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Table 8 Cost-effectiveness of vaccinating boys and girls compared with vaccinating girls alone

From: Cost-effectiveness of human papillomavirus vaccination in Germany

Vaccination strategy Comparator (coverage in 12-year-old girls, no vaccination of boys), % Incremental cases prevented (undiscounted) ICER (€/QALY)
Bivalent vaccination Quadrivalent vaccination
Coverage in 12-year-old girls, % Coverage in 12-year-old boys, % Cervical cancer Cervical cancer death Health care payer perspective Societal perspective Health care payer perspective Societal perspective
2 doses 3 doses 2 doses 3 doses 2 doses 3 doses 2 doses 3 doses
50 (base case) 0 (base case) 0 (base case) 99,914 23,703 19,450 34,249 13,248 28,047 3645 14,711 Cost-saving 8984
50 20 50 16,899 4396 67,129 105,794 61,077 99,742 58,549 94,186 52,648 88,284
50 50 50 32,923 8628 83,602 130,449 77,607 124,453 73,973 117,240 68,118 111,386
50 80 50 37,335 9906 110,977 171,424 105,091 165,538 98,369 153,849 92,625 148,105
20 0 0 46,844 10,815 15,659 28,568 9410 22,318 Cost-saving 3387 Cost-saving Cost-saving
20 20 20 28,308 7110 34,669 57,024 28,663 51,019 19,892 37,985 14,223 32,316
20 50 20 68,041 17,040 37,066 60,682 30,959 54,574 26,478 46,965 20,617 41,104
20 80 20 87,611 22,065 46,525 74,844 40,440 68,758 36,033 61,027 30,164 55,158
80 0 0 133,226 32,295 25,028 42,605 18,873 36,450 10,562 24,412 4798 18,648
80 20 80 2157 658 313,627 475,013 308,346 469,732 269,103 410,286 263,974 405,157
80 50 80 4365 1332 364,237 550,917 358,953 545,633 311,264 473,605 306,138 468,478
80 80 80 5934 1809 413,018 624,085 407,724 618,790 352,012 534,785 346,880 529,653
  1. ICER incremental cost-effectiveness ratio, QALY quality-adjusted life year