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Table 1 Probabilities of transition of the model. Absolute effectiveness: American College of Rheumatology (ACR) response rates (%) at 3 and 6 months estimated from published clinical studies (references cited are the clinical studies upon which the estimates were based)

From: Cost-utility analysis of certolizumab pegol versus alternative tumour necrosis factor inhibitors available for the treatment of moderate-to-severe active rheumatoid arthritis in Spain

 

3 months

6 months

ACR20

ACR50

ACR70

ACR20

ACR50

ACR70

Combination therapies

MTX [9, 17, 3643, 6163]

 

21.5

7.2

2.0

24.2

9.7

3.7

CZP + MTX [16, 17, 36]

 

71.1

35.9

21.6

77.2

49.2

28.2

ADA + MTX [9, 37, 41]

 

70.8

na

na

61.0

41.8

19.7

ETA + MTX [38, 39]

 

66.4

61.1

23.7

68.5

66.4

30.7

IFX + MTX [40, 42, 43]

 

58.6

27.0

19.6

48.2

26.1

11.3

Monotherapies

Placebo [14, 4447]

 

14.0

3.2

1.1

13.1

5.7

1.0

CZP [14]

 

53.3

45.1

11.6

55.9

31.4

12.3

ADA [44, 45, 47]

 

55.3

25.7

16.4

39.0

18.8

8.5

ETA [46]

 

46.2

21.4

5.1

62.0

42.3

12.9

  1. ADA adalimumab, CZP certolizumab pegol, ETA etanercept, IFX infliximab, MTX methotrexate, na not available