Table 2 The expected values and 95% CrI of model outcomes over 10 years

Cost (95% CrI)

$38,432 ($32,075–$48,657)

$41,535 ($35,034–$54,699)

$217,847 ($214,477–$224,863)

QALYs (95% CrI)

6.79 (6.63–6.96)

6.88 (6.69–7.07)

7.17 (6.99–7.37)

Number of weeks with non-severe exacerbations (95% CrI)

20.04 (15.90–24.64)

14.53 (11.07–18.87)

9.92 (7.34–12.91)

Number of weeks with severe exacerbations without hospitalization (95% CrI)

11.39 (7.21–16.16)

8.22 (5.03–11.97)

7.15 (4.14–10.94)

Number of hospitalizations (95% CrI)

1.10 (0.45–2.19)

1.05 (0.31–2.46)

0.54 (0.14–1.48)

ICER

 Tiotropium versus standard therapy

Reference

$34,478/QALY

–

 Omalizumab versus tiotropium

–

Reference

$593,643/QALY

 Omalizumab versus standard therapy

Reference

–

$463,605/QALY