Table 1 Model Parameters

Baseline age

40

–

Background mortality rate [30]

US life tables

–

Monthly chance of death from hospitalization [31]

0.0248

Beta(1.099, 43.224)

Direct cost (2013-$US) [2, 3]

Standard therapy costs (per person week)^a

 Controlled

$46

–

 Partially controlled

$47

–

 Uncontrolled

$53

–

Treatment costs (per person week) [2, 3, 10, 21, 22]

 Tiotropium

$13

–

 Omalizumab

$437

–

Cost of exacerbations (per person week) [2, 3]

 Non-severe exacerbation

$130

Gamma(100, 0.77)

 Severe exacerbation without hospitalization

$594

Gamma(98.01, 0.17)

 Hospitalization

$9900

Gamma(100.08, 0.01)

Indirect cost (per person week) (used only for sensitivity analysis) [1, 4, 22]

 Controlled

$165

–

 Partially controlled

$185

–

 Uncontrolled

$312

–

 Exacerbation (Including not severe exacerbation, severe exacerbation and hospitalization)

$856

–

Health state utility values [10, 21, 22]

 Controlled

0.937

Beta(982.3883, 66.0517)

 Partially controlled

0.907

Beta(378.5135, 38.8112)

 Uncontrolled

0.728

Beta(1212.6010, 453.0598)

 Non-severe exacerbation

0.649

Beta(1243.7040, 672.6349)

 Severe exacerbation without hospitalization

0.570

Beta(1175.3160, 886.6418)

 Hospitalization

0.330

Beta(613.7850, 1246.1690)