decrement in the 6 months following a re-intervention

− 0.060

N (− 0.060, 0.026)

EVAR-1

 Decrement in the 6 months before death

− 0.149

N (− 0.149, 0.017)

EVAR-1

  1. AAA Abdominal aortic aneurysms; OSR Open surgical repair; m months; yr years