Incorporating economies of scale in the cost estimation in economic evaluation of PCV and HPV vaccination programmes in the Philippines: a game changer?

Table 13 Incremental cost-effectiveness ratio of HPV vaccination alone compared to cervical cancer screening alone: Incremental cost-effectiveness ratio of HPV vaccination without taking into account economies of scale and cervical cancer screening with applying economies of scale

ICER (USD/QALY)	Percent coverage of screening (with EoS approach)
Percent coverage of HPV vaccine (not taking into account EoS approach)	% coverage	10	20	30	40	50	60	70	80	90	100
	10	− 310^a	− 11450^a	− 2230^a	− 2620^a	− 2760^a	− 1960^a	− 2150^a	− 1640^a	− 1790^a	− 1910^a
	20	− 220^a	1730^b	4100^c	− 15970^a	− 6660^a	− 3550^a	− 3410^a	− 2380^a	− 2480^a	− 2540^a
	30	− 200^a	700^b	860^b	3350^c	12580^c	− 31670^a	− 9250^a	− 4670^a	− 4180^a	− 3910^a
	40	− 200^a	390^b	410^b	1410^b	3030^c	4100^c	11030^c	119470^c	− 15490^a	− 9070^a
	50	− 190^a	240^b	230^b	840^b	1660^b	1820^b	3280^c	3990^c	8180^c	22910^c
	60	− 190^a	150^b	140^b	570^b	1110^b	1130^b	1870^b	1940^b	3100^c	4840^c
	70	− 190^a	100^b	80^b	420^b	810^b	790^b	1270^b	1240^b	1860^b	2630^b
	80	− 190^a	60^b	40^b	310^b	620^b	590^b	940^b	890^b	1300^b	1780^b
	90	− 190^a	30^b	10^b	240^b	500^b	460^b	740^b	680^b	980^b	1320^b
	100	− 190^a	0^b	− 20^b	190^b	400^b	370^b	600^b	530^b	780^b	1030^b

ICER incremental cost-effectiveness ratio; EoS economies of scale; HPV human papillomavirus vaccine
^aCost-effective
^bCost-ineffective
^cHighly cost-ineffective

ISSN: 1478-7547