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Table 1 Parameters incorporated into the Markov model

From: Cost-effectiveness of the recommended medical intervention for the treatment of dysmenorrhea and endometriosis in Japan

Parameters/utility measures

Valuables

Distribution

Source

(a) Probabilistic parameters and utility measures

 Annual incidence of Dysmenorrhea

0.0008–0.007

Age-dependent

National Patient Survey (2011) [9]

 Progress from dysmenorrhea to endometriosis I/II

18.4%

Beta

Taketani et al. (1997) [1]

 Natural healing in dysmenorrhea

80%

Assumption:adjusted by calibration

 Natural healing in endometriosis I/II

40%

Assumption:adjusted by calibration

 Natural healing in endometriosis III/IV

80%

Assumption:adjusted by calibration

 Recurrence

22.2%

Beta

Taketani et al. (1997) [1]

 Visit proportion for dysmenorrhea

0.03–0.5

Age-dependent

Calculation from Taketani et al. (1997) [1] and National Patient Survey (2011) [9]

 Visit proportion for endometriosis

0.0124–0.0307

Age-dependent

 Surgery for endometriosis

6.0%

Normal

Tanaka et al. (2013) [6]

 Proportion of OTC use for self-medication

87.1%

Normal

Tsutsumi et al. (2002) [28]

 Annual other-cause death

Age-dependent

Life-time table (2013) [10]

 Odds ratio for risk reduction in the development of endometriosis I/II

0.40

LogNor

Vessey et al. (1993) [11]

 Odds ratio for risk reduction in the progression to endometriosis III/IV

0.10

LogNor

Tutunaru et al. (2006) [12]/Duffy et al. (2014) [13]

 Utility for dysmenorrhea

0.637

LogNor

Assumed that utility for dysmenorrhea is the same as that for endometriosis I/II

 Utility for endometriosis I/II

0.637

LogNor

Institution-based QOL survey using visual analogue scales

 Utility for endometriosis III/IV

0.549

LogNor

 Utility for cured

1.000

Assumption

Costs (JPY)/utilizations

Valuables

Distribution

Source

(b) Cost parameters and resource utilizations

 Annual frequency of visits for dysmenorrhea

4

Assumption

 Visit cost for dysmenorrhea

7529

LogNor

Resource utilization survey (2011) [16]

 Annual frequency of visits for endometriosis

4

Assumption

 Visit cost for endometriosis

11,291

LogNor

Resource utilization survey (2011) [16]

 Annual inpatient cost (excl. surgery cost)

207,661

LogNor

 Cost of surgery (mild)

288,080

LogNor

National insurance price list established by the surgeons’ group (2014) [29]

 Cost of surgery (complex)

456,667

LogNor

 Proportion of complex casesa

45.2%

LogNor

Nagata et al. (1982) [30]

 Annual OTC cost used (self-care)

19,243

LogNor

Recalculation of raw data from Tanaka et al. (2013) [6]

 Annual self-medication cost (self-care)

13,715

LogNor

 Productivity loss (half year, self-care)

184,625

LogNor

 Productivity loss (half year, guideline-based intervention)

39,546

LogNor

  1. OTC over the counter, US$ 1 = approximately 120 JPY
  2. a Complex cases were defined as cases diagnosed as either severe or extensive using the American Fertility Society Classification of Endometriosis (AFS Classification)