Table 2 Model baseline population parameters
Parameter | Values and % of patients | Standard errora | Distributions used in the PSA |
|---|---|---|---|
Gender | |||
Female (%) | 32.0 % | 1.15 % | Beta |
Mean age (years) | 63.3 | 0.1 | Normal |
BMI | |||
Low (%) | 10.4 % | 0.84 % | Beta |
Medium (%) | 65.1 % | – | – |
High (%) | 24.5 % | 1.02 % | Beta |
Any CVD comorbidity (%) | 43.5 % | 1.13 % | Beta |
Without comorbidity (%) | 56.5 % | – | – |
Any other comorbidity (%) | 77.3 % | 1.07 % | Beta |
History of exacerbation, 1 or more (%) | 46.2 % | 1.21 % | Beta |
mMRC score ≥2 (%) | 100.0 % | – | |
Current smokers (%) | 49.0 % | 1.16 % | Beta |
Height (cm) | 169.0 | 0.1 | Normal |
Fibrinogen (µg/mL) | 458.8 | 102.4 | Gamma |
Number of exacerbations in prior year | 0.50 | 0.01 | Gamma |
Proportion of prior exacerbations that are severe | 20.0 | Gamma | |
Starting SGRQ score | 49.1 | 0.5 | Normal |
Starting FEV1 %p (%) | 47.7 % | 0.2 % | Beta |
6-min walk distance (m) | 378.3 | 2.9 | Normal |