Table 1 Key input parameters for cost-effectiveness base case and sensitivity analyses

Cost (2012 US$)

Cost per fully immunised child for rota vaccine (RV1) at 93% coverage (cRotaVac)**

16.99

±25%

Gamma

Table 2

Cost per OPD visit for diarrhoea treatment (cModD)

3.84

±25%

Gamma

Table 3

Cost of in-patient diarrhoea treatment per bed day (cSevD)

8.90

±25%

Gamma

Table 4

Cost discounting rate (cDR)

0.03

0.00 – 0.06

N/A

[15]

Disability weights

Disability weight moderate Diarrhoea (uModD)

0.202

0.133 - 0.299

Beta

[32]

Disability weight severe Diarrhoea (USevD)

0.281

0.184 - 0.399

Beta

[32]

Outcome discounting rate (oDR)

0.030

0.000 – 0.060

N/A

[15]

Effectiveness (Relative Risk ratio)

Effectiveness of RotaVaccine on all cause diarrhoea (effRotaVac)

0.698

0.570 - 0.850

Log-normal

[23]

Effectiveness of IMCI on moderate diarrhoea (effImci_OPD)

0.590

0.430 - 0.680

Log-normal

[24]

Effectiveness of IMCI on severe diarrhoea (effImci_IPD)

0.570

0.420 - 0.660

Log-normal

[25]

Transition Probabilities (weekly)

Probability of progressing from well to moderate diarrhoea (tpModD)

0.116

0.072 - 0.167

Beta

[3]

Probability of progressing from moderate to severe diarrhoea (tpSevD)

0.048

0.035 - 0.056

Beta

[27]

Probability of recurrent moderate diarrhoea (tpRecModD)

0.005

0.004 – 0.006

Beta

[28]

Probability of recurrent severe diarrhoea (tpRecSevD)

0.0038

0.003 – 0.0045

Beta

[28]

Mortality

Probability of dying from diarrhoea (Case fatality rate (CFR) <5 yrs (%))

0.019

0.0119 -0.0265

Normal

[27]

(PDeath_NoInt)

General

Average number of bed days spent in hospital

4

2 - 6

N/A

Primary data

Diarrhoea treatment coverage rates

41%

44%-68%

N/A

[30]

Vaccine coverage rates ( reference to DPT-HB-Hib coverage)

93%

85% – 95%

N/A

[30]

Healthy life expectancy at birth

52

49,4 - 53,1

N/A

[32]