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Table 1 Studies examining the use of LITT with high grade gliomas in areas of eloquence

From: The value of using a brain laser interstitial thermal therapy (LITT) system in patients presenting with high grade gliomas where maximal safe resection may not be feasible

Study Number patients identified with tumors in areas of eloquence Tumor type Length of stay Extent resection KPS (pre/post) Major complications (%)a
Sakai [42] 3 Denovo glioma N/A 100 % Two patients had a 90 and 100 KPS pre-surgery; other not mentioned 0
Reimer [43] 4 Recurrent glioma Shorter with LITT vs. craniotomy N/A N/A 0
Schwarzmaier [40] 16 rGBM Shorter with LITT vs. craniotomy N/A N/A 0
Carpentier [44] 4 rGBM Patients discharged the next day 100 % Unchanged pre and post-surgery 0
Jethwa [45] 3 GBM Median 1 day 100 % N/A 0
Sloan [46] 8 rGBM 3.75 ± 1.83 days (mean ± SD) 78 ± 12 % Pre-surgery 85; post 83 0
Schroeder [47] 2 Anaplastic astrocytoma N/A 92.8 % (mean) [range 77.7–100 %] Pre-surgery 80 0
Mohammadi [24] 35 rGBM = 19
Glioma/GBM = 16
Median 3 days (range 1–29 days) 98.2 % (median) Pre-surgery 80 6
Totals 75      (2/75 = 2.7)
  1. KPS Karnofsky performance scale, rGBM recurrent glioblastoma multiforme, GBM glioblastoma multiforme
  2. aMajor complications = Neurocognitive complications extending >3 months post surgery