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Table 3 Utilities and utility decrements used in modelling studies

From: Health economic evaluations comparing insulin glargine with NPH insulin in patients with type 1 diabetes: a systematic review

Author/Study Cameron et al.
[21]
Grima et al.
[22]
McEwan et al.
[23]
Brändle et al.
[25]
Warren et al.
[24]
Warren et al.
[20]
Health state Utility decrement a Utility values f Utility decrement a Utility decrement a Utility decrement a
Data except for hypoglycaemia confidential to NICE
Ischaemic heart disease, first & subsequent years - - -0.09 -0.09 n/a n/a
Myocardial infarction, year of event -0.0409222 0.760 -0.066 -0.055 n/a n/a
Myocardial infarction, subsequent years -0.012 0.800 -0.066 -0.055 n/a n/a
Angina, year of event -0.0411989 - - - n/a n/a
Angina, subsequent years -0.024 - - - n/a n/a
Congestive heart failure, year of event -0.0546 0.693 -0.108 -0.108 n/a n/a
Congestive heart failure, subsequent years -0.018 0.693 -0.108 -0.108 n/a n/a
Stroke, year of event -0.0523513 0.720 -0.114 -0.164 n/a n/a
Stroke, subsequent years -0.040 0.800 -0.114 -0.164 n/a n/a
Peripheral vascular disease -0.021 - - - n/a n/a
Microalbuminuria -0.012 - - - n/a n/a
Proteinuria -0.017 - - - n/a n/a
ESRD, first and subsequent years - 0.644 -0.263 -0.263 n/a n/a
Dialysis, first & subsequent years -0.16 - -0.305 -0.305 n/a n/a
Funct. kidney transplant, first & subsequent years -0.03 - -0.075 -0.075 n/a n/a
Diabetic retinopathy -0.0155836 0.750 - - n/a n/a
Blindness and low vision -0.0497859 - - - n/a n/a
Pre-blind, first & subsequent years - - -0.029 -0.029 n/a n/a
Blind, first & subsequent years - - -0.074 -0.074 n/a n/a
Cataract -0.0170832 - - - n/a n/a
Macular edema -0.0170832 - - - n/a n/a
Neuropathy -0.0243702 - - - n/a n/a
Active uninfected diabetic ulcer -0.09 - - - n/a n/a
Active infected diabetic ulcer -0.14 - - - n/a n/a
Amputation -0.266 0.678 -0.28 -0.28 n/a n/a
Amputation, subsequent years - 0.800 - - n/a n/a
Fear of any hypoglycaemic episode - - - - -0.0019d -0.0052d
Severe hypoglycaemic episode -0.5485b - -0.047d -0.047d -0.15e -0.15e
Mild/moderate hypoglycaemic episode -0.167c - - - - -
Symptomatic hypoglycaemic episode - - -0.0142d -0.0142d - -
Nocturnal hypoglycaemic episode - - -0.0084d -0.0084d - -
  1. Legend: ESRD = endstage renal disease
  2. aapplied for 1-year (but not for subsequent years, hypoglycemic episodes and ulcers)
  3. bdecrement for 24 hours
  4. cdecrement for 15 minutes
  5. dunclear duration
  6. edecrement for 4 days
  7. fnot additive, lowest utility in respective year is used