Cost-effectiveness of human papillomavirus vaccination in Germany

Table 8 Cost-effectiveness of vaccinating boys and girls compared with vaccinating girls alone

Vaccination strategy		Comparator (coverage in 12-year-old girls, no vaccination of boys), %	Incremental cases prevented (undiscounted)		ICER (€/QALY)
Vaccination strategy			Incremental cases prevented (undiscounted)		Bivalent vaccination				Quadrivalent vaccination
Coverage in 12-year-old girls, %	Coverage in 12-year-old boys, %		Cervical cancer	Cervical cancer death	Health care payer perspective		Societal perspective		Health care payer perspective		Societal perspective
Coverage in 12-year-old girls, %	Coverage in 12-year-old boys, %		Cervical cancer	Cervical cancer death	2 doses	3 doses	2 doses	3 doses	2 doses	3 doses	2 doses	3 doses
50 (base case)	0 (base case)	0 (base case)	99,914	23,703	19,450	34,249	13,248	28,047	3645	14,711	Cost-saving	8984
50	20	50	16,899	4396	67,129	105,794	61,077	99,742	58,549	94,186	52,648	88,284
50	50	50	32,923	8628	83,602	130,449	77,607	124,453	73,973	117,240	68,118	111,386
50	80	50	37,335	9906	110,977	171,424	105,091	165,538	98,369	153,849	92,625	148,105
20	0	0	46,844	10,815	15,659	28,568	9410	22,318	Cost-saving	3387	Cost-saving	Cost-saving
20	20	20	28,308	7110	34,669	57,024	28,663	51,019	19,892	37,985	14,223	32,316
20	50	20	68,041	17,040	37,066	60,682	30,959	54,574	26,478	46,965	20,617	41,104
20	80	20	87,611	22,065	46,525	74,844	40,440	68,758	36,033	61,027	30,164	55,158
80	0	0	133,226	32,295	25,028	42,605	18,873	36,450	10,562	24,412	4798	18,648
80	20	80	2157	658	313,627	475,013	308,346	469,732	269,103	410,286	263,974	405,157
80	50	80	4365	1332	364,237	550,917	358,953	545,633	311,264	473,605	306,138	468,478
80	80	80	5934	1809	413,018	624,085	407,724	618,790	352,012	534,785	346,880	529,653

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