The value of using a brain laser interstitial thermal therapy (LITT) system in patients presenting with high grade gliomas where maximal safe resection may not be feasible

Table 1 Studies examining the use of LITT with high grade gliomas in areas of eloquence

Study	Number patients identified with tumors in areas of eloquence	Tumor type	Length of stay	Extent resection	KPS (pre/post)	Major complications (%)^a
Sakai [42]	3	Denovo glioma	N/A	100 %	Two patients had a 90 and 100 KPS pre-surgery; other not mentioned	0
Reimer [43]	4	Recurrent glioma	Shorter with LITT vs. craniotomy	N/A	N/A	0
Schwarzmaier [40]	16	rGBM	Shorter with LITT vs. craniotomy	N/A	N/A	0
Carpentier [44]	4	rGBM	Patients discharged the next day	100 %	Unchanged pre and post-surgery	0
Jethwa [45]	3	GBM	Median 1 day	100 %	N/A	0
Sloan [46]	8	rGBM	3.75 ± 1.83 days (mean ± SD)	78 ± 12 %	Pre-surgery 85; post 83	0
Schroeder [47]	2	Anaplastic astrocytoma	N/A	92.8 % (mean) [range 77.7–100 %]	Pre-surgery 80	0
Mohammadi [24]	35	rGBM = 19 Glioma/GBM = 16	Median 3 days (range 1–29 days)	98.2 % (median)	Pre-surgery 80	6
Totals	75					(2/75 = 2.7)

KPS Karnofsky performance scale, rGBM recurrent glioblastoma multiforme, GBM glioblastoma multiforme
^aMajor complications = Neurocognitive complications extending >3 months post surgery

ISSN: 1478-7547