Table 3 One way sensitivity analysis
Variable | Value used in the Markov model | Value at which IORT no longer has the highest NMB |
|---|---|---|
Utility QoL with no recurrence of breast cancer based on a scale of 0–1; with “1” being in perfect health and “0” resulting in death (Fig. 4) | 0.92 [19] | 0 |
Probability of recurrent cancer and death IORT (includes local and other cancer and death) > 10 years out (Fig. 5) | 23% [2] | > 30% |
Probability of recurrent cancer and death EBRT (includes local and other cancer and death) > 10 years out (Fig. 6) | 25.4% [2] | < 19% |
Life expectancy metastatic recurrent cancer (Fig. 7) | > 51 years | |
Probability IORT complication long term (> 10 years) due to radiation exposure. Includes ischemic heart disease and cancers (Fig. 8) | 0.31% [7] | > 24% |