Table 3 Resistance to therapy for chronic Hepatitis B treatment [11–16]
Years | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Resistance | |||||||||||||||||||
 TDF | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
 ETV | 0.2 | 0.3 | 0.7 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
 3TC | 6.7 | 11.3 | 21.0 | 11.3 | 6.4 | 3.2 | 1.6 | 0.8 | 0.4 | 0.2 | 0.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
 LtD/Hbe− | 1.1 | 2.2 | 4.1 | 2.2 | 1.2 | 0.6 | 0.3 | 0.2 | 0.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
 LtD/Hbe+ | 5.0 | 6.3 | 11.6 | 6.3 | 3.5 | 1.8 | 0.9 | 0.4 | 0.2 | 0.1 | 0.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
Cumulative resistance | |||||||||||||||||||
 TDF | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
 ETV | 0.2 | 0.5 | 1.2 | 1.2 | 1.2 | 1.2 | 1.2 | 1.2 | 1.2 | 1.2 | 1.2 | 1.2 | 1.2 | 1.2 | 1.2 | 1.2 | 1.2 | 1.2 | 1.2 |
 3TC | 6.7 | 18.0 | 39.0 | 50.3 | 56.7 | 59.9 | 61.5 | 62.3 | 62.7 | 62.9 | 63.0 | 63.1 | 63.1 | 63.1 | 63.1 | 63.1 | 63.1 | 63.1 | 63.1 |
 LtD/Hbe− | 1.1 | 3.3 | 7.4 | 9.6 | 10.8 | 11.4 | 11.8 | 11.9 | 12.0 | 12.0 | 12.1 | 12.1 | 12.1 | 12.1 | 12.1 | 12.1 | 12.1 | 12.1 | 12.1 |
 LtD/Hbe + | 5.0 | 11.3 | 22.9 | 29.1 | 32.7 | 34.4 | 35.3 | 35.8 | 36.0 | 36.1 | 36.1 | 36.2 | 36.2 | 36.2 | 36.2 | 36.2 | 36.2 | 36.2 | 36.2 |